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Journal Articles

Immune drivers of physiological and pathological pain

In Special Collection:
JEM Clinical Immunology Collection 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Aakanksha Jain, Sara Hakim, Clifford J. Woolf
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20221687.
https://doi.org/10.1084/jem.20221687
Published: 12 April 2024
View article titled, Immune drivers of physiological and pathological pain
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Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:
JEM Cancer Collection 2024 , Neuroscience Collection 2024
Morgan E. Freret, Adrienne Boire
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (4): e20212121.
https://doi.org/10.1084/jem.20212121
Published: 07 March 2024
View article titled, The anatomic basis of leptomeningeal metastasis
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Journal Articles

Meningeal lymphatics can influence stroke outcome

Gou Young Koh, Donald M. McDonald
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20232305.
https://doi.org/10.1084/jem.20232305
Published: 05 March 2024
View article titled, Meningeal lymphatics can influence stroke outcome
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Journal Articles

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Ligia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee, Basavaraju G. Sanganahalli, Myriam Spajer, Shenqi Zhang, Sungwoon Lee, Maxime Parent, Yuechuan Xue, Mario Skarica, Xiangyun Yin, Justine Guegan, Kevin Boyé, Felipe Saceanu Leser, Laurent Jacob, Mathilde Poulet, Mingfeng Li, Xiodan Liu, Sofia E. Velazquez, Ruchith Singhabahu, Mark E. Robinson, Michael H. Askenase, Artem Osherov, Nenad Sestan, Jiangbing Zhou, Kari Alitalo, Eric Song, Anne Eichmann, Lauren H. Sansing, Helene Benveniste, Fahmeed Hyder, Jean-Leon Thomas
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221983.
https://doi.org/10.1084/jem.20221983
Published: 05 March 2024
View article titled, VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
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Includes: Supplementary data
Journal Articles

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

In Special Collection:
JEM Immunology Collection 2024 , Immunometabolism 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Danira Toral-Rios, Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland, Xianlin Han, David M. Holtzman, Anil G. Cashikar, Steven M. Paul
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20232000.
https://doi.org/10.1084/jem.20232000
Published: 01 March 2024
View article titled, Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy
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Includes: Supplementary data
Journal Articles

TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation

In Special Collection:
Autoimmunity 2024
Zhen Qin, Ruining Wang, Ping Hou, Yuanyuan Zhang, Qianmu Yuan, Ying Wang, Yuedong Yang, Tao Xu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (3): e20230683.
https://doi.org/10.1084/jem.20230683
Published: 07 February 2024
View article titled, TCR signaling induces STAT3 phosphorylation to promote T<sub>H</sub>17 cell differentiation
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Includes: Supplementary data
Journal Articles

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2

In Special Collection:
Neuroimmunology and Neurodegeneration 2024
Chen Yu, Eleonora M. Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jinchao Hou, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D. Proia, Marco Colonna, Christian Haass, Daniel R. Saban
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (3): e20231011.
https://doi.org/10.1084/jem.20231011
Published: 30 January 2024
View article titled, Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2
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Includes: Supplementary data
Journal Articles

Dural mural cells paint an anti-inflammatory picture

Nicole C. Lummis, Benjamin D. Gastfriend, Richard Daneman
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20232263.
https://doi.org/10.1084/jem.20232263
Published: 25 January 2024
View article titled, Dural mural cells paint an anti-inflammatory picture
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Journal Articles

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Mika P. Cadiz, Katelin A. Gibson, Kennedi T. Todd, David G. Nascari, Nashali Massa, Meredith T. Lilley, Kimberly C. Olney, Md Mamun Al-Amin, Hong Jiang, David M. Holtzman, John D. Fryer
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20231363.
https://doi.org/10.1084/jem.20231363
Published: 16 January 2024
View article titled, Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations
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Includes: Supplementary data
Journal Articles

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

In Special Collection:
Autoimmunity 2024 , Lymphatic Vessels in Health and Disease 2024 , Neuroscience Collection 2024
Hyunjung Min, Shane M. O’Neil, Li Xu, E. Ashley Moseman, Joanne Kurtzberg, Anthony J. Filiano
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20230326.
https://doi.org/10.1084/jem.20230326
Published: 09 January 2024
View article titled, Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance
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Includes: Supplementary data
Journal Articles

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation

In Special Collection:
Barrier Immunity , Autoimmunity 2024 , Immunometabolism 2024
Emeline Joulia, Michaël F. Michieletto, Arantxa Agesta, Cindy Peillex, Virginie Girault, Anne-Louise Le Dorze, Romain Peroceschi, Florence Bucciarelli, Marion Szelechowski, Adeline Chaubet, Nawad Hakim, Rémi Marrocco, Emeline Lhuillier, Manuel Lebeurrier, Rafael J. Argüello, Abdelhadi Saoudi, Hicham El Costa, Veronique Adoue, Thierry Walzer, Jean-Emmanuel Sarry, Anne S. Dejean
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20230449.
https://doi.org/10.1084/jem.20230449
Published: 08 January 2024
View article titled, Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4<sup>+</sup> T cells during inflammation
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Includes: Supplementary data
Journal Articles

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

In Special Collection:
Barrier Immunity , Immunology Update Winter 2024
Harald Lund, Matthew A. Hunt, Zerina Kurtović, Katalin Sandor, Paul B. Kägy, Noah Fereydouni, Anais Julien, Christian Göritz, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Alexandra Jurczak, Jinming Han, Keying Zhu, Robert A. Harris, Jon Lampa, Jonas Heilskov Graversen, Anders Etzerodt, Lisbet Haglund, Tony L. Yaksh, Camilla I. Svensson
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (2): e20230675.
https://doi.org/10.1084/jem.20230675
Published: 20 December 2023
View article titled, CD163<sup>+</sup> macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
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Includes: Supplementary data
Journal Articles

ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Jung Hwa Lim, Hyun Mi Kang, Dae Hun Kim, Bohyeon Jeong, Da Yong Lee, Jae-Ran Lee, Jeong Yeob Baek, Hyun-Soo Cho, Mi-Young Son, Dae Soo Kim, Nam-Soon Kim, Cho-Rok Jung
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230367.
https://doi.org/10.1084/jem.20230367
Published: 07 November 2023
View article titled, <em>ARL6IP1</em> gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model
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Includes: Supplementary data
Journal Articles

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation

In Special Collection:
Neuroscience Collection 2023
William T. Ralvenius, Alison E. Mungenast, Hannah Woolf, Margaret M. Huston, Tyler Z. Gillingham, Stephen K. Godin, Jay Penney, Hugh P. Cam, Fan Gao, Celia G. Fernandez, Barbara Czako, Yaima Lightfoot, William J. Ray, Adrian Beckmann, Alison M. Goate, Edoardo Marcora, Carmen Romero-Molina, Pinar Ayata, Anne Schaefer, Elizabeta Gjoneska, Li-Huei Tsai
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (11): e20222105.
https://doi.org/10.1084/jem.20222105
Published: 29 August 2023
View article titled, A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation
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Includes: Supplementary data
Journal Articles

CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy

In Special Collection:
Neuroscience Collection 2023
Pearl A. Sutter, Antoine Ménoret, Evan R. Jellison, Alexandra M. Nicaise, Allison M. Bradbury, Anthony T. Vella, Ernesto R. Bongarzone, Stephen J. Crocker
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (9): e20221862.
https://doi.org/10.1084/jem.20221862
Published: 13 June 2023
View article titled, CD8<sup>+</sup> T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy
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Includes: Supplementary data
Journal Articles

Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage

In Special Collection:
Lymphatic Vessels in Health and Disease 2024 , Neuroscience Collection 2023 , Neuroimmunology and Neurodegeneration 2023
Justin Rustenhoven, Georgios Pavlou, Steffen E. Storck, Taitea Dykstra, Siling Du, Zhengpeng Wan, Daniel Quintero, Joshua P. Scallan, Igor Smirnov, Roger D. Kamm, Jonathan Kipnis
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (7): e20221929.
https://doi.org/10.1084/jem.20221929
Published: 07 April 2023
View article titled, Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage
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Journal Articles

Engineering mighty microglia

Adeline E. Walsh, John R. Lukens
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (3): e20222070.
https://doi.org/10.1084/jem.20222070
Published: 17 January 2023
View article titled, Engineering mighty microglia
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Journal Articles

Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

In Special Collection:
JEM Clinical Immunology Collection 2023 , Neuroimmunology and Neurodegeneration 2023 , 2023: The Year in Experimental Medicine
Jean Paul Chadarevian, Sonia I. Lombroso, Graham C. Peet, Jonathan Hasselmann, Christina Tu, Dave E. Marzan, Joia Capocchi, Freddy S. Purnell, Kelsey M. Nemec, Alina Lahian, Adrian Escobar, Whitney England, Sai Chaluvadi, Carleigh A. O’Brien, Fazeela Yaqoob, William H. Aisenberg, Matias Porras-Paniagua, Mariko L. Bennett, Hayk Davtyan, Robert C. Spitale, Mathew Blurton-Jones, F. Chris Bennett
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (3): e20220857.
https://doi.org/10.1084/jem.20220857
Published: 30 December 2022
View article titled, Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
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Includes: Supplementary data
Journal Articles

Targeting neuroinflammation in neuropathic pain and opioid use

In Special Collection:
Neuroscience Collection 2023 , Neuroimmunology and Neurodegeneration 2023
Daniela Salvemini, Timothy M. Doyle
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20221244.
https://doi.org/10.1084/jem.20221244
Published: 23 December 2022
View article titled, Targeting neuroinflammation in neuropathic pain and opioid use
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Journal Articles

Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice

In Special Collection:
Neuroimmunology and Neurodegeneration 2023
Rafael T. Han, Ilia D. Vainchtein, Johannes C.M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. Barron, Hiromi Nakao-Inoue, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna V. Molofsky
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20220605.
https://doi.org/10.1084/jem.20220605
Published: 15 December 2022
View article titled, Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice
Open the PDF for Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice in another window
Includes: Supplementary data