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Journal Articles

Cigarette smoke components modulate the MR1–MAIT axis

Wael Awad, Jemma R. Mayall, Weijun Xu, Matt D. Johansen, Timothy Patton, Xin Yi Lim, Izabela Galvao, Lauren J. Howson, Alexandra C. Brown, Tatt Jhong Haw, Chantal Donovan, Shatarupa Das, Gesa J. Albers, Tsung-Yu Pai, Elinor Hortle, Caitlin M. Gillis, Nicole G. Hansbro, Jay C. Horvat, Ligong Liu, Jeffrey Y.W. Mak, James McCluskey, David P. Fairlie, Alexandra J. Corbett, Philip M. Hansbro, Jamie Rossjohn
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (2): e20240896.
https://doi.org/10.1084/jem.20240896
Published: 17 January 2025
View article titled, Cigarette smoke components modulate the MR1–MAIT axis
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Includes: Supplementary data
Journal Articles

Tissue-resident NK cells do their own glandscaping

Jacob A. Myers, Shanelle P. Reilly, Laurent Brossay
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20242253.
https://doi.org/10.1084/jem.20242253
Published: 03 January 2025
View article titled, Tissue-resident NK cells do their own glandscaping
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Journal Articles

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S. Prado, Richard T. Cattley, Andreza B. Sonego, Parth Sutariya, Shuxian Wu, Mijoon Lee, William C. Boggess, Mark J. Shlomchik, William F. Hawse
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20240625.
https://doi.org/10.1084/jem.20240625
Published: 31 December 2024
View article titled, The phospholipid kinase PIKFYVE is essential for Th17 differentiation
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Includes: Supplementary data
Journal Articles

The α glycolipid rules the NKT cell TCR

Mitchell Kronenberg, Gabriel Ascui
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20242099.
https://doi.org/10.1084/jem.20242099
Published: 23 December 2024
View article titled, The α glycolipid rules the NKT cell TCR
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Journal Articles

Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells

Yuki Hosono, Noriyuki Tomiyasu, Hayato Kasai, Eri Ishikawa, Masatomo Takahashi, Akihiro Imamura, Hideharu Ishida, Federica Compostella, Hiroshi Kida, Atsushi Kumanogoh, Takeshi Bamba, Yoshihiro Izumi, Sho Yamasaki
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20240728.
https://doi.org/10.1084/jem.20240728
Published: 20 December 2024
View article titled, Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells
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Includes: Supplementary data
Journal Articles

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

In Special Collection:
Tissue Microenvironment and Immune Memory
Colin Sparano, Darío Solís-Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, Caroline Mussak, Elisa Rallo, Stanislav Dergun, Gioana Litscher, Yishu Xu, Mitchell Bijnen, Christin Friedrich, Melanie Greter, Vanda Juranić Lisnić, Burkhard Becher, Georg Gasteiger, Annette Oxenius, Sonia Tugues
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20240930.
https://doi.org/10.1084/jem.20240930
Published: 18 December 2024
View article titled, Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
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Includes: Supplementary data
Journal Articles

Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

Sonia Tejedor Vaquero, Hadas Neuman, Laura Comerma, Xavi Marcos-Fa, Celia Corral-Vazquez, Mathieu Uzzan, Marc Pybus, Daniel Segura-Garzón, Joana Guerra, Lisa Perruzza, Roser Tachó-Piñot, Jordi Sintes, Adam Rosenstein, Emilie K. Grasset, Mar Iglesias, Monica Gonzalez Farré, Joan Lop, Maria Evangelina Patriaca-Amiano, Monica Larrubia-Loring, Pablo Santiago-Diaz, Júlia Perera-Bel, Pau Berenguer-Molins, Monica Martinez Gallo, Andrea Martin-Nalda, Encarna Varela, Marta Garrido-Pontnou, Fabio Grassi, Francisco Guarner, Saurabh Mehandru, Lucia Márquez-Mosquera, Ramit Mehr, Andrea Cerutti, Giuliana Magri
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20230079.
https://doi.org/10.1084/jem.20230079
Published: 19 November 2024
View article titled, Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease
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Includes: Supplementary data
Journal Articles

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling

In Special Collection:
Tissue Microenvironment and Immune Memory
Calvin Xu, Andreas Obers, Minyi Qin, Alice Brandli, Joelyn Wong, Xin Huang, Allison Clatch, Aly Fayed, Graham Starkey, Rohit D’Costa, Claire L. Gordon, Jeffrey Y.W. Mak, David P. Fairlie, Lynette Beattie, Laura K. Mackay, Dale I. Godfrey, Hui-Fern Koay
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240354.
https://doi.org/10.1084/jem.20240354
Published: 19 November 2024
View article titled, Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling
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Journal Articles

Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency

In Special Collection:
Tissue Microenvironment and Immune Memory
Elena Blanco, Carme Camps, Sameer Bahal, Mohit D. Kerai, Matteo P. Ferla, Adam M. Rochussen, Adam E. Handel, Zainab M. Golwala, Helena Spiridou Goncalves, Susanne Kricke, Fabian Klein, Fang Zhang, Federica Zinghirino, Grace Evans, Thomas M. Keane, Sabrina Lizot, Maaike A.A. Kusters, Mildred A. Iro, Sanjay V. Patel, Emma C. Morris, Siobhan O. Burns, Ruth Radcliffe, Pradeep Vasudevan, Arthur Price, Olivia Gillham, Gabriel E. Valdebenito, Grant S. Stewart, Austen Worth, Stuart P. Adams, Michael Duchen, Isabelle André, David J. Adams, Giorgia Santili, Kimberly C. Gilmour, Georg A. Holländer, E. Graham Davies, Jenny C. Taylor, Gillian M. Griffiths, Adrian J. Thrasher, Fatima Dhalla, Alexandra Y. Kreins
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20220979.
https://doi.org/10.1084/jem.20220979
Published: 19 November 2024
View article titled, Dominant negative variants in <em>ITPR3</em> impair T cell Ca<sup>2+</sup> dynamics causing combined immunodeficiency
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Includes: Supplementary data
Journal Articles

MAIT cells: Conserved watchers on the wall

In Special Collection:
Tissue Microenvironment and Immune Memory
Lilou Germain, Pablo Veloso, Olivier Lantz, François Legoux
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20232298.
https://doi.org/10.1084/jem.20232298
Published: 24 October 2024
View article titled, MAIT cells: Conserved watchers on the wall
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Journal Articles

Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity

In Special Collection:
Tissue Microenvironment and Immune Memory
Hanson Tam, Ying Xu, Jinping An, Torsten Schöneberg, Angela Schulz, Jagan R. Muppidi, Jason G. Cyster
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240992.
https://doi.org/10.1084/jem.20240992
Published: 16 October 2024
View article titled, Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity
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Includes: Supplementary data
Journal Articles

Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity

Deeksha Deep, Herman Gudjonson, Chrysothemis C. Brown, Samuel A. Rose, Roshan Sharma, Yoselin A. Paucar Iza, Seunghee Hong, Saskia Hemmers, Michail Schizas, Zhong-Min Wang, Yuezhou Chen, Duane R. Wesemann, Virginia Pascual, Dana Pe’er, Alexander Y. Rudensky
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231193.
https://doi.org/10.1084/jem.20231193
Published: 25 September 2024
View article titled, Precursor central memory versus effector cell fate and naïve CD4<sup>+</sup> T cell heterogeneity
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Includes: Supplementary data
Journal Articles

SMARCA5-mediated chromatin remodeling is required for germinal center formation

Liat Stoler-Barak, Dominik Schmiedel, Avital Sarusi-Portuguez, Adi Rogel, Ronnie Blecher-Gonen, Zhana Haimon, Tomas Stopka, Ziv Shulman
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240433.
https://doi.org/10.1084/jem.20240433
Published: 19 September 2024
View article titled, SMARCA5-mediated chromatin remodeling is required for germinal center formation
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Includes: Supplementary data
Journal Articles

Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases

In Special Collection:
Cytokines Collection 2024
Praveen Krishna Veerasubramanian, Thomas A. Wynn, Jie Quan, Fridrik J. Karlsson
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240806.
https://doi.org/10.1084/jem.20240806
Published: 19 September 2024
View article titled, Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases
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Includes: Supplementary data
Journal Articles

Interleukin-33–activated basophils promote asthma by regulating Th2 cell entry into lung tissue

In Special Collection:
Cytokines Collection 2024 , 2024: The Year in Experimental Medicine
Martijn J. Schuijs, Claudia M. Brenis Gomez, Fabian Bick, Justine Van Moorleghem, Manon Vanheerswynghels, Geert van Loo, Rudi Beyaert, David Voehringer, Richard M. Locksley, Hamida Hammad, Bart N. Lambrecht
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240103.
https://doi.org/10.1084/jem.20240103
Published: 19 September 2024
View article titled, Interleukin-33–activated basophils promote asthma by regulating Th2 cell entry into lung tissue
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Includes: Supplementary data
Journal Articles

Rediscovering the human thymus through cutting-edge technologies

In Special Collection:
Autoimmunity 2024
Francesca Pala, Luigi D. Notarangelo, Marita Bosticardo
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230892.
https://doi.org/10.1084/jem.20230892
Published: 21 August 2024
View article titled, Rediscovering the human thymus through cutting-edge technologies
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Journal Articles

Transcriptional network dynamics in early T cell development

In Special Collection:
Autoimmunity 2024 , Immunity Review Series
Boyoung Shin, Samantha J. Chang, Brendan W. MacNabb, Ellen V. Rothenberg
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230893.
https://doi.org/10.1084/jem.20230893
Published: 21 August 2024
View article titled, Transcriptional network dynamics in early T cell development
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Journal Articles

ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses

In Special Collection:
Tissue Microenvironment and Immune Memory
Irem Kaymak, McLane J. Watson, Brandon M. Oswald, Shixin Ma, Benjamin K. Johnson, Lisa M. DeCamp, Batsirai M. Mabvakure, Katarzyna M. Luda, Eric H. Ma, Kin Lau, Zhen Fu, Brejnev Muhire, Susan M. Kitchen-Goosen, Alexandra Vander Ark, Michael S. Dahabieh, Bozena Samborska, Matthew Vos, Hui Shen, Zi Peng Fan, Thomas P. Roddy, Gillian A. Kingsbury, Cristovão M. Sousa, Connie M. Krawczyk, Kelsey S. Williams, Ryan D. Sheldon, Susan M. Kaech, Dominic G. Roy, Russell G. Jones
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20231820.
https://doi.org/10.1084/jem.20231820
Published: 16 August 2024
View article titled, ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses
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Includes: Supplementary data
Journal Articles

Immature B cell homing shapes human lymphoid tissue structure and function

Jo Spencer, Chiara Dionisi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20240085.
https://doi.org/10.1084/jem.20240085
Published: 02 August 2024
View article titled, Immature B cell homing shapes human lymphoid tissue structure and function
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Journal Articles

B cell tolerance and autoimmunity: Lessons from repertoires

In Special Collection:
Autoimmunity 2024 , Immunity Review Series
Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20231314.
https://doi.org/10.1084/jem.20231314
Published: 02 August 2024
View article titled, B cell tolerance and autoimmunity: Lessons from repertoires
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