Search Results for CBD

...), the CDN binding domain (CBD) in the middle (required for CDN binding), and the C-terminal tail (CTT) domain at the C terminus (required for TBK1 and IRF3 binding and activation of IFN signaling; see diagrams in Fig. 4 B ). Deletion of TM, CBD, or CTT individually or in combination completely abolished...

.... However, each species encodes different CD-NTases that respond to special microbial challenges and then produce distinct CDNs. Each species also encodes STING with different functional domains in addition to the CDN-binding domain that activate different downstream signaling pathways. CBD, cGAMP-binding...

... samples). (C) Sanger sequencing highlights the de novo occurring mutation in STING1 gene in the SAVI patient and the WT sequence in her parents. (D) STING protein domains with highlighted the de novo mutation causing SAVI disease in the patient (TM = transmembrane domain; DD = dimerization domain; CBD...