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Journal Articles

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

In Special Collection:

Innate Immune Cells and Signaling 2023

J Exp Med (2022) 220 (1): e20220829.

https://doi.org/10.1084/jem.20220829

Published: 08 November 2022

View article titled, Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Includes: Supplementary data

Journal Articles

Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire

Danielle J. Dauphars, Ariana Mihai, Liuyang Wang, Yuan Zhuang, Michael S. Krangel

J Exp Med (2021) 219 (2): e20211581.

https://doi.org/10.1084/jem.20211581

Published: 15 December 2021

View article titled, Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire

Journal Articles

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

Helen A. Beilinson, Rebecca A. Glynn, Anurupa Devi Yadavalli, Jianxiong Xiao, Elizabeth Corbett, Huseyin Saribasak, Rahul Arya, Charline Miot, Anamika Bhattacharyya, Jessica M. Jones, Jagan M.R. Pongubala, Craig H. Bassing, David G. Schatz

J Exp Med (2021) 218 (10): e20210250.

https://doi.org/10.1084/jem.20210250

Published: 17 August 2021

View article titled, The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

Includes: Supplementary data

Journal Articles

Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10

In Special Collection:

JEM Cancer Immunotherapy 2021 , Mechanisms and Models of Cancer 2022 Update

Courtney Mowat, Shayla R. Mosley, Afshin Namdar, Daniel Schiller, Kristi Baker

J Exp Med (2021) 218 (9): e20210108.

https://doi.org/10.1084/jem.20210108

Published: 23 July 2021

View article titled, Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10

Includes: Supplementary data

Journal Articles

Sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) activity is required for V(D)J recombination

Chun-Chin Chen, Bo-Ruei Chen, Yinan Wang, Philip Curman, Helen A. Beilinson, Ryan M. Brecht, Catherine C. Liu, Ryan J. Farrell, Jaime de Juan-Sanz, Louis-Marie Charbonnier, Shingo Kajimura, Timothy A. Ryan, David G. Schatz, Talal A. Chatila, Jakob D. Wikstrom, Jessica K. Tyler, Barry P. Sleckman

J Exp Med (2021) 218 (8): e20201708.

https://doi.org/10.1084/jem.20201708

Published: 25 May 2021

View article titled, Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination

Includes: Supplementary data

Journal Articles

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

J Exp Med (2020) 218 (3): e20200622.

https://doi.org/10.1084/jem.20200622

Published: 14 December 2020

View article titled, ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

Includes: Supplementary data

Journal Articles

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Emily K. Law, Rena Levin-Klein, Matthew C. Jarvis, Hyoung Kim, Prokopios P. Argyris, Michael A. Carpenter, Gabriel J. Starrett, Nuri A. Temiz, Lindsay K. Larson, Cameron Durfee, Michael B. Burns, Rachel I. Vogel, Spyridon Stavrou, Alexya N. Aguilera, Sandra Wagner, David A. Largaespada, Timothy K. Starr, Susan R. Ross, Reuben S. Harris

J Exp Med (2020) 217 (12): e20200261.

https://doi.org/10.1084/jem.20200261

Published: 01 September 2020

View article titled, APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Journal Articles

Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome

J Exp Med (2020) 217 (11): e20191688.

https://doi.org/10.1084/jem.20191688

Published: 31 August 2020

View article titled, Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome

Includes: Supplementary data

Journal Articles

RSSs set the odds for exclusion

Michael S. Krangel

J Exp Med (2020) 217 (9): e20200831.

https://doi.org/10.1084/jem.20200831

Published: 13 August 2020

View article titled, RSSs set the odds for exclusion

Journal Articles

CtIP is essential for early B cell proliferation and development in mice

Xiangyu Liu, Xiaobin S. Wang, Brian J. Lee, Foon K. Wu-Baer, Xiaohui Lin, Zhengping Shao, Verna M. Estes, Jean Gautier, Richard Baer, Shan Zha

J Exp Med (2019) 216 (7): 1648–1663.

https://doi.org/10.1084/jem.20181139

Published: 16 May 2019

View article titled, CtIP is essential for early B cell proliferation and development in mice

Includes: Supplementary data

Journal Articles

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

Matthieu Gratia, Mathieu P. Rodero, Cécile Conrad, Elias Bou Samra, Mathieu Maurin, Gillian I. Rice, Darragh Duffy, Patrick Revy, Florence Petit, Russell C. Dale, Yanick J. Crow, Mounira Amor-Gueret, Nicolas Manel

J Exp Med (2019) 216 (5): 1199–1213.

https://doi.org/10.1084/jem.20181329

Published: 01 April 2019

View article titled, Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

Includes: Supplementary data

Journal Articles

Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene

Yunxiang Mu, Monika A. Zelazowska, Kevin M. McBride

J Exp Med (2017) 214 (12): 3543–3552.

https://doi.org/10.1084/jem.20170468

Published: 09 November 2017

View article titled, Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene

Includes: Supplementary data

Journal Articles

RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis

In Special Collection:

Tumor Metabolism

Yan Xia, Weiwei Yang, Ming Fa, Xinjian Li, Yugang Wang, Yuhui Jiang, Yanhua Zheng, Jong-Ho Lee, Jing Li, Zhimin Lu

J Exp Med (2017) 214 (6): 1843–1855.

https://doi.org/10.1084/jem.20170015

Published: 15 May 2017

View article titled, RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis

Includes: Supplementary data

Journal Articles

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs

Giulia Girelli Zubani, Marija Zivojnovic, Annie De Smet, Olivier Albagli-Curiel, François Huetz, Jean-Claude Weill, Claude-Agnès Reynaud, Sébastien Storck

J Exp Med (2017) 214 (4): 1169–1180.

https://doi.org/10.1084/jem.20161576

Published: 10 March 2017

View article titled, Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs

Includes: Supplementary data

Journal Articles

RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks

Philipp C. Rommel, Thiago Y. Oliveira, Michel C. Nussenzweig, Davide F. Robbiani

J Exp Med (2017) 214 (3): 815–831.

https://doi.org/10.1084/jem.20161638

Published: 08 February 2017

View article titled, RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks

Includes: Supplementary data

Journal Articles

The cell cycle restricts activation-induced cytidine deaminase activity to early G1

Qiao Wang, Kyong-Rim Kieffer-Kwon, Thiago Y. Oliveira, Christian T. Mayer, Kaihui Yao, Joy Pai, Zhen Cao, Marei Dose, Rafael Casellas, Mila Jankovic, Michel C. Nussenzweig, Davide F. Robbiani

J Exp Med (2016) 214 (1): 49–58.

https://doi.org/10.1084/jem.20161649

Published: 20 December 2016

View article titled, The cell cycle restricts activation-induced cytidine deaminase activity to early G1

Includes: Supplementary data

Journal Articles

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

Yee Ling Wu, Michael J.T. Stubbington, Maria Daly, Sarah A. Teichmann, Cristina Rada

J Exp Med (2016) 214 (1): 183–196.

https://doi.org/10.1084/jem.20161056

Published: 19 December 2016

View article titled, Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

Includes: Supplementary data

Journal Articles

UNG protects B cells from AID-induced telomere loss

Elena M. Cortizas, Astrid Zahn, Shiva Safavi, Joseph A. Reed, Francisco Vega, Javier M. Di Noia, Ramiro E. Verdun

J Exp Med (2016) 213 (11): 2459–2472.

https://doi.org/10.1084/jem.20160635

Published: 03 October 2016

View article titled, UNG protects B cells from AID-induced telomere loss

NARROW

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10

Sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) activity is required for V(D)J recombination

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome

RSSs set the odds for exclusion

CtIP is essential for early B cell proliferation and development in mice

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene

RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs

RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks

The cell cycle restricts activation-induced cytidine deaminase activity to early G1

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

UNG protects B cells from AID-induced telomere loss

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