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Journal Articles

Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma

Jia Ming Nickolas Teo, Zhulin Chen, Weixin Chen, Rachael Julia Yuenyinn Tan, Qi Cao, Yingming Chu, Delin Ma, Liting Chen, Huajian Yu, Ka-Hei Lam, Terence Kin Wah Lee, Svetoslav Chakarov, Burkhard Becher, Ning Zhang, Zhao Li, Stephanie Ma, Ruidong Xue, Guang Sheng Ling
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241442.
https://doi.org/10.1084/jem.20241442
Published: 05 December 2024
View article titled, Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma
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Includes: Supplementary data
Journal Articles

Human DBR1 deficiency impairs stress granule–dependent PKR antiviral immunity

Shuo Ru, Sisi Tang, Hui Xu, Jiahao Yin, Yan Guo, Liuping Song, Zhenyu Jin, Danyel Lee, Yi-Hao Chan, Xingyao Chen, Luke Buerer, William Fairbrother, Weidong Jia, Jean-Laurent Casanova, Shen-Ying Zhang, Daxing Gao
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240010.
https://doi.org/10.1084/jem.20240010
Published: 05 December 2024
View article titled, Human DBR1 deficiency impairs stress granule–dependent PKR antiviral immunity
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Includes: Supplementary data
Journal Articles

Cindy Ma: Science is often not black and white, and the answer usually lies in the grey

Montserrat Cols
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20242177.
https://doi.org/10.1084/jem.20242177
Published: 05 December 2024
View article titled, Cindy Ma: Science is often not black and white, and the answer usually lies in the grey
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Journal Articles

Kazuyo Moro: Building relationships is essential for gaining both speed and opportunities in research

Montserrat Cols
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20242176.
https://doi.org/10.1084/jem.20242176
Published: 04 December 2024
View article titled, Kazuyo Moro: Building relationships is essential for gaining both speed and opportunities in research
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Journal Articles

Bridging the gap between tumor and disease: Innovating cancer and glioma models

Stefano M. Cirigliano, Howard A. Fine
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20220808.
https://doi.org/10.1084/jem.20220808
Published: 03 December 2024
View article titled, Bridging the gap between tumor and disease: Innovating cancer and glioma models
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Journal Articles

Genetic and environmental risks for clonal hematopoiesis and cancer

Stephanie Franco, Lucy A. Godley
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20230931.
https://doi.org/10.1084/jem.20230931
Published: 03 December 2024
View article titled, Genetic and environmental risks for clonal hematopoiesis and cancer
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Journal Articles

Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis

Arja Ray, Kenneth H. Hu, Kelly Kersten, Tristan Courau, Nicholas F. Kuhn, Itzia Zaleta-Linares, Bushra Samad, Alexis J. Combes, Matthew F. Krummel
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240957.
https://doi.org/10.1084/jem.20240957
Published: 27 November 2024
View article titled, Targeting CD206<sup>+</sup> macrophages disrupts the establishment of a key antitumor immune axis
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Journal Articles

Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile

Tasia D. Kellogg, Simona Ceglia, Benedikt M. Mortzfeld, Tanvi M. Tanna, Abigail L. Zeamer, Matthew R. Mancini, Sage E. Foley, Doyle V. Ward, Shakti K. Bhattarai, Beth A. McCormick, Andrea Reboldi, Vanni Bucci
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20232055.
https://doi.org/10.1084/jem.20232055
Published: 26 November 2024
View article titled, Succinate-producing microbiota drives tuft cell hyperplasia to protect against <em>Clostridioides difficile</em>
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Includes: Supplementary data
Journal Articles

p38α–eIF6–Nsun2 axis promotes ILC3’s rapid response to protect host from intestinal inflammation

Jida Huang, Jing Zhang, Panwei Song, Jiaoyan Huang, Zi Yang, Jiahuai Han, Li Wu, Xiaohuan Guo
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20240624.
https://doi.org/10.1084/jem.20240624
Published: 26 November 2024
View article titled, p38α–eIF6–Nsun2 axis promotes ILC3’s rapid response to protect host from intestinal inflammation
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Includes: Supplementary data
Journal Articles

Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer

Huanhuan Joyce Chen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241581.
https://doi.org/10.1084/jem.20241581
Published: 25 November 2024
View article titled, Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer
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Journal Articles

Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer

Camila Robles-Oteíza, Katherine Hastings, Jungmin Choi, Isabelle Sirois, Arvind Ravi, Francisco Expósito, Fernando de Miguel, James R. Knight, Francesc López-Giráldez, Hyejin Choi, Nicholas D. Socci, Taha Merghoub, Mark Awad, Gad Getz, Justin Gainor, Matthew D. Hellmann, Étienne Caron, Susan M. Kaech, Katerina Politi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20231106.
https://doi.org/10.1084/jem.20231106
Published: 25 November 2024
View article titled, Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer
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Includes: Supplementary data
Journal Articles

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, COVID-19 Human Genetic Effort, DIAMONDS, EUCLIDS, Michael J. Carter, Paul Wellman, Mark Peters, Rebeca Pérez de Diego, Lindsey Ann Edwards, Christopher Chiu, Mahdad Noursadeghi, Alexandre Bolze, Chisato Shimizu, Myrsini Kaforou, Melissa Shea Hamilton, Jethro A. Herberg, Erica G. Schmitt, Agusti Rodriguez-Palmero, Aurora Pujol, Jihoon Kim, Aurélie Cobat, Laurent Abel, Shen-Ying Zhang, Jean-Laurent Casanova, Taco W. Kuijpers, Jane C. Burns, Michael Levin, Adrian C. Hayday, Vanessa Sancho-Shimizu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e920240699.
https://doi.org/10.1084/jem.20240699
Published: 22 November 2024
View article titled, Heterozygous <em>BTNL8</em> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)
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Includes: Supplementary data
Journal Articles

JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL

Shifa Khaja Saleem, Sarah Decker, Sandra Kissel, Marcus Bauer, Dmitry Chernyakov, Daniela Bräuer-Hartmann, Konrad Aumann, Claudia Wickenhauser, Marco Herling, Oleksandra Skorobohatko, Nimitha Mathew, Cornelius Schmidt, Claudius Klein, Marie Follo, Christine Dierks
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20230681.
https://doi.org/10.1084/jem.20230681
Published: 21 November 2024
View article titled, JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL
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Includes: Supplementary data
Journal Articles

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P. Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20231967.
https://doi.org/10.1084/jem.20231967
Published: 21 November 2024
View article titled, Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
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Includes: Supplementary data
Journal Articles

An unconventional purine connection

Fabio Grassi
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20241527.
https://doi.org/10.1084/jem.20241527
Published: 19 November 2024
View article titled, An unconventional purine connection
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Journal Articles

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling

Calvin Xu, Andreas Obers, Minyi Qin, Alice Brandli, Joelyn Wong, Xin Huang, Allison Clatch, Aly Fayed, Graham Starkey, Rohit D’Costa, Claire L. Gordon, Jeffrey Y.W. Mak, David P. Fairlie, Lynette Beattie, Laura K. Mackay, Dale I. Godfrey, Hui-Fern Koay
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240354.
https://doi.org/10.1084/jem.20240354
Published: 19 November 2024
View article titled, Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling
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Journal Articles

Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

Sonia Tejedor Vaquero, Hadas Neuman, Laura Comerma, Xavi Marcos-Fa, Celia Corral-Vazquez, Mathieu Uzzan, Marc Pybus, Daniel Segura-Garzón, Joana Guerra, Lisa Perruzza, Roser Tachó-Piñot, Jordi Sintes, Adam Rosenstein, Emilie K. Grasset, Mar Iglesias, Monica Gonzalez Farré, Joan Lop, Maria Evangelina Patriaca-Amiano, Monica Larrubia-Loring, Pablo Santiago-Diaz, Júlia Perera-Bel, Pau Berenguer-Molins, Monica Martinez Gallo, Andrea Martin-Nalda, Encarna Varela, Marta Garrido-Pontnou, Fabio Grassi, Francisco Guarner, Saurabh Mehandru, Lucia Márquez-Mosquera, Ramit Mehr, Andrea Cerutti, Giuliana Magri
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20230079.
https://doi.org/10.1084/jem.20230079
Published: 19 November 2024
View article titled, Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease
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Includes: Supplementary data
Journal Articles

Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency

Elena Blanco, Carme Camps, Sameer Bahal, Mohit D. Kerai, Matteo P. Ferla, Adam M. Rochussen, Adam E. Handel, Zainab M. Golwala, Helena Spiridou Goncalves, Susanne Kricke, Fabian Klein, Fang Zhang, Federica Zinghirino, Grace Evans, Thomas M. Keane, Sabrina Lizot, Maaike A.A. Kusters, Mildred A. Iro, Sanjay V. Patel, Emma C. Morris, Siobhan O. Burns, Ruth Radcliffe, Pradeep Vasudevan, Arthur Price, Olivia Gillham, Gabriel E. Valdebenito, Grant S. Stewart, Austen Worth, Stuart P. Adams, Michael Duchen, Isabelle André, David J. Adams, Giorgia Santili, Kimberly C. Gilmour, Georg A. Holländer, E. Graham Davies, Jenny C. Taylor, Gillian M. Griffiths, Adrian J. Thrasher, Fatima Dhalla, Alexandra Y. Kreins
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20220979.
https://doi.org/10.1084/jem.20220979
Published: 19 November 2024
View article titled, Dominant negative variants in <em>ITPR3</em> impair T cell Ca<sup>2+</sup> dynamics causing combined immunodeficiency
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Includes: Supplementary data
Journal Articles

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Xue Li, Han Yi, Zheyu Jin, Kaitao Jiang, Kangkang Xue, Jin Wang, Yuping Qian, Qian Xiang, Sijing Zhu, Runhe Yan, Yulong Yang, Shenfei Sun, Kai Li, Zichu Zhou, Wei Yu, Ning Jiang, Chen Ding, Xinhua Lin, Jiang Zhong, Yuchao Dong, Yanfang Liu, Xiaofei Yu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240959.
https://doi.org/10.1084/jem.20240959
Published: 15 November 2024
View article titled, MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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Includes: Supplementary data
Journal Articles

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA

Eric Yixiao Cao, Kyle Burrows, Pailin Chiaranunt, Ana Popovic, Xueyang Zhou, Cong Xie, Ayushi Thakur, Graham Britton, Matthew Spindler, Louis Ngai, Siu Ling Tai, Dragos Cristian Dasoveanu, Albert Nguyen, Jeremiah J. Faith, John Parkinson, Jennifer L. Gommerman, Arthur Mortha
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20221727.
https://doi.org/10.1084/jem.20221727
Published: 13 November 2024
View article titled, The protozoan commensal <em>Tritrichomonas musculis</em> is a natural adjuvant for mucosal IgA
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Includes: Supplementary data