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Journal Articles

Uniting education, research, healthcare, and society to advance women’s heart health

Michael Y. Schakelaar, Annemieke Maas, Anne-Mar L.N. van Ommen, Anna E. Spiering, Roos de Jonge, Patrick Wijchers, Gerda van Rossum, Balthasar A. Heesters, Olivier G. de Jong, Jelle Zandveld, Heggert G. Rebel, Jan Meeldijk, Emma W. Pijnappel, Suzanne van Dijk, Alessia Di Maggio, Olaf Nijssen, Jorine G.F. Sanders, Lies Hoogerwerf, Mike van Spaandonk, Sandra Crnko, Thijs Koorman, Kevin Jenniskens, N. Charlotte Onland-Moret, Stefan M. van Geelen, Toine ten Broeke, Annet van Royen-Kerkhof, Gönül Dilaver, Sabrina Oliveira, Robbert J. Kok, Linda W. van Laake, Pim van der Harst, Wilko Spiering, Frans H. Rutten, Marco van Brussel, Hester M. den Ruijter, Niels Bovenschen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240877.
https://doi.org/10.1084/jem.20240877
Published: 15 October 2024
View article titled, Uniting education, research, healthcare, and society to advance women’s heart health
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Journal Articles

Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension

Maki Niihori, Joel James, Mathews V. Varghese, Nolan McClain, Odunayo Susan Lawal, Rohit C. Philip, Brenda K. Baggett, Dmitry A. Goncharov, Vinicio de Jesus Perez, Elena A. Goncharova, Ruslan Rafikov, Olga Rafikova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231568.
https://doi.org/10.1084/jem.20231568
Published: 25 September 2024
View article titled, Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension
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Includes: Supplementary data
Journal Articles

Meningeal lymphatics can influence stroke outcome

Gou Young Koh, Donald M. McDonald
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20232305.
https://doi.org/10.1084/jem.20232305
Published: 05 March 2024
View article titled, Meningeal lymphatics can influence stroke outcome
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Journal Articles

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine
Ligia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee, Basavaraju G. Sanganahalli, Myriam Spajer, Shenqi Zhang, Sungwoon Lee, Maxime Parent, Yuechuan Xue, Mario Skarica, Xiangyun Yin, Justine Guegan, Kevin Boyé, Felipe Saceanu Leser, Laurent Jacob, Mathilde Poulet, Mingfeng Li, Xiaodan Liu, Sofia E. Velazquez, Ruchith Singhabahu, Mark E. Robinson, Michael H. Askenase, Artem Osherov, Nenad Sestan, Jiangbing Zhou, Kari Alitalo, Eric Song, Anne Eichmann, Lauren H. Sansing, Helene Benveniste, Fahmeed Hyder, Jean-Leon Thomas
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221983.
https://doi.org/10.1084/jem.20221983
Published: 05 March 2024
View article titled, VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
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Includes: Supplementary data
Journal Articles

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

In Special Collection:
Barrier Immunity , Immunology Update Winter 2024
Harald Lund, Matthew A. Hunt, Zerina Kurtović, Katalin Sandor, Paul B. Kägy, Noah Fereydouni, Anais Julien, Christian Göritz, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Alexandra Jurczak, Jinming Han, Keying Zhu, Robert A. Harris, Jon Lampa, Jonas Heilskov Graversen, Anders Etzerodt, Lisbet Haglund, Tony L. Yaksh, Camilla I. Svensson
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (2): e20230675.
https://doi.org/10.1084/jem.20230675
Published: 20 December 2023
View article titled, CD163<sup>+</sup> macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
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Includes: Supplementary data
Journal Articles

Mechanisms and functions of intestinal vascular specialization

In Special Collection:
Lymphatic Vessels in Health and Disease 2024
Jeremiah Bernier-Latmani, Alejandra González-Loyola, Tatiana V. Petrova
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20222008.
https://doi.org/10.1084/jem.20222008
Published: 05 December 2023
View article titled, Mechanisms and functions of intestinal vascular specialization
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Journal Articles

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

In Special Collection:
Lymphatic Vessels in Health and Disease 2024
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsäter, Michael Vanlandewijck, Bojana Jakic, Eulàlia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Mäkinen
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (4): e20220741.
https://doi.org/10.1084/jem.20220741
Published: 23 January 2023
View article titled, Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
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Includes: Supplementary data
Journal Articles

Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies

In Special Collection:
Innate Immune Cells and Signaling 2023
Achraf Shamseddine, Suchit H. Patel, Valery Chavez, Zachary R. Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T. Dang, Lakshmi V. Ramanathan, Kevin C. Oeffinger, Jennifer E. Liu, Richard M. Steingart, Alessandra Piersigilli, Nicholas D. Socci, Angel T. Chan, Anthony F. Yu, Samuel F. Bakhoum, Adam M. Schmitt
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (3): e20220809.
https://doi.org/10.1084/jem.20220809
Published: 19 December 2022
View article titled, Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies
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Includes: Supplementary data
Journal Articles

Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice

Corinne M. Nielsen, Xuetao Zhang, Kunal Raygor, Shaoxun Wang, Andrew W. Bollen, Rong A. Wang
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20211390.
https://doi.org/10.1084/jem.20211390
Published: 28 November 2022
View article titled, Endothelial <em>Rbpj</em> deletion normalizes Notch4-induced brain arteriovenous malformation in mice
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Journal Articles

Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury

Hao He, Wu Yang, Nan Su, Chuankai Zhang, Jianing Dai, Feng Han, Mahak Singhal, Wenjuan Bai, Xiaolan Zhu, Jing Zhu, Zhen Liu, Wencheng Xia, Xiaoting Liu, Chonghe Zhang, Kai Jiang, Wenhui Huang, Dan Chen, Zhaoyin Wang, Xueyang He, Frank Kirchhoff, Zhenyu Li, Cong Liu, Jingning Huan, Xiaohong Wang, Wu Wei, Jing Wang, Hellmut G. Augustin, Junhao Hu
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20211422.
https://doi.org/10.1084/jem.20211422
Published: 09 November 2022
View article titled, Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury
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Includes: Supplementary data
Journal Articles

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schölch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut G. Augustin, Moritz Felcht
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (1): e20202595.
https://doi.org/10.1084/jem.20202595
Published: 21 October 2022
View article titled, Primary tumor–derived systemic nANGPTL4 inhibits metastasis
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Includes: Supplementary data
Journal Articles

CARD8 makes coxsackievirus more “heartbreaking”

Qiankun Wang, Liang Shan
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (10): e20221240.
https://doi.org/10.1084/jem.20221240
Published: 21 September 2022
View article titled, CARD8 makes coxsackievirus more “heartbreaking”
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Journal Articles

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

In Special Collection:
JEM Clinical Immunology Collection 2023 , 2022: The Year in Experimental Medicine
Rhea Nadkarni, Wern Cui Chu, Cheryl Q.E. Lee, Yasir Mohamud, Lynn Yap, Gee Ann Toh, Sheryl Beh, Radiance Lim, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Kim Robinson, Karl Tryggvason, Honglin Luo, Franklin Zhong, Lena Ho
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (10): e20212117.
https://doi.org/10.1084/jem.20212117
Published: 21 September 2022
View article titled, Viral proteases activate the CARD8 inflammasome in the human cardiovascular system
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Includes: Supplementary data
Journal Articles

CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

In Special Collection:
Fibrosis Collection 2023
Yang Zhang, Yicong Ye, Xiaoqiang Tang, Hui Wang, Toshiko Tanaka, Ran Tian, Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu, Ye Jin, Haiyu Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, Ruijia Dong, Luigi Ferrucci, Zhuang Tian, Shuyang Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (8): e20200418.
https://doi.org/10.1084/jem.20200418
Published: 10 June 2022
View article titled, CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure
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Includes: Supplementary data
Journal Articles

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice

Tomoko Matsubara, Takahito Iga, Yuki Sugiura, Dai Kusumoto, Tsukasa Sanosaka, Ikue Tai-Nagara, Norihiko Takeda, Guo-Hua Fong, Kosei Ito, Masatsugu Ema, Hideyuki Okano, Jun Kohyama, Makoto Suematsu, Yoshiaki Kubota
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (4): e20211789.
https://doi.org/10.1084/jem.20211789
Published: 23 March 2022
View article titled, Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice
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Includes: Supplementary data
Journal Articles

Yolk sac steps up to the plate

Hanna K.A. Mikkola
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (3): e20212315.
https://doi.org/10.1084/jem.20212315
Published: 24 February 2022
View article titled, Yolk sac steps up to the plate
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Journal Articles

Vascular heterogeneity: VEGF receptors make blood vessels special

Pin Li, Napoleone Ferrara
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (3): e20212539.
https://doi.org/10.1084/jem.20212539
Published: 27 January 2022
View article titled, Vascular heterogeneity: VEGF receptors make blood vessels special
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Journal Articles

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

In Special Collection:
Lymphatic Vessels in Health and Disease 2022
Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (3): e20210565.
https://doi.org/10.1084/jem.20210565
Published: 20 January 2022
View article titled, Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
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Includes: Supplementary data
Journal Articles

Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation

In Special Collection:
JEM Stroke Immunology Collection 2022
Jing Li, Tripti Kumari, Andrew Barazia, Vishwanath Jha, Si-Yeon Jeong, Amber Olson, Mijeong Kim, Bum-Kyu Lee, Vijayprakash Manickam, Zhimin Song, Regina Clemens, Babak Razani, Jonghwan Kim, Mary C. Dinauer, Jaehyung Cho
Journal: Journal of Experimental Medicine
J Exp Med (2021) 219 (1): e20211083.
https://doi.org/10.1084/jem.20211083
Published: 09 November 2021
View article titled, Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation
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Includes: Supplementary data
Journal Articles

Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation

Sarah C. Huen, Andrew Wang, Kyle Feola, Reina Desrouleaux, Harding H. Luan, Richard Hogg, Cuiling Zhang, Qing-Jun Zhang, Zhi-Ping Liu, Ruslan Medzhitov
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (10): e20202151.
https://doi.org/10.1084/jem.20202151
Published: 18 August 2021
View article titled, Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation
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