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Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6C^highLy6G^low monocytes after stroke

Weijie Chen, Xin Wang, Tingting Huang, Yan Li, Chen Chen, Yueman Zhang, Wanqing Xie, Dan Tang, Qiuyue Fan, Rui Pang, Jiemin Yin, Tim Sparwasser, Zhenghong Wang, Arthur Liesz, Yu Gan, Weifeng Yu, Florent Ginhoux, Peiying Li

J Exp Med (2026) 223 (4): e20242025.

https://doi.org/10.1084/jem.20242025

Published: 18 March 2026

View article titled, Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke

Includes: Supplementary data

Journal Articles

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

J Exp Med (2026) 223 (4): e20251761.

https://doi.org/10.1084/jem.20251761

Published: 03 March 2026

View article titled, Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

Includes: Supplementary data

Journal Articles

NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Nishada S. Ramphal, Xinyuan Liu, Ilaria Palagi, Rebecca Jasser, Alma N. Mohebiany, Matthias Klein, Frederike Westermann, Sinduya Krishnarajah, Tommy Regen, Tobias Bopp, Burkhard Becher, Ari Waisman

J Exp Med (2026) 223 (4): e20242294.

https://doi.org/10.1084/jem.20242294

Published: 27 February 2026

View article titled, NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Includes: Supplementary data

Journal Articles

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation

Okito Hashimoto, Tyler D. Hepler, Aisling Tynan, Alejandro Torres, Jian Hua Li, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan

J Exp Med (2026) 223 (4): e20252000.

https://doi.org/10.1084/jem.20252000

Published: 26 February 2026

View article titled, Central neurons encode interleukin-1β signals and mediate stress-induced inflammation

Journal Articles

The cribriform plate: A dynamic central nervous system–immune hub

In Special Collection:

Immunology Update Winter 2026 , Lymphatic Vessels in Health and Disease 2026

Collin J. Laaker, Sophia M. Vrba, Jenna M. Port, Martin Hsu, Cameron M. Baenen, Melinda Herbath, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2025) 223 (2): e20251871.

https://doi.org/10.1084/jem.20251871

Published: 30 December 2025

View article titled, The cribriform plate: A dynamic central nervous system–immune hub

Journal Articles

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease

In Special Collection:

Lymphatic Vessels in Health and Disease 2026

J Exp Med (2025) 223 (2): e20251860.

https://doi.org/10.1084/jem.20251860

Published: 02 December 2025

View article titled, Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease

Includes: Supplementary data

Journal Articles

Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

In Special Collection:

Neuroscience Collection 2025 , Immunology Update Winter 2026

Alexandra Florescu, Michelle Zuo, Angela A. Wang, Kevin Champagne-Jorgensen, Mohammed A. Noor, Lesley A. Ward, Erwin van Puijenbroek, Christian Klein, Jennifer L. Gommerman

J Exp Med (2025) 222 (12): e20241255.

https://doi.org/10.1084/jem.20241255

Published: 18 September 2025

View article titled, Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

Includes: Supplementary data

Journal Articles

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

In Special Collection:

Neuroscience Collection 2025

Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze

J Exp Med (2025) 222 (10): e20250965.

https://doi.org/10.1084/jem.20250965

Published: 26 August 2025

View article titled, ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Journal Articles

Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

In Special Collection:

Neuroscience Collection 2025

An Ping, Fan Yang, Lingxiao Lu, Xiaotao Zhang, Jianan Lu, Huaming Li, Yichen Gu, Ziyang Jin, Jianmin Zhang, Ligen Shi

J Exp Med (2025) 222 (11): e20241830.

https://doi.org/10.1084/jem.20241830

Published: 25 August 2025

View article titled, Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

Journal Articles

Antibiotics unleash neuroinflammation

Jessica E. Kenison, Francisco J. Quintana

J Exp Med (2025) 222 (9): e20251233.

https://doi.org/10.1084/jem.20251233

Published: 19 August 2025

View article titled, Antibiotics unleash neuroinflammation

Journal Articles

Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

In Special Collection:

Neuroimmunology and Neurodegeneration 2025 , Neuroscience Collection 2025

J Exp Med (2025) 222 (7): e20232357.

https://doi.org/10.1084/jem.20232357

Published: 23 April 2025

View article titled, Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Includes: Supplementary data

Journal Articles

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

In Special Collection:

JEM Clinical Immunology Collection 2025 , Neuroimmunology and Neurodegeneration 2025 , Macrophages and Dendritic Cells in Health and Disease

Seth D. Fortmann, Blake F. Frey, Robert F. Rosencrans, Yvonne Adu-Rutledge, Edgar Ready V, Kameron V. Kilchrist, Robert S. Welner, Michael E. Boulton, Daniel R. Saban, Maria B. Grant

J Exp Med (2025) 222 (7): e20242007.

https://doi.org/10.1084/jem.20242007

Published: 22 April 2025

View article titled, Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Includes: Supplementary data

Journal Articles

Oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity

In Special Collection:

Neuroimmunology and Neurodegeneration 2025

Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler

J Exp Med (2025) 222 (7): e20241188.

https://doi.org/10.1084/jem.20241188

Published: 14 April 2025

View article titled, Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

Includes: Supplementary data

Journal Articles

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

In Special Collection:

Neuroimmunology and Neurodegeneration 2025

Zhangying Cai, Shoutang Wang, Siyan Cao, Yun Chen, Silvia Penati, Vincent Peng, Carla M. Yuede, Wandy L. Beatty, Kent Lin, Yiyang Zhu, Yingyue Zhou, Marco Colonna

J Exp Med (2025) 222 (4): e20230173.

https://doi.org/10.1084/jem.20230173

Published: 13 February 2025

View article titled, Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Includes: Supplementary data

Journal Articles

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

In Special Collection:

JEM Immunology Collection 2025 , Neuroscience Collection 2025

Zachary Papadopoulos, Leon C.D. Smyth, Igor Smirnov, Daniel A. Gibson, Jasmin Herz, Jonathan Kipnis

J Exp Med (2025) 222 (2): e20241752.

https://doi.org/10.1084/jem.20241752

Published: 08 January 2025

View article titled, Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

Journal Articles

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S. Prado, Richard T. Cattley, Andreza B. Sonego, Parth Sutariya, Shuxian Wu, Mijoon Lee, William C. Boggess, Mark J. Shlomchik, William F. Hawse

J Exp Med (2024) 222 (2): e20240625.

https://doi.org/10.1084/jem.20240625

Published: 31 December 2024

View article titled, The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Includes: Supplementary data

Journal Articles

Dual role of vascular endothelial growth factor-C in post-stroke recovery

In Special Collection:

Neuroimmunology and Neurodegeneration 2025

Yun Hwa Choi, Martin Hsu, Collin Laaker, Jenna Port, Kristóf G. Kovács, Melinda Herbath, Heeyoon Yang, Peter Cismaru, Alexis M. Johnson, Bailey Spellman, Kelsey Wigand, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2024) 222 (2): e20231816.

https://doi.org/10.1084/jem.20231816

Published: 12 December 2024

View article titled, Dual role of vascular endothelial growth factor-C in post-stroke recovery

Includes: Supplementary data

Journal Articles

Antiviral immunity lassoed down by excess RNA

Erika Valeri, Anna Kajaste-Rudnitski

J Exp Med (2024) 222 (1): e20241743.

https://doi.org/10.1084/jem.20241743

Published: 06 December 2024

View article titled, Antiviral immunity lassoed down by excess RNA

Journal Articles

Immune drivers of physiological and pathological pain

In Special Collection:

Neuroimmunology and Neurodegeneration 2024 , JEM Clinical Immunology Collection 2024 , Neuroscience Collection 2024

Aakanksha Jain, Sara Hakim, Clifford J. Woolf

J Exp Med (2024) 221 (5): e20221687.

https://doi.org/10.1084/jem.20221687

Published: 12 April 2024

View article titled, Immune drivers of physiological and pathological pain

Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:

JEM Cancer Collection 2024 , Neuroscience Collection 2024

Morgan E. Freret, Adrienne Boire

J Exp Med (2024) 221 (4): e20212121.

https://doi.org/10.1084/jem.20212121

Published: 07 March 2024

View article titled, The anatomic basis of leptomeningeal metastasis

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Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6C^highLy6G^low monocytes after stroke

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment

NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation

The cribriform plate: A dynamic central nervous system–immune hub

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease

Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production

Antibiotics unleash neuroinflammation

Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

Oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Dual role of vascular endothelial growth factor-C in post-stroke recovery

Antiviral immunity lassoed down by excess RNA

Immune drivers of physiological and pathological pain

The anatomic basis of leptomeningeal metastasis

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