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Journal Articles

Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin

Aline Bauer, Lito Zambounis, Ioannis Kritikos, Almut Lütge, Amélie Sabine, Coraline Heron, Milena Petkova, Costanza Giampietro, Katharina Blatter, Salvatore Daniele Bianco, Daniel Gschwend, Gaetana Restivo, Steven T. Proulx, Mitchell P. Levesque, Nicole Lindenblatt, Edoardo Mazza, Michael Detmar, Epameinondas Gousopoulos, Mark D. Robinson, Tatiana V. Petrova, Cornelia Halin
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20242353.
https://doi.org/10.1084/jem.20242353
Published: 04 November 2025
View article titled, Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin
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Includes: Supplementary data
Journal Articles

A high-throughput zebrafish screen identifies novel candidate treatments for kaposiform lymphangiomatosis (KLA)

Ivan Bassi, Amani Jabali, Lotan Levin, Giuseppina Lambiase, Noga Moshe, Naama Farag, Yaara Tevet, Gal Perlmoter, Shany Egozi, Gil S. Leichner, Polina Geva, Aviv Barzilai, Camila Avivi, Jonathan Long, Jason J. Otterstrom, Yael Paran, Haim Barr, Karina Yaniv, Shoshana Greenberger
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20240513.
https://doi.org/10.1084/jem.20240513
Published: 21 August 2025
View article titled, A high-throughput zebrafish screen identifies novel candidate treatments for kaposiform lymphangiomatosis (KLA)
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Includes: Supplementary data
Journal Articles

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

In Special Collection:
Cytokines Collection 2025
Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M. Adrover
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20242402.
https://doi.org/10.1084/jem.20242402
Published: 11 August 2025
View article titled, Heart of the matter: Neutrophils, cancer, and cardiovascular disease
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Journal Articles

S1PR1, an endothelial-immune influencer

Samantha Mahfoud, Timothy P. Padera
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20251056.
https://doi.org/10.1084/jem.20251056
Published: 15 July 2025
View article titled, S1PR1, an endothelial-immune influencer
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Journal Articles

S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum

In Special Collection:
Cytokines Collection 2025
Xin Geng, Lijuan Chen, Zoheb Ahmed, Guilherme Pedron Formigari, Yen-Chun Ho, Ilaria Del Gaudio, Marcella Neves Datilo, Zheila J. Azartash-Namin, Coraline Heron, Xindi Shan, Ravi Shankar Keshari, Soumiya Pal, Hong Chen, Florea Lupu, Lijun Xia, Gwendalyn J. Randolph, Scott D. Zawieja, Eric Camerer, Michael J. Davis, R. Sathish Srinivasan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241799.
https://doi.org/10.1084/jem.20241799
Published: 24 June 2025
View article titled, S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum
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Includes: Supplementary data
Journal Articles

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration

In Special Collection:
JEM Clinical Immunology Collection 2025 , Macrophages and Dendritic Cells in Health and Disease , Neuroimmunology and Neurodegeneration 2025
Seth D. Fortmann, Blake F. Frey, Robert F. Rosencrans, Yvonne Adu-Rutledge, Edgar Ready V, Kameron V. Kilchrist, Robert S. Welner, Michael E. Boulton, Daniel R. Saban, Maria B. Grant
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20242007.
https://doi.org/10.1084/jem.20242007
Published: 22 April 2025
View article titled, Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration
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Includes: Supplementary data
Journal Articles

Factor XII–driven coagulation traps bacterial infections

Katrin F. Nickel, Anne Jämsä, Sandra Konrath, Praveen Papareddy, Lynn M. Butler, Evi X. Stavrou, Maike Frye, Mathias Gelderblom, Bernhard Nieswandt, Sven Hammerschmidt, Heiko Herwald, Thomas Renné
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20250049.
https://doi.org/10.1084/jem.20250049
Published: 22 April 2025
View article titled, Factor XII–driven coagulation traps bacterial infections
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Includes: Supplementary data
Journal Articles

The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish

Daniel Castranova, Madeleine I. Kenton, Aurora Kraus, Christopher W. Dell, Jong S. Park, Marina Venero Galanternik, Gilseung Park, Daniel N. Lumbantobing, Louis Dye, Miranda Marvel, James Iben, Kiyohito Taimatsu, Van Pham, Reegan J. Willms, Lucas Blevens, Tanner F. Robertson, Yiran Hou, Anna Huttenlocher, Edan Foley, Lynne R. Parenti, J. Kimble Frazer, Kedar Narayan, Brant M. Weinstein
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20241435.
https://doi.org/10.1084/jem.20241435
Published: 01 April 2025
View article titled, The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish
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Includes: Supplementary data
Journal Articles

An in-depth look at lung lymphatics

David G. Jackson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20250119.
https://doi.org/10.1084/jem.20250119
Published: 19 March 2025
View article titled, An in-depth look at lung lymphatics
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Journal Articles

Uniting education, research, healthcare, and society to advance women’s heart health

Michael Y. Schakelaar, Annemieke Maas, Anne-Mar L.N. van Ommen, Anna E. Spiering, Roos de Jonge, Patrick Wijchers, Gerda van Rossum, Balthasar A. Heesters, Olivier G. de Jong, Jelle Zandveld, Heggert G. Rebel, Jan Meeldijk, Emma W. Pijnappel, Suzanne van Dijk, Alessia Di Maggio, Olaf Nijssen, Jorine G.F. Sanders, Lies Hoogerwerf, Mike van Spaandonk, Sandra Crnko, Thijs Koorman, Kevin Jenniskens, N. Charlotte Onland-Moret, Stefan M. van Geelen, Toine ten Broeke, Annet van Royen-Kerkhof, Gönül Dilaver, Sabrina Oliveira, Robbert J. Kok, Linda W. van Laake, Pim van der Harst, Wilko Spiering, Frans H. Rutten, Marco van Brussel, Hester M. den Ruijter, Niels Bovenschen
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240877.
https://doi.org/10.1084/jem.20240877
Published: 15 October 2024
View article titled, Uniting education, research, healthcare, and society to advance women’s heart health
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Journal Articles

Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension

In Special Collection:
Immunometabolism 2025
Maki Niihori, Joel James, Mathews V. Varghese, Nolan McClain, Odunayo Susan Lawal, Rohit C. Philip, Brenda K. Baggett, Dmitry A. Goncharov, Vinicio de Jesus Perez, Elena A. Goncharova, Ruslan Rafikov, Olga Rafikova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231568.
https://doi.org/10.1084/jem.20231568
Published: 25 September 2024
View article titled, Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension
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Includes: Supplementary data
Journal Articles

Meningeal lymphatics can influence stroke outcome

Gou Young Koh, Donald M. McDonald
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20232305.
https://doi.org/10.1084/jem.20232305
Published: 05 March 2024
View article titled, Meningeal lymphatics can influence stroke outcome
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Journal Articles

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine
Ligia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee, Basavaraju G. Sanganahalli, Myriam Spajer, Shenqi Zhang, Sungwoon Lee, Maxime Parent, Yuechuan Xue, Mario Skarica, Xiangyun Yin, Justine Guegan, Kevin Boyé, Felipe Saceanu Leser, Laurent Jacob, Mathilde Poulet, Mingfeng Li, Xiaodan Liu, Sofia E. Velazquez, Ruchith Singhabahu, Mark E. Robinson, Michael H. Askenase, Artem Osherov, Nenad Sestan, Jiangbing Zhou, Kari Alitalo, Eric Song, Anne Eichmann, Lauren H. Sansing, Helene Benveniste, Fahmeed Hyder, Jean-Leon Thomas
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221983.
https://doi.org/10.1084/jem.20221983
Published: 05 March 2024
View article titled, VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
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Includes: Supplementary data
Journal Articles

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

In Special Collection:
Barrier Immunity , Immunology Update Winter 2024
Harald Lund, Matthew A. Hunt, Zerina Kurtović, Katalin Sandor, Paul B. Kägy, Noah Fereydouni, Anais Julien, Christian Göritz, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Alexandra Jurczak, Jinming Han, Keying Zhu, Robert A. Harris, Jon Lampa, Jonas Heilskov Graversen, Anders Etzerodt, Lisbet Haglund, Tony L. Yaksh, Camilla I. Svensson
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (2): e20230675.
https://doi.org/10.1084/jem.20230675
Published: 20 December 2023
View article titled, CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
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Includes: Supplementary data
Journal Articles

Mechanisms and functions of intestinal vascular specialization

In Special Collection:
Lymphatic Vessels in Health and Disease 2024
Jeremiah Bernier-Latmani, Alejandra González-Loyola, Tatiana V. Petrova
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20222008.
https://doi.org/10.1084/jem.20222008
Published: 05 December 2023
View article titled, Mechanisms and functions of intestinal vascular specialization
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Journal Articles

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

In Special Collection:
Lymphatic Vessels in Health and Disease 2024
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsäter, Michael Vanlandewijck, Bojana Jakic, Eulàlia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Mäkinen
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (4): e20220741.
https://doi.org/10.1084/jem.20220741
Published: 23 January 2023
View article titled, Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
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Includes: Supplementary data
Journal Articles

Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies

In Special Collection:
Innate Immune Cells and Signaling 2023
Achraf Shamseddine, Suchit H. Patel, Valery Chavez, Zachary R. Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T. Dang, Lakshmi V. Ramanathan, Kevin C. Oeffinger, Jennifer E. Liu, Richard M. Steingart, Alessandra Piersigilli, Nicholas D. Socci, Angel T. Chan, Anthony F. Yu, Samuel F. Bakhoum, Adam M. Schmitt
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (3): e20220809.
https://doi.org/10.1084/jem.20220809
Published: 19 December 2022
View article titled, Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies
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Includes: Supplementary data
Journal Articles

Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice

Corinne M. Nielsen, Xuetao Zhang, Kunal Raygor, Shaoxun Wang, Andrew W. Bollen, Rong A. Wang
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20211390.
https://doi.org/10.1084/jem.20211390
Published: 28 November 2022
View article titled, Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice
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Journal Articles

Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury

Hao He, Wu Yang, Nan Su, Chuankai Zhang, Jianing Dai, Feng Han, Mahak Singhal, Wenjuan Bai, Xiaolan Zhu, Jing Zhu, Zhen Liu, Wencheng Xia, Xiaoting Liu, Chonghe Zhang, Kai Jiang, Wenhui Huang, Dan Chen, Zhaoyin Wang, Xueyang He, Frank Kirchhoff, Zhenyu Li, Cong Liu, Jingning Huan, Xiaohong Wang, Wu Wei, Jing Wang, Hellmut G. Augustin, Junhao Hu
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20211422.
https://doi.org/10.1084/jem.20211422
Published: 09 November 2022
View article titled, Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury
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Includes: Supplementary data
Journal Articles

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schölch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut G. Augustin, Moritz Felcht
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (1): e20202595.
https://doi.org/10.1084/jem.20202595
Published: 21 October 2022
View article titled, Primary tumor–derived systemic nANGPTL4 inhibits metastasis
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Includes: Supplementary data