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Journal Articles

Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

J Exp Med (2025) 222 (7): e20232357.

https://doi.org/10.1084/jem.20232357

Published: 23 April 2025

View articletitled, Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Includes: Supplementary data

Journal Articles

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

In Special Collection:

JEM Clinical Immunology Collection 2025

Seth D. Fortmann, Blake F. Frey, Robert F. Rosencrans, Yvonne Adu-Rutledge, Edgar Ready V, Kameron V. Kilchrist, Robert S. Welner, Michael E. Boulton, Daniel R. Saban, Maria B. Grant

J Exp Med (2025) 222 (7): e20242007.

https://doi.org/10.1084/jem.20242007

Published: 22 April 2025

View articletitled, Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Includes: Supplementary data

Journal Articles

Oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity

Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler

J Exp Med (2025) 222 (7): e20241188.

https://doi.org/10.1084/jem.20241188

Published: 14 April 2025

View articletitled, Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

Includes: Supplementary data

Journal Articles

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Zhangying Cai, Shoutang Wang, Siyan Cao, Yun Chen, Silvia Penati, Vincent Peng, Carla M. Yuede, Wandy L. Beatty, Kent Lin, Yiyang Zhu, Yingyue Zhou, Marco Colonna

J Exp Med (2025) 222 (4): e20230173.

https://doi.org/10.1084/jem.20230173

Published: 13 February 2025

View articletitled, Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Includes: Supplementary data

Journal Articles

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

In Special Collection:

JEM Immunology Collection 2025

Zachary Papadopoulos, Leon C.D. Smyth, Igor Smirnov, Daniel A. Gibson, Jasmin Herz, Jonathan Kipnis

J Exp Med (2025) 222 (2): e20241752.

https://doi.org/10.1084/jem.20241752

Published: 08 January 2025

View articletitled, Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

Journal Articles

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S. Prado, Richard T. Cattley, Andreza B. Sonego, Parth Sutariya, Shuxian Wu, Mijoon Lee, William C. Boggess, Mark J. Shlomchik, William F. Hawse

J Exp Med (2024) 222 (2): e20240625.

https://doi.org/10.1084/jem.20240625

Published: 31 December 2024

View articletitled, The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Includes: Supplementary data

Journal Articles

Dual role of vascular endothelial growth factor-C in post-stroke recovery

Yun Hwa Choi, Martin Hsu, Collin Laaker, Jenna Port, Kristóf G. Kovács, Melinda Herbath, Heeyoon Yang, Peter Cismaru, Alexis M. Johnson, Bailey Spellman, Kelsey Wigand, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2024) 222 (2): e20231816.

https://doi.org/10.1084/jem.20231816

Published: 12 December 2024

View articletitled, Dual role of vascular endothelial growth factor-C in post-stroke recovery

Includes: Supplementary data

Journal Articles

Antiviral immunity lassoed down by excess RNA

Erika Valeri, Anna Kajaste-Rudnitski

J Exp Med (2024) 222 (1): e20241743.

https://doi.org/10.1084/jem.20241743

Published: 06 December 2024

View articletitled, Antiviral immunity lassoed down by excess RNA

Journal Articles

Immune drivers of physiological and pathological pain

In Special Collection:

JEM Clinical Immunology Collection 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024

Aakanksha Jain, Sara Hakim, Clifford J. Woolf

J Exp Med (2024) 221 (5): e20221687.

https://doi.org/10.1084/jem.20221687

Published: 12 April 2024

View articletitled, Immune drivers of physiological and pathological pain

Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:

JEM Cancer Collection 2024 , Neuroscience Collection 2024

Morgan E. Freret, Adrienne Boire

J Exp Med (2024) 221 (4): e20212121.

https://doi.org/10.1084/jem.20212121

Published: 07 March 2024

View articletitled, The anatomic basis of leptomeningeal metastasis

Journal Articles

Meningeal lymphatics can influence stroke outcome

Gou Young Koh, Donald M. McDonald

J Exp Med (2024) 221 (4): e20232305.

https://doi.org/10.1084/jem.20232305

Published: 05 March 2024

View articletitled, Meningeal lymphatics can influence stroke outcome

Journal Articles

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

In Special Collection:

Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine

J Exp Med (2024) 221 (4): e20221983.

https://doi.org/10.1084/jem.20221983

Published: 05 March 2024

View articletitled, VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

Includes: Supplementary data

Journal Articles

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

In Special Collection:

JEM Immunology Collection 2024 , Immunometabolism 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , Immunology Update Winter 2025

Danira Toral-Rios, Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland, Xianlin Han, David M. Holtzman, Anil G. Cashikar, Steven M. Paul

J Exp Med (2024) 221 (4): e20232000.

https://doi.org/10.1084/jem.20232000

Published: 01 March 2024

View articletitled, Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Includes: Supplementary data

Journal Articles

TCR signaling induces STAT3 phosphorylation to promote T_H17 cell differentiation

In Special Collection:

Autoimmunity 2024

Zhen Qin, Ruining Wang, Ping Hou, Yuanyuan Zhang, Qianmu Yuan, Ying Wang, Yuedong Yang, Tao Xu

J Exp Med (2024) 221 (3): e20230683.

https://doi.org/10.1084/jem.20230683

Published: 07 February 2024

View articletitled, TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation

Includes: Supplementary data

Journal Articles

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2

In Special Collection:

Neuroimmunology and Neurodegeneration 2024 , Immunology Update Winter 2025

Chen Yu, Eleonora M. Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jinchao Hou, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D. Proia, Marco Colonna, Christian Haass, Daniel R. Saban

J Exp Med (2024) 221 (3): e20231011.

https://doi.org/10.1084/jem.20231011

Published: 30 January 2024

View articletitled, Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2

Includes: Supplementary data

Journal Articles

Dural mural cells paint an anti-inflammatory picture

Nicole C. Lummis, Benjamin D. Gastfriend, Richard Daneman

J Exp Med (2024) 221 (2): e20232263.

https://doi.org/10.1084/jem.20232263

Published: 25 January 2024

View articletitled, Dural mural cells paint an anti-inflammatory picture

Journal Articles

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

In Special Collection:

Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine

Mika P. Cadiz, Katelin A. Gibson, Kennedi T. Todd, David G. Nascari, Nashali Massa, Meredith T. Lilley, Kimberly C. Olney, Md Mamun Al-Amin, Hong Jiang, David M. Holtzman, John D. Fryer

J Exp Med (2024) 221 (2): e20231363.

https://doi.org/10.1084/jem.20231363

Published: 16 January 2024

View articletitled, Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

Includes: Supplementary data

Journal Articles

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

In Special Collection:

Autoimmunity 2024 , Lymphatic Vessels in Health and Disease 2024 , Neuroscience Collection 2024

Hyunjung Min, Shane M. O’Neil, Li Xu, E. Ashley Moseman, Joanne Kurtzberg, Anthony J. Filiano

J Exp Med (2024) 221 (2): e20230326.

https://doi.org/10.1084/jem.20230326

Published: 09 January 2024

View articletitled, Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

Includes: Supplementary data

Journal Articles

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4⁺ T cells during inflammation

In Special Collection:

Barrier Immunity , Autoimmunity 2024 , Immunometabolism 2024

J Exp Med (2024) 221 (2): e20230449.

https://doi.org/10.1084/jem.20230449

Published: 08 January 2024

View articletitled, Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation

Includes: Supplementary data

Journal Articles

CD163⁺ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

In Special Collection:

Barrier Immunity , Immunology Update Winter 2024

J Exp Med (2023) 221 (2): e20230675.

https://doi.org/10.1084/jem.20230675

Published: 20 December 2023

View articletitled, CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

Includes: Supplementary data

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Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Dual role of vascular endothelial growth factor-C in post-stroke recovery

Antiviral immunity lassoed down by excess RNA

Immune drivers of physiological and pathological pain

The anatomic basis of leptomeningeal metastasis

Meningeal lymphatics can influence stroke outcome

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

TCR signaling induces STAT3 phosphorylation to promote T_H17 cell differentiation

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2

Dural mural cells paint an anti-inflammatory picture

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4⁺ T cells during inflammation

CD163⁺ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

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