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Journal Articles

JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL

Shifa Khaja Saleem, Sarah Decker, Sandra Kissel, Marcus Bauer, Dmitry Chernyakov, Daniela Bräuer-Hartmann, Konrad Aumann, Claudia Wickenhauser, Marco Herling, Oleksandra Skorobohatko, Nimitha Mathew, Cornelius Schmidt, Claudius Klein, Marie Follo, Christine Dierks

J Exp Med (2024) 222 (1): e20230681.

https://doi.org/10.1084/jem.20230681

Published: 21 November 2024

View article titled, JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL

Includes: Supplementary data

Journal Articles

Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

J Exp Med (2024) 221 (12): e20230079.

https://doi.org/10.1084/jem.20230079

Published: 19 November 2024

View article titled, Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

Includes: Supplementary data

Journal Articles

Aberrant pre-mRNA processing in cancer

Jeetayu Biswas, Leora Boussi, Eytan Stein, Omar Abdel-Wahab

J Exp Med (2024) 221 (11): e20230891.

https://doi.org/10.1084/jem.20230891

Published: 24 September 2024

View article titled, Aberrant pre-mRNA processing in cancer

Journal Articles

SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM)

Ana Portelinha, Shenqiu Wang, Sara Parsa, Man Jiang, Alexander N. Gorelick, Sagarajit Mohanty, Soumya Sharma, Elisa de Stanchina, Marjan Berishaj, Chunying Zhao, James Heward, Neeraj K. Aryal, Omid Tavana, Jiayu Wen, Jude Fitzgibbon, Ahmet Dogan, Anas Younes, Ari M. Melnick, Hans-Guido Wendel

J Exp Med (2024) 221 (10): e20231143.

https://doi.org/10.1084/jem.20231143

Published: 05 September 2024

View article titled, <em>SETD1B</em> mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma

Includes: Supplementary data

Journal Articles

Viable mutations of mouse midnolin suppress B cell malignancies

In Special Collection:

Mechanisms and Models of Cancer 2024

Xue Zhong, Nagesh Peddada, James J. Moresco, Jianhui Wang, Yiao Jiang, Jonathan J. Rios, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler

J Exp Med (2024) 221 (6): e20232132.

https://doi.org/10.1084/jem.20232132

Published: 16 April 2024

View article titled, Viable mutations of mouse midnolin suppress B cell malignancies

Includes: Supplementary data

Journal Articles

Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL

Janneke A. Eken, Marvyn T. Koning, Kristyna Kupcova, Julieta H. Sepúlveda Yáñez, Ruben A.L. de Groen, Edwin Quinten, Jurriaan Janssen, Cornelis A.M. van Bergen, Joost S.P. Vermaat, Arjen Cleven, Marcelo A. Navarrete, Bauke Ylstra, Daphne de Jong, Ondrej Havranek, Hassan Jumaa, Hendrik Veelken

J Exp Med (2024) 221 (5): e20230941.

https://doi.org/10.1084/jem.20230941

Published: 21 March 2024

View article titled, Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL

Includes: Supplementary data

Journal Articles

CAR-T cell manufacturing: Major process parameters and next-generation strategies

In Special Collection:

JEM Cancer Collection 2024 , Cancer Immunotherapy Update 2024

Melanie Ayala Ceja, Mobina Khericha, Caitlin M. Harris, Cristina Puig-Saus, Yvonne Y. Chen

J Exp Med (2024) 221 (2): e20230903.

https://doi.org/10.1084/jem.20230903

Published: 16 January 2024

View article titled, CAR-T cell manufacturing: Major process parameters and next-generation strategies

Journal Articles

Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL

In Special Collection:

Mechanisms and Models of Cancer 2024 , Myeloid Stem Cells and Leukemia 2024 , 2024: The Year in Experimental Medicine

Vincent Fregona, Manon Bayet, Mathieu Bouttier, Laetitia Largeaud, Camille Hamelle, Laura A. Jamrog, Naïs Prade, Stéphanie Lagarde, Sylvie Hebrard, Isabelle Luquet, Véronique Mansat-De Mas, Marie Nolla, Marlène Pasquet, Christine Didier, Ahmed Amine Khamlichi, Cyril Broccardo, Éric Delabesse, Stéphane J.C. Mancini, Bastien Gerby

J Exp Med (2023) 221 (1): e20230279.

https://doi.org/10.1084/jem.20230279

Published: 06 November 2023

View article titled, Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL

Includes: Supplementary data

Journal Articles

Twisted: Escape of epitope-edited healthy cells from immune attack

Laura Volta, Markus G. Manz

J Exp Med (2023) 220 (12): e20231635.

https://doi.org/10.1084/jem.20231635

Published: 11 October 2023

View article titled, Twisted: Escape of epitope-edited healthy cells from immune attack

Journal Articles

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

In Special Collection:

JEM Cancer Collection 2024 , Cancer Immunotherapy Update 2024

J Exp Med (2023) 220 (12): e20231235.

https://doi.org/10.1084/jem.20231235

Published: 29 September 2023

View article titled, Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

Includes: Supplementary data

Journal Articles

Skin mesenchymal niches maintain and protect AML-initiating stem cells

In Special Collection:

Myeloid Stem Cells and Leukemia 2024

Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao, Luana Tomaipitinca, Alma Månsson, Makoto Kondo, Xiaoyan Sun, Anne-Sofie Johansson, Karl Tryggvason, Maria Kasper, Marcus Järås, Hong Qian

J Exp Med (2023) 220 (10): e20220953.

https://doi.org/10.1084/jem.20220953

Published: 26 July 2023

View article titled, Skin mesenchymal niches maintain and protect AML-initiating stem cells

Includes: Supplementary data

Journal Articles

The PML hub: An emerging actor of leukemia therapies

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , JEM Cancer Collection 2024 , Myeloid Stem Cells and Leukemia 2024

Domitille Rérolle, Hugues de Thé

J Exp Med (2023) 220 (8): e20221213.

https://doi.org/10.1084/jem.20221213

Published: 29 June 2023

View article titled, The PML hub: An emerging actor of leukemia therapies

Journal Articles

Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

Ludivine C. Litzler, Astrid Zahn, Kiersten L. Dionne, Adrien Sprumont, Silvana R. Ferreira, Michael R.F. Slattery, Stephen P. Methot, Anne-Marie Patenaude, Steven Hébert, Nisha Kabir, Poorani Ganesh Subramani, Seolkyoung Jung, Stéphane Richard, Claudia L. Kleinman, Javier M. Di Noia

J Exp Med (2023) 220 (9): e20220381.

https://doi.org/10.1084/jem.20220381

Published: 13 June 2023

View article titled, Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

Includes: Supplementary data

Journal Articles

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

In Special Collection:

Hematology and Stem Cells 2023

Yoon-A Kang, Hyojung Paik, Si Yi Zhang, Jonathan J. Chen, Oakley C. Olson, Carl A. Mitchell, Amelie Collins, James W. Swann, Matthew R. Warr, Rong Fan, Emmanuelle Passegué

J Exp Med (2023) 220 (8): e20230088.

https://doi.org/10.1084/jem.20230088

Published: 26 April 2023

View article titled, Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

Includes: Supplementary data

Journal Articles

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

In Special Collection:

Hematology and Stem Cells 2023

Takako Yokomizo-Nakano, Ai Hamashima, Sho Kubota, Jie Bai, Supannika Sorin, Yuqi Sun, Kenta Kikuchi, Mihoko Iimori, Mariko Morii, Akinori Kanai, Atsushi Iwama, Gang Huang, Daisuke Kurotaki, Hitoshi Takizawa, Hirotaka Matsui, Goro Sashida

J Exp Med (2023) 220 (7): e20220962.

https://doi.org/10.1084/jem.20220962

Published: 18 April 2023

View article titled, Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Includes: Supplementary data

Journal Articles

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

In Special Collection:

Thymus, T Cell Development, and Inborn Errors , Hematology and Stem Cells 2023

Hesham D. Abdulla, Raed Alserihi, Christoffer Flensburg, Waruni Abeysekera, Meng-Xiao Luo, Daniel H.D. Gray, Xiaodong Liu, Gordon K. Smyth, Warren S. Alexander, Ian J. Majewski, Matthew P. McCormack

J Exp Med (2023) 220 (6): e20212383.

https://doi.org/10.1084/jem.20212383

Published: 15 March 2023

View article titled, Overexpression of <em>Lmo2</em> initiates T-lymphoblastic leukemia via impaired thymocyte competition

Includes: Supplementary data

Journal Articles

Sidestepping SHP2 inhibition

Bogdan Popescu, Kevin Shannon

J Exp Med (2023) 220 (5): e20230082.

https://doi.org/10.1084/jem.20230082

Published: 03 March 2023

View article titled, Sidestepping SHP2 inhibition

Journal Articles

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

In Special Collection:

JEM Cancer Collection 2023

Wei Wei, Mitchell J. Geer, Xinyi Guo, Igor Dolgalev, Neville E. Sanjana, Benjamin G. Neel

J Exp Med (2023) 220 (5): e20221563.

https://doi.org/10.1084/jem.20221563

Published: 23 February 2023

View article titled, Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

Includes: Supplementary data

Journal Articles

Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

In Special Collection:

Hematology 2022

J Exp Med (2022) 219 (11): e20212228.

https://doi.org/10.1084/jem.20212228

Published: 02 September 2022

View article titled, Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

Includes: Supplementary data

Journal Articles

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

In Special Collection:

Hematology 2022 , JEM Cancer Collection 2023

Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-sze Leung, Albert C. Koong, Amato J. Giaccia

J Exp Med (2022) 219 (9): e20220214.

https://doi.org/10.1084/jem.20220214

Published: 26 July 2022

View article titled, Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

Includes: Supplementary data

NARROW

JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL

Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

Aberrant pre-mRNA processing in cancer

SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma

Viable mutations of mouse midnolin suppress B cell malignancies

Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL

CAR-T cell manufacturing: Major process parameters and next-generation strategies

Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL

Twisted: Escape of epitope-edited healthy cells from immune attack

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

Skin mesenchymal niches maintain and protect AML-initiating stem cells

The PML hub: An emerging actor of leukemia therapies

Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

Sidestepping SHP2 inhibition

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

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