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Journal Articles

ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses

Irem Kaymak, McLane J. Watson, Brandon M. Oswald, Shixin Ma, Benjamin K. Johnson, Lisa M. DeCamp, Batsirai M. Mabvakure, Katarzyna M. Luda, Eric H. Ma, Kin Lau, Zhen Fu, Brejnev Muhire, Susan M. Kitchen-Goosen, Alexandra Vander Ark, Michael S. Dahabieh, Bozena Samborska, Matthew Vos, Hui Shen, Zi Peng Fan, Thomas P. Roddy, Gillian A. Kingsbury, Cristovão M. Sousa, Connie M. Krawczyk, Kelsey S. Williams, Ryan D. Sheldon, Susan M. Kaech, Dominic G. Roy, Russell G. Jones
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20231820.
https://doi.org/10.1084/jem.20231820
Published: 16 August 2024
View article titled, ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses
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Includes: Supplementary data
Journal Articles

The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes

In Special Collection:
Mechanisms and Models of Cancer 2024
Mark Esposito, John K. Amory, Yibin Kang
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (9): e20240519.
https://doi.org/10.1084/jem.20240519
Published: 12 August 2024
View article titled, The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
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Journal Articles

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

In Special Collection:
Immunometabolism 2024 , Mechanisms and Models of Cancer 2024
Yun Xue, Yuting Chen, Sijia Sun, Xinyuan Tong, Yujia Chen, Shijie Tang, Xue Wang, Simin Bi, Yuqin Qiu, Qiqi Zhao, Zhen Qin, Qin Xu, Yingjie Ai, Leilei Chen, Beizhen Zhang, Zhijie Liu, Minbiao Ji, Meidong Lang, Luonan Chen, Guoliang Xu, Liang Hu, Dan Ye, Hongbin Ji
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20240111.
https://doi.org/10.1084/jem.20240111
Published: 28 May 2024
View article titled, TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition
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Includes: Supplementary data
Journal Articles

Stress relief of chemo illness

Adam J. Rose, Sarah H. Lockie
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20240545.
https://doi.org/10.1084/jem.20240545
Published: 06 May 2024
View article titled, Stress relief of chemo illness
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Journal Articles

Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy

Yuexiao Tang, Tao Yao, Xin Tian, Xintong Xia, Xingxiao Huang, Zhewen Qin, Zhong Shen, Lin Zhao, Yaping Zhao, Bowen Diao, Yan Ping, Xiaoxiao Zheng, Yonghao Xu, Hui Chen, Tao Qian, Tao Ma, Ben Zhou, Suowen Xu, Qimin Zhou, Yong Liu, Mengle Shao, Wei Chen, Bo Shan, Ying Wu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (7): e20231395.
https://doi.org/10.1084/jem.20231395
Published: 02 May 2024
View article titled, Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy
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Includes: Supplementary data
Journal Articles

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation

In Special Collection:
Barrier Immunity , Autoimmunity 2024 , Immunometabolism 2024
Emeline Joulia, Michaël F. Michieletto, Arantxa Agesta, Cindy Peillex, Virginie Girault, Anne-Louise Le Dorze, Romain Peroceschi, Florence Bucciarelli, Marion Szelechowski, Adeline Chaubet, Nawad Hakim, Rémi Marrocco, Emeline Lhuillier, Manuel Lebeurrier, Rafael J. Argüello, Abdelhadi Saoudi, Hicham El Costa, Veronique Adoue, Thierry Walzer, Jean-Emmanuel Sarry, Anne S. Dejean
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20230449.
https://doi.org/10.1084/jem.20230449
Published: 08 January 2024
View article titled, Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4<sup>+</sup> T cells during inflammation
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Includes: Supplementary data
Journal Articles

Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH

In Special Collection:
Immunometabolism 2024
Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, Yasushi Honda, Mitsuyo Maeda, Yasuyuki Saito, Yoji Murata, Takashi Matozaki, Atsushi Nakajima, Yosky Kataoka, Tomoo Ogi, Yoshihiro Ogawa, Takayoshi Suganami
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (11): e20220681.
https://doi.org/10.1084/jem.20220681
Published: 19 September 2023
View article titled, Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH
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Includes: Supplementary data
Journal Articles

Distinct inflammatory Th17 subsets emerge in autoimmunity and infection

In Special Collection:
Autoimmunity: From Novel Mechanisms to Treatments
Ronald J. Bouch, Jing Zhang, Brandi C. Miller, Caroline J. Robbins, Timothy H. Mosher, Wencheng Li, Sergey A. Krupenko, Ravinder Nagpal, Jun Zhao, Richard S. Bloomfeld, Yong Lu, Mikhail A. Nikiforov, Qianqian Song, Zhiheng He
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (10): e20221911.
https://doi.org/10.1084/jem.20221911
Published: 27 June 2023
View article titled, Distinct inflammatory Th17 subsets emerge in autoimmunity and infection
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Includes: Supplementary data
Journal Articles

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

In Special Collection:
Cytokines Collection 2023 , Immunometabolism 2024
Bastiaan Maes, Farzaneh Fayazpour, Leen Catrysse, Guillaume Lornet, Evelien Van De Velde, Caroline De Wolf, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Kim Deswarte, Benedicte Descamps, Christian Vanhove, Bart Van der Schueren, Roman Vangoitsenhoven, Hamida Hammad, Sophie Janssens, Bart N. Lambrecht
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (9): e20210788.
https://doi.org/10.1084/jem.20210788
Published: 22 June 2023
View article titled, STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity
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Includes: Supplementary data
Journal Articles

Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling

Jingya Xu, Xiaofei Li, Wei Chen, Ziyin Zhang, Yanping Zhou, Yahui Gou, Cheng-an Lv, Lu Jin, Xinyuan Qiu, Shengshan Ma, Qing-Qian Wu, Tongyu Liu, Lin Mi, Zhuoying Yang, Ting Yu, Xiaowen Pan, Yu Feng, Pengfei Shan, Zhuo-Xian Meng
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (9): e20221123.
https://doi.org/10.1084/jem.20221123
Published: 07 June 2023
View article titled, Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling
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Includes: Supplementary data
Journal Articles

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

In Special Collection:
Hematology and Stem Cells 2023
Yoon-A Kang, Hyojung Paik, Si Yi Zhang, Jonathan J. Chen, Oakley C. Olson, Carl A. Mitchell, Amelie Collins, James W. Swann, Matthew R. Warr, Rong Fan, Emmanuelle Passegué
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (8): e20230088.
https://doi.org/10.1084/jem.20230088
Published: 26 April 2023
View article titled, Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
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Includes: Supplementary data
Journal Articles

Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

In Special Collection:
Tumor Microenvironment and Metastasis 2023 , Metabolism Signaling
Michael A. Gonzalez, Daniel R. Lu, Maryam Yousefi, Ashley Kroll, Chen Hao Lo, Carlos G. Briseño, J. E. Vivienne Watson, Sergey Novitskiy, Vanessa Arias, Hong Zhou, Andres Plata Stapper, Min K. Tsai, Emily L. Ashkin, Christopher W. Murray, Chi-Ming Li, Monte M. Winslow, Kristin V. Tarbell
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (6): e20221472.
https://doi.org/10.1084/jem.20221472
Published: 30 March 2023
View article titled, Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages
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Includes: Supplementary data
Journal Articles

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

In Special Collection:
Fibrosis Collection 2023 , Metabolism Signaling
Giorgia Benegiamo, Giacomo V.G. von Alvensleben, Sandra Rodríguez-López, Ludger J.E. Goeminne, Alexis M. Bachmann, Jean-David Morel, Ellen Broeckx, Jing Ying Ma, Vinicius Carreira, Sameh A. Youssef, Nabil Azhar, Dermot F. Reilly, Katharine D’Aquino, Shannon Mullican, Maroun Bou-Sleiman, Johan Auwerx
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (4): e20221738.
https://doi.org/10.1084/jem.20221738
Published: 14 February 2023
View article titled, The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression
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Includes: Supplementary data
Journal Articles

MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Tumor Microenvironment and Metastasis 2023 , Metabolism Signaling
Mark R. Silvis, Dilru Silva, Riley Rohweder, Sophia Schuman, Swapna Gudipaty, Amanda Truong, Jeffrey Yap, Kajsa Affolter, Martin McMahon, Conan Kinsey
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (3): e20221524.
https://doi.org/10.1084/jem.20221524
Published: 31 January 2023
View article titled, MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition
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Includes: Supplementary data
Journal Articles

Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses

In Special Collection:
Immunology Update Winter 2023 , Innate Lymphoid Cells & Unconventional T Cells , Metabolism Signaling , 2023: The Year in Experimental Medicine
Suzanne H. Hodge, Maria Z. Krauss, Irem Kaymak, James I. King, Andrew J.M. Howden, Gordana Panic, Richard K. Grencis, Jonathan R. Swann, Linda V. Sinclair, Matthew R. Hepworth
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (3): e20221073.
https://doi.org/10.1084/jem.20221073
Published: 26 December 2022
View article titled, Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses
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Journal Articles

Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition

In Special Collection:
JEM Cancer Collection 2023 , Metabolism Signaling
Qiaoyun Chu, Jing An, Ping Liu, Yihan Song, Xuewei Zhai, Ronghui Yang, Jing Niu, Chuanzhen Yang, Binghui Li
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (3): e20221316.
https://doi.org/10.1084/jem.20221316
Published: 15 December 2022
View article titled, Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition
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Includes: Supplementary data
Journal Articles

Metabolic features of innate lymphoid cells

In Special Collection:
Innate Lymphoid Cells & Unconventional T Cells , JEM Immunology Collection 2023 , Metabolism Signaling
Huiyang Yu, Nicolas Jacquelot, Gabrielle T. Belz
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (11): e20221140.
https://doi.org/10.1084/jem.20221140
Published: 27 October 2022
View article titled, Metabolic features of innate lymphoid cells
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Journal Articles

Eating away T cell responses in lung cancer

Roberto Ferrara, Luca Roz
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (12): e20221449.
https://doi.org/10.1084/jem.20221449
Published: 10 October 2022
View article titled, Eating away T cell responses in lung cancer
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Journal Articles

Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice

In Special Collection:
Metabolism Signaling
Catalina Cosovanu, Philipp Resch, Stefan Jordan, Andrea Lehmann, Markus Ralser, Vadim Farztdinov, Joachim Spranger, Michael Mülleder, Sebastian Brachs, Christian Neumann
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (12): e20220233.
https://doi.org/10.1084/jem.20220233
Published: 19 September 2022
View article titled, Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice
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Includes: Supplementary data
Journal Articles

Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

In Special Collection:
Hematology 2022
Chong Yang, Rui Yokomori, Lee Hui Chua, Shi Hao Tan, Darren Qiancheng Tan, Kenichi Miharada, Takaomi Sanda, Toshio Suda
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (12): e20220685.
https://doi.org/10.1084/jem.20220685
Published: 16 September 2022
View article titled, Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47
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