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Journal Articles

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system

Geunhyo Jang, Rosa Park, Eduardo Esteva, Pei-Feng Hsu, Jue Feng, Samik Upadhaya, Catherine M. Sawai, Iannis Aifantis, David R. Fooksman, Boris Reizis
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20240587.
https://doi.org/10.1084/jem.20240587
Published: 12 March 2025
View article titled, Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system
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Includes: Supplementary data
Journal Articles

Native stem cell transcriptional circuits define cardinal features of high-risk leukemia

Qing Wang, Francesco Boccalatte, Jason Xu, Giovanni Gambi, Bettina Nadorp, Fatema Akter, Carea Mullin, Ashley F. Melnick, Elizabeth Choe, Anna C. McCarter, Nicole A. Jerome, Siyi Chen, Karena Lin, Sarah Khan, Rohan Kodgule, Jonathan H. Sussman, Petri Pölönen, Javier Rodriguez-Hernaez, Sonali Narang, Kleopatra Avrampou, Bryan King, Aristotelis Tsirigos, Russell J.H. Ryan, Charles G. Mullighan, David T. Teachey, Kai Tan, Iannis Aifantis, Mark Y. Chiang
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20231349.
https://doi.org/10.1084/jem.20231349
Published: 19 February 2025
View article titled, Native stem cell transcriptional circuits define cardinal features of high-risk leukemia
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Includes: Supplementary data
Journal Articles

Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia

Zhe Chen, Feng Wu, Yan Li, Lei Li, Yufei Lei, Siwei Gao, Tao Chen, Yuxin Xie, Jianwen Xiao, Hanqing Zeng, Jianchuan Deng, Xueya Zhao, Yu Hou
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20241248.
https://doi.org/10.1084/jem.20241248
Published: 21 January 2025
View article titled, Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia
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Includes: Supplementary data
Journal Articles

Spatiotemporal dynamics of fetal liver hematopoietic niches

Márcia Mesquita Peixoto, Francisca Soares-da-Silva, Valentin Bonnet, Yanping Zhou, Gustave Ronteix, Rita Faria Santos, Marie-Pierre Mailhe, Gonçalo Nogueira, Xing Feng, João Pedro Pereira, Emanuele Azzoni, Giorgio Anselmi, Marella F.T.R. de Bruijn, Archibald Perkins, Charles N. Baroud, Perpétua Pinto-do-Ó, Ana Cumano
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (2): e20240592.
https://doi.org/10.1084/jem.20240592
Published: 07 January 2025
View article titled, Spatiotemporal dynamics of fetal liver hematopoietic niches
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Includes: Supplementary data
Journal Articles

Genetic and environmental risks for clonal hematopoiesis and cancer

In Special Collection:
Immunology Update Winter 2025
Stephanie Franco, Lucy A. Godley
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20230931.
https://doi.org/10.1084/jem.20230931
Published: 03 December 2024
View article titled, Genetic and environmental risks for clonal hematopoiesis and cancer
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Journal Articles

Aberrant pre-mRNA processing in cancer

Jeetayu Biswas, Leora Boussi, Eytan Stein, Omar Abdel-Wahab
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (11): e20230891.
https://doi.org/10.1084/jem.20230891
Published: 24 September 2024
View article titled, Aberrant pre-mRNA processing in cancer
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Journal Articles

Transcriptional network dynamics in early T cell development

In Special Collection:
Autoimmunity 2024 , Immunity Review Series
Boyoung Shin, Samantha J. Chang, Brendan W. MacNabb, Ellen V. Rothenberg
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230893.
https://doi.org/10.1084/jem.20230893
Published: 21 August 2024
View article titled, Transcriptional network dynamics in early T cell development
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Journal Articles

Viable mutations of mouse midnolin suppress B cell malignancies

In Special Collection:
Mechanisms and Models of Cancer 2024
Xue Zhong, Nagesh Peddada, James J. Moresco, Jianhui Wang, Yiao Jiang, Jonathan J. Rios, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (6): e20232132.
https://doi.org/10.1084/jem.20232132
Published: 16 April 2024
View article titled, Viable mutations of mouse midnolin suppress B cell malignancies
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Includes: Supplementary data
Journal Articles

Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions

In Special Collection:
Myeloid Stem Cells and Leukemia 2024
Michael Solomon, Baobao Song, Vinothini Govindarajah, Samantha Good, Ashok Arasu, E. Broderick Hinton, Kairavee Thakkar, James Bartram, Marie-Dominique Filippi, Jose A. Cancelas, Nathan Salomonis, H. Leighton Grimes, Damien Reynaud
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20231035.
https://doi.org/10.1084/jem.20231035
Published: 01 November 2023
View article titled, Slow cycling and durable Flt3<sup>+</sup> progenitors contribute to hematopoiesis under native conditions
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Includes: Supplementary data
Journal Articles

Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection

In Special Collection:
Myeloid Stem Cells and Leukemia 2024
Tengfei Song, Yonghong Yao, Julien Papoin, Barbara Sherry, Betty Diamond, Hua Gu, Lionel Blanc, Yong-Rui Zou
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20230018.
https://doi.org/10.1084/jem.20230018
Published: 18 October 2023
View article titled, Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection
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Includes: Supplementary data
Journal Articles

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development

Sarah Gruenbacher, Markus Jaritz, Louisa Hill, Markus Schäfer, Meinrad Busslinger
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20230260.
https://doi.org/10.1084/jem.20230260
Published: 19 September 2023
View article titled, Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development
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Includes: Supplementary data
Journal Articles

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

In Special Collection:
JEM Cancer Collection 2024 , 2023: The Year in Experimental Medicine
Yang Feng, Qingchen Yuan, Rachel C. Newsome, Troy Robinson, Robert L. Bowman, Ashley N. Zuniga, Kendra N. Hall, Cassandra M. Bernsten, Daniil E. Shabashvili, Kathryn I. Krajcik, Chamara Gunaratne, Zachary J. Zaroogian, Kartika Venugopal, Heidi L. Casellas Roman, Ross L. Levine, Walid K. Chatila, Rona Yaeger, Alberto Riva, Christian Jobin, Daniel Kopinke, Dorina Avram, Olga A. Guryanova
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (11): e20230011.
https://doi.org/10.1084/jem.20230011
Published: 24 August 2023
View article titled, Hematopoietic-specific heterozygous loss of <em>Dnmt3a</em> exacerbates colitis-associated colon cancer
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Includes: Supplementary data
Journal Articles

Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis

In Special Collection:
Immunometabolism 2024 , Myeloid Stem Cells and Leukemia 2024
Hannah A. Pizzato, Yahui Wang, Michael J. Wolfgang, Brian N. Finck, Gary J. Patti, Deepta Bhattacharya
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (9): e20221373.
https://doi.org/10.1084/jem.20221373
Published: 30 May 2023
View article titled, Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis
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Journal Articles

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

In Special Collection:
Hematology and Stem Cells 2023
Yoon-A Kang, Hyojung Paik, Si Yi Zhang, Jonathan J. Chen, Oakley C. Olson, Carl A. Mitchell, Amelie Collins, James W. Swann, Matthew R. Warr, Rong Fan, Emmanuelle Passegué
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (8): e20230088.
https://doi.org/10.1084/jem.20230088
Published: 26 April 2023
View article titled, Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
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Includes: Supplementary data
Journal Articles

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

In Special Collection:
Hematology and Stem Cells 2023
Takako Yokomizo-Nakano, Ai Hamashima, Sho Kubota, Jie Bai, Supannika Sorin, Yuqi Sun, Kenta Kikuchi, Mihoko Iimori, Mariko Morii, Akinori Kanai, Atsushi Iwama, Gang Huang, Daisuke Kurotaki, Hitoshi Takizawa, Hirotaka Matsui, Goro Sashida
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (7): e20220962.
https://doi.org/10.1084/jem.20220962
Published: 18 April 2023
View article titled, Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs
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Includes: Supplementary data
Journal Articles

CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment

In Special Collection:
Hematology and Stem Cells 2023
Lisiena Hysenaj, Bérengère de Laval, Vilma Arce-Gorvel, Mile Bosilkovski, Gabriela González-Espinoza, Guilhaume Debroas, Michael H. Sieweke, Sandrine Sarrazin, Jean-Pierre Gorvel
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (7): e20210567.
https://doi.org/10.1084/jem.20210567
Published: 17 April 2023
View article titled, CD150-dependent hematopoietic stem cell sensing of <em>Brucella</em> instructs myeloid commitment
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Journal Articles

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1

In Special Collection:
Thymus, T Cell Development, and Inborn Errors , Hematology and Stem Cells 2023
Seeyoung Choi, Teri Hatzihristidis, Guillaume Gaud, Avik Dutta, Jan Lee, Awadhesh Arya, Lauren M. Clubb, Daniel B. Stamos, Adrienn Markovics, Katalin Mikecz, Paul Love
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (7): e20221649.
https://doi.org/10.1084/jem.20221649
Published: 17 April 2023
View article titled, GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
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Includes: Supplementary data
Journal Articles

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

In Special Collection:
Thymus, T Cell Development, and Inborn Errors , Hematology and Stem Cells 2023
Hesham D. Abdulla, Raed Alserihi, Christoffer Flensburg, Waruni Abeysekera, Meng-Xiao Luo, Daniel H.D. Gray, Xiaodong Liu, Gordon K. Smyth, Warren S. Alexander, Ian J. Majewski, Matthew P. McCormack
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (6): e20212383.
https://doi.org/10.1084/jem.20212383
Published: 15 March 2023
View article titled, Overexpression of <em>Lmo2</em> initiates T-lymphoblastic leukemia via impaired thymocyte competition
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Includes: Supplementary data
Journal Articles

Sleep exerts lasting effects on hematopoietic stem cell function and diversity

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Hematology 2022 , 2022: The Year in Experimental Medicine
Cameron S. McAlpine, Máté G. Kiss, Faris M. Zuraikat, David Cheek, Giulia Schiroli, Hajera Amatullah, Pacific Huynh, Mehreen Z. Bhatti, Lai-Ping Wong, Abi G. Yates, Wolfram C. Poller, John E. Mindur, Christopher T. Chan, Henrike Janssen, Jeffrey Downey, Sumnima Singh, Ruslan I. Sadreyev, Matthias Nahrendorf, Kate L. Jeffrey, David T. Scadden, Kamila Naxerova, Marie-Pierre St-Onge, Filip K. Swirski
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (11): e20220081.
https://doi.org/10.1084/jem.20220081
Published: 21 September 2022
View article titled, Sleep exerts lasting effects on hematopoietic stem cell function and diversity
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Includes: Supplementary data
Journal Articles

Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

In Special Collection:
Hematology 2022
Chong Yang, Rui Yokomori, Lee Hui Chua, Shi Hao Tan, Darren Qiancheng Tan, Kenichi Miharada, Takaomi Sanda, Toshio Suda
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (12): e20220685.
https://doi.org/10.1084/jem.20220685
Published: 16 September 2022
View article titled, Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47
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