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Journal Articles

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241188.
https://doi.org/10.1084/jem.20241188
Published: 14 April 2025
View articletitled, Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity
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Includes: Supplementary data
Journal Articles

Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design

Kevin Groen, Roger Kuratli, Jannik Enkelmann, Sonja Fernbach, Pedro D. Wendel-Garcia, Willy I. Staiger, Marylène Lejeune, Esther Sauras-Colón, Ferran Roche-Campo, Paraskevas Filippidis, Andri Rauch, Swiss HIV Cohort Study, Alexandra Trkola, Huldrych F. Günthard, Roger D. Kouyos, Silvio D. Brugger, Benjamin G. Hale
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20242039.
https://doi.org/10.1084/jem.20242039
Published: 20 March 2025
View articletitled, Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design
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Includes: Supplementary data
Journal Articles

The common HAQ STING allele prevents clinical penetrance of COPA syndrome

In Special Collection:
Genes and Immunity
Noa Simchoni, Shogo Koide, Maryel Likhite, Yoshihiko Kuchitsu, Senkottuvelan Kadirvel, Christopher S. Law, Brett M. Elicker, Santosh Kurra, Margaret Mei-Kay Wong, Bo Yuan, Alice Grossi, Ronald M. Laxer, Stefano Volpi, Dilan Dissanayake, Tomohiko Taguchi, David B. Beck, Tiphanie P. Vogel, Anthony K. Shum
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20242179.
https://doi.org/10.1084/jem.20242179
Published: 27 February 2025
View articletitled, The common HAQ STING allele prevents clinical penetrance of COPA syndrome
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Includes: Supplementary data
Journal Articles

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

Devon Jeltema, Kennady Knox, Nicole Dobbs, Zhen Tang, Cong Xing, Antonina Araskiewicz, Kun Yang, Ivan Rodriguez Siordia, Jason Matthews, Michael Cohen, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241184.
https://doi.org/10.1084/jem.20241184
Published: 19 February 2025
View articletitled, PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
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Includes: Supplementary data
Journal Articles

pDCs, type 1 IFN, and the female predileXion of SSc

Nikhil Jiwrajka, Montserrat C. Anguera
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20242284.
https://doi.org/10.1084/jem.20242284
Published: 17 January 2025
View articletitled, pDCs, type 1 IFN, and the female predileXion of SSc
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Journal Articles

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans

In Special Collection:
Genes and Immunity
Quentin Riller, Boris Sorin, Charline Courteille, Duong Ho-Nhat, Tom Le Voyer, Jean-Christophe Debray, Marie-Claude Stolzenberg, Muriel Schmutz, Olivier Pellé, Thomas Becquard, María Rodrigo Riestra, Laureline Berteloot, Mélanie Migaud, Laure Delage, Marie Jeanpierre, Charlotte Boussard, Camille Brunaud, Aude Magérus, Charles Bretot, Victor Michel, Camille Roux, Capucine Picard, Cécile Masson, Christine Bole-Feysot, Nicolas Cagnard, Aurélien Corneau, Isabelle Meyts, Véronique Baud, Jean-Laurent Casanova, Alain Fischer, Emmanuel Dejardin, Anne Puel, Cécile Boulanger, Bénédicte Neven, Frédéric Rieux-Laucat
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (2): e20240843.
https://doi.org/10.1084/jem.20240843
Published: 15 January 2025
View articletitled, Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
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Includes: Supplementary data
Journal Articles

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S. Prado, Richard T. Cattley, Andreza B. Sonego, Parth Sutariya, Shuxian Wu, Mijoon Lee, William C. Boggess, Mark J. Shlomchik, William F. Hawse
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20240625.
https://doi.org/10.1084/jem.20240625
Published: 31 December 2024
View articletitled, The phospholipid kinase PIKFYVE is essential for Th17 differentiation
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Includes: Supplementary data
Journal Articles

Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis

Yong Du, Bérénice Faz-Lopez, Marie Dominique Ah Kioon, Claire Cenac, Michael Pierides, Kimberly S. Lakin, Robert F. Spiera, Julie Chaumeil, Marie-Elise Truchetet, Jessica K. Gordon, Jean-Charles Guéry, Franck J. Barrat
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20231809.
https://doi.org/10.1084/jem.20231809
Published: 13 December 2024
View articletitled, Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis
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Includes: Supplementary data
Journal Articles

Antiviral immunity lassoed down by excess RNA

Erika Valeri, Anna Kajaste-Rudnitski
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241743.
https://doi.org/10.1084/jem.20241743
Published: 06 December 2024
View articletitled, Antiviral immunity lassoed down by excess RNA
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Journal Articles

The brain–eye connection: More than just action potentials

James Walsh
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20241519.
https://doi.org/10.1084/jem.20241519
Published: 10 October 2024
View articletitled, The brain–eye connection: More than just action potentials
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Journal Articles

Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases

Jérémie Rosain, Tom Le Voyer, Xian Liu, Adrian Gervais, Laura Polivka, Axel Cederholm, Laureline Berteloot, Audrey V. Parent, Alessandra Pescatore, Ezia Spinosa, Snezana Minic, Ana Elisa Kiszewski, Miyuki Tsumura, Chloé Thibault, Maria Esnaola Azcoiti, Jelena Martinovic, Quentin Philippot, Taushif Khan, Astrid Marchal, Bénédicte Charmeteau-De Muylder, Lucy Bizien, Caroline Deswarte, Lillia Hadjem, Marie-Odile Fauvarque, Karim Dorgham, Daniel Eriksson, Emilia Liana Falcone, Mathilde Puel, Sinem Ünal, Amyrath Geraldo, Corentin Le Floc’h, Hailun Li, Sylvie Rheault, Christine Muti, Claire Bobrie-Moyrand, Anne Welfringer-Morin, Ramsay L. Fuleihan, Romain Lévy, Marie Roelens, Liwei Gao, Marie Materna, Silvia Pellegrini, Lorenzo Piemonti, Emilie Catherinot, Jean-Christophe Goffard, Arnaud Fekkar, Aissata Sacko-Sow, Camille Soudée, Soraya Boucherit, Anna-Lena Neehus, Cristina Has, Stefanie Hübner, Géraldine Blanchard-Rohner, Blanca Amador-Borrero, Takanori Utsumi, Maki Taniguchi, Hiroo Tani, Kazushi Izawa, Takahiro Yasumi, Sotaro Kanai, Mélanie Migaud, Mélodie Aubart, Nathalie Lambert, Guy Gorochov, Capucine Picard, Claire Soudais, Anne-Sophie L’Honneur, Flore Rozenberg, Joshua D. Milner, Shen-Ying Zhang, Pierre Vabres, Dusan Trpinac, Nico Marr, Nathalie Boddaert, Isabelle Desguerre, Manolis Pasparakis, Corey N. Miller, Cláudia S. Poziomczyk, Laurent Abel, Satoshi Okada, Emmanuelle Jouanguy, Rémi Cheynier, Qian Zhang, Aurélie Cobat, Vivien Béziat, Bertrand Boisson, Julie Steffann, Francesca Fusco, Matilde Valeria Ursini, Smail Hadj-Rabia, Christine Bodemer, Jacinta Bustamante, Hervé Luche, Anne Puel, Gilles Courtois, Paul Bastard, Nils Landegren, Mark S. Anderson, Jean-Laurent Casanova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231152.
https://doi.org/10.1084/jem.20231152
Published: 01 October 2024
View articletitled, Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases
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Includes: Supplementary data
Journal Articles

Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity

Deeksha Deep, Herman Gudjonson, Chrysothemis C. Brown, Samuel A. Rose, Roshan Sharma, Yoselin A. Paucar Iza, Seunghee Hong, Saskia Hemmers, Michail Schizas, Zhong-Min Wang, Yuezhou Chen, Duane R. Wesemann, Virginia Pascual, Dana Pe’er, Alexander Y. Rudensky
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (10): e20231193.
https://doi.org/10.1084/jem.20231193
Published: 25 September 2024
View articletitled, Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity
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Includes: Supplementary data
Journal Articles

Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases

In Special Collection:
Multifaceted B Cell Functions and Dysfunctions , Cytokines Collection 2024
Praveen Krishna Veerasubramanian, Thomas A. Wynn, Jie Quan, Fridrik J. Karlsson
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240806.
https://doi.org/10.1084/jem.20240806
Published: 19 September 2024
View articletitled, Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases
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Includes: Supplementary data
Journal Articles

The partitioning of TCR repertoires by thymic selection

In Special Collection:
Autoimmunity 2024
Wan-Lin Lo, Eric S. Huseby
Journal: Journal of Experimental Medicine
Series: Thymus and T Cell Development Focus
J Exp Med (2024) 221 (10): e20230897.
https://doi.org/10.1084/jem.20230897
Published: 21 August 2024
View articletitled, The partitioning of TCR repertoires by thymic selection
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Journal Articles

B cell tolerance and autoimmunity: Lessons from repertoires

In Special Collection:
Autoimmunity 2024 , Immunity Review Series
Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20231314.
https://doi.org/10.1084/jem.20231314
Published: 02 August 2024
View articletitled, B cell tolerance and autoimmunity: Lessons from repertoires
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Journal Articles

The RNA binding protein Arid5a drives IL-17–dependent autoantibody-induced glomerulonephritis

In Special Collection:
Cytokines Collection 2024
Yang Li, Shachi P. Vyas, Isha Mehta, Nariaki Asada, Ipsita Dey, Tiffany C. Taylor, Rami Bechara, Nilesh Amatya, Felix E.Y. Aggor, Bianca M. Coleman, De-Dong Li, Kenta Yamamoto, Ogechukwu Ezenwa, Yeque Sun, Esta Sterneck, C. Joel McManus, Ulf Panzer, Partha S. Biswas, Ram Savan, Jishnu Das, Sarah L. Gaffen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20240656.
https://doi.org/10.1084/jem.20240656
Published: 26 July 2024
View articletitled, The RNA binding protein Arid5a drives IL-17–dependent autoantibody-induced glomerulonephritis
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Includes: Supplementary data
Journal Articles

Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus

In Special Collection:
Autoimmunity 2024
Marie Jeanpierre, Jade Cognard, Maud Tusseau, Quentin Riller, Linh-Chi Bui, Jérémy Berthelet, Audrey Laurent, Etienne Crickx, Marianna Parlato, Marie-Claude Stolzenberg, Felipe Suarez, Guy Leverger, Nathalie Aladjidi, Sophie Collardeau-Frachon, Christine Pietrement, Marion Malphettes, Antoine Froissart, Christine Bole-Feysot, Nicolas Cagnard, Fernando Rodrigues Lima, Thierry Walzer, Frédéric Rieux-Laucat, Alexandre Belot, Anne-Laure Mathieu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20232337.
https://doi.org/10.1084/jem.20232337
Published: 19 July 2024
View articletitled, Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus
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Includes: Supplementary data
Journal Articles

Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies

In Special Collection:
Cytokines Collection 2024
Sonja Fernbach, Nina K. Mair, Irene A. Abela, Kevin Groen, Roger Kuratli, Marie Lork, Christian W. Thorball, Enos Bernasconi, Paraskevas Filippidis, Karoline Leuzinger, Julia Notter, Andri Rauch, Hans H. Hirsch, Michael Huber, Huldrych F. Günthard, Jacques Fellay, Roger D. Kouyos, Benjamin G. Hale, The Swiss HIV Cohort Study
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20240365.
https://doi.org/10.1084/jem.20240365
Published: 17 July 2024
View articletitled, Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies
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Includes: Supplementary data
Journal Articles

A novel STING variant triggers endothelial toxicity and SAVI disease

In Special Collection:
Immunology Update Winter 2025
Erika Valeri, Sara Breggion, Federica Barzaghi, Monah Abou Alezz, Giovanni Crivicich, Isabel Pagani, Federico Forneris, Claudia Sartirana, Matteo Costantini, Stefania Costi, Achille Marino, Eleonora Chiarotto, Davide Colavito, Rolando Cimaz, Ivan Merelli, Elisa Vicenzi, Alessandro Aiuti, Anna Kajaste-Rudnitski
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (9): e20232167.
https://doi.org/10.1084/jem.20232167
Published: 02 July 2024
View articletitled, A novel STING variant triggers endothelial toxicity and SAVI disease
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Includes: Supplementary data
Journal Articles

Traffic on the TLR expressway

Justin Taft, Dusan Bogunovic
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (8): e20240841.
https://doi.org/10.1084/jem.20240841
Published: 13 June 2024
View articletitled, Traffic on the TLR expressway
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