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Journal Articles

The cribriform plate: A dynamic central nervous system–immune hub

Collin J. Laaker, Sophia M. Vrba, Jenna M. Port, Martin Hsu, Cameron M. Baenen, Melinda Herbath, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2025) 223 (2): e20251871.

https://doi.org/10.1084/jem.20251871

Published: 30 December 2025

View article titled, The cribriform plate: A dynamic central nervous system–immune hub

Journal Articles

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease

J Exp Med (2025) 223 (2): e20251860.

https://doi.org/10.1084/jem.20251860

Published: 02 December 2025

View article titled, Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease

Includes: Supplementary data

Journal Articles

Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

In Special Collection:

Neuroscience Collection 2025

Alexandra Florescu, Michelle Zuo, Angela A. Wang, Kevin Champagne-Jorgensen, Mohammed A. Noor, Lesley A. Ward, Erwin van Puijenbroek, Christian Klein, Jennifer L. Gommerman

J Exp Med (2025) 222 (12): e20241255.

https://doi.org/10.1084/jem.20241255

Published: 18 September 2025

View article titled, Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

Includes: Supplementary data

Journal Articles

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

In Special Collection:

Neuroscience Collection 2025

Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze

J Exp Med (2025) 222 (10): e20250965.

https://doi.org/10.1084/jem.20250965

Published: 26 August 2025

View article titled, ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Journal Articles

Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

In Special Collection:

Neuroscience Collection 2025

An Ping, Fan Yang, Lingxiao Lu, Xiaotao Zhang, Jianan Lu, Huaming Li, Yichen Gu, Ziyang Jin, Jianmin Zhang, Ligen Shi

J Exp Med (2025) 222 (11): e20241830.

https://doi.org/10.1084/jem.20241830

Published: 25 August 2025

View article titled, Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

Journal Articles

Antibiotics unleash neuroinflammation

Jessica E. Kenison, Francisco J. Quintana

J Exp Med (2025) 222 (9): e20251233.

https://doi.org/10.1084/jem.20251233

Published: 19 August 2025

View article titled, Antibiotics unleash neuroinflammation

Journal Articles

Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

In Special Collection:

Neuroscience Collection 2025 , Neuroimmunology and Neurodegeneration 2025

J Exp Med (2025) 222 (7): e20232357.

https://doi.org/10.1084/jem.20232357

Published: 23 April 2025

View article titled, Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Includes: Supplementary data

Journal Articles

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

In Special Collection:

JEM Clinical Immunology Collection 2025 , Macrophages and Dendritic Cells in Health and Disease , Neuroimmunology and Neurodegeneration 2025

Seth D. Fortmann, Blake F. Frey, Robert F. Rosencrans, Yvonne Adu-Rutledge, Edgar Ready V, Kameron V. Kilchrist, Robert S. Welner, Michael E. Boulton, Daniel R. Saban, Maria B. Grant

J Exp Med (2025) 222 (7): e20242007.

https://doi.org/10.1084/jem.20242007

Published: 22 April 2025

View article titled, Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Includes: Supplementary data

Journal Articles

Oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity

In Special Collection:

Neuroimmunology and Neurodegeneration 2025

Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler

J Exp Med (2025) 222 (7): e20241188.

https://doi.org/10.1084/jem.20241188

Published: 14 April 2025

View article titled, Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

Includes: Supplementary data

Journal Articles

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

In Special Collection:

Neuroimmunology and Neurodegeneration 2025

Zhangying Cai, Shoutang Wang, Siyan Cao, Yun Chen, Silvia Penati, Vincent Peng, Carla M. Yuede, Wandy L. Beatty, Kent Lin, Yiyang Zhu, Yingyue Zhou, Marco Colonna

J Exp Med (2025) 222 (4): e20230173.

https://doi.org/10.1084/jem.20230173

Published: 13 February 2025

View article titled, Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Includes: Supplementary data

Journal Articles

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

In Special Collection:

JEM Immunology Collection 2025 , Neuroscience Collection 2025

Zachary Papadopoulos, Leon C.D. Smyth, Igor Smirnov, Daniel A. Gibson, Jasmin Herz, Jonathan Kipnis

J Exp Med (2025) 222 (2): e20241752.

https://doi.org/10.1084/jem.20241752

Published: 08 January 2025

View article titled, Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

Journal Articles

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S. Prado, Richard T. Cattley, Andreza B. Sonego, Parth Sutariya, Shuxian Wu, Mijoon Lee, William C. Boggess, Mark J. Shlomchik, William F. Hawse

J Exp Med (2024) 222 (2): e20240625.

https://doi.org/10.1084/jem.20240625

Published: 31 December 2024

View article titled, The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Includes: Supplementary data

Journal Articles

Dual role of vascular endothelial growth factor-C in post-stroke recovery

In Special Collection:

Neuroimmunology and Neurodegeneration 2025

Yun Hwa Choi, Martin Hsu, Collin Laaker, Jenna Port, Kristóf G. Kovács, Melinda Herbath, Heeyoon Yang, Peter Cismaru, Alexis M. Johnson, Bailey Spellman, Kelsey Wigand, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2024) 222 (2): e20231816.

https://doi.org/10.1084/jem.20231816

Published: 12 December 2024

View article titled, Dual role of vascular endothelial growth factor-C in post-stroke recovery

Includes: Supplementary data

Journal Articles

Antiviral immunity lassoed down by excess RNA

Erika Valeri, Anna Kajaste-Rudnitski

J Exp Med (2024) 222 (1): e20241743.

https://doi.org/10.1084/jem.20241743

Published: 06 December 2024

View article titled, Antiviral immunity lassoed down by excess RNA

Journal Articles

Immune drivers of physiological and pathological pain

In Special Collection:

JEM Clinical Immunology Collection 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024

Aakanksha Jain, Sara Hakim, Clifford J. Woolf

J Exp Med (2024) 221 (5): e20221687.

https://doi.org/10.1084/jem.20221687

Published: 12 April 2024

View article titled, Immune drivers of physiological and pathological pain

Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:

JEM Cancer Collection 2024 , Neuroscience Collection 2024

Morgan E. Freret, Adrienne Boire

J Exp Med (2024) 221 (4): e20212121.

https://doi.org/10.1084/jem.20212121

Published: 07 March 2024

View article titled, The anatomic basis of leptomeningeal metastasis

Journal Articles

Meningeal lymphatics can influence stroke outcome

Gou Young Koh, Donald M. McDonald

J Exp Med (2024) 221 (4): e20232305.

https://doi.org/10.1084/jem.20232305

Published: 05 March 2024

View article titled, Meningeal lymphatics can influence stroke outcome

Journal Articles

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

In Special Collection:

Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine

J Exp Med (2024) 221 (4): e20221983.

https://doi.org/10.1084/jem.20221983

Published: 05 March 2024

View article titled, VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

Includes: Supplementary data

Journal Articles

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

In Special Collection:

JEM Immunology Collection 2024 , Immunometabolism 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , Immunology Update Winter 2025

Danira Toral-Rios, Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland, Xianlin Han, David M. Holtzman, Anil G. Cashikar, Steven M. Paul

J Exp Med (2024) 221 (4): e20232000.

https://doi.org/10.1084/jem.20232000

Published: 01 March 2024

View article titled, Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Includes: Supplementary data

Journal Articles

TCR signaling induces STAT3 phosphorylation to promote T_H17 cell differentiation

In Special Collection:

Autoimmunity 2024

Zhen Qin, Ruining Wang, Ping Hou, Yuanyuan Zhang, Qianmu Yuan, Ying Wang, Yuedong Yang, Tao Xu

J Exp Med (2024) 221 (3): e20230683.

https://doi.org/10.1084/jem.20230683

Published: 07 February 2024

View article titled, TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation

Includes: Supplementary data

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The cribriform plate: A dynamic central nervous system–immune hub

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease

Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

Antibiotics unleash neuroinflammation

Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Dual role of vascular endothelial growth factor-C in post-stroke recovery

Antiviral immunity lassoed down by excess RNA

Immune drivers of physiological and pathological pain

The anatomic basis of leptomeningeal metastasis

Meningeal lymphatics can influence stroke outcome

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

TCR signaling induces STAT3 phosphorylation to promote T_H17 cell differentiation

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