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Journal Articles

Leveraging cDC1 biology and function for enhanced immunotherapy

Ross W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (7): e20241199.
https://doi.org/10.1084/jem.20241199
Published: 10 June 2026
View article titled, Leveraging cDC1 biology and function for enhanced immunotherapy
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Journal Articles

Inhibitory receptor agonists: Emerging strategies in immune modulation

In Special Collection:
Inflammation Resolution 2026
Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo, Dario A.A. Vignali
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (4): e20241217.
https://doi.org/10.1084/jem.20241217
Published: 31 March 2026
View article titled, Inhibitory receptor agonists: Emerging strategies in immune modulation
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Journal Articles

Myeloid diversity in tumors: Shaped by genes, location, and time

In Special Collection:
JEM Cancer Collection 2026
Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, María Casanova-Acebes
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (4): e20252267.
https://doi.org/10.1084/jem.20252267
Published: 12 March 2026
View article titled, Myeloid diversity in tumors: Shaped by genes, location, and time
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Journal Articles

T cell engagers emerge as a compelling therapeutic modality

In Special Collection:
Immunology Update Winter 2026
P.A. Baeuerle, K. Sauer, R. Grieshaber-Bouyer, J.S. Michaelson
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 223 (2): e20251652.
https://doi.org/10.1084/jem.20251652
Published: 26 December 2025
View article titled, T cell engagers emerge as a compelling therapeutic modality
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Journal Articles

Advances in the development of personalized neoantigen therapies

Spencer E. Mirabile-Brightman, Lisa H. Butterfield
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 223 (2): e20241234.
https://doi.org/10.1084/jem.20241234
Published: 09 December 2025
View article titled, Advances in the development of personalized neoantigen therapies
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Journal Articles

CD4+ T cell dysfunction in cancer

Hrishi Venkatesh, Lawrence Fong
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (9): e20241417.
https://doi.org/10.1084/jem.20241417
Published: 07 August 2025
View article titled, CD4+ T cell dysfunction in cancer
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Journal Articles

YTHDFs as radiotherapy checkpoints in tumor immunity

In Special Collection:
JEM Cancer Immunotherapy 2025
Chuangyu Wen, Emile Z. Naccasha, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (8): e20250272.
https://doi.org/10.1084/jem.20250272
Published: 05 June 2025
View article titled, YTHDFs as radiotherapy checkpoints in tumor immunity
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Journal Articles

Microbiota-centered interventions to boost immune checkpoint blockade therapies

In Special Collection:
JEM Clinical Immunology Collection 2025
Andrew A. Almonte, Simon Thomas, Laurence Zitvogel
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (7): e20250378.
https://doi.org/10.1084/jem.20250378
Published: 22 April 2025
View article titled, Microbiota-centered interventions to boost immune checkpoint blockade therapies
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Journal Articles

Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment

In Special Collection:
Immunometabolism 2025
Ana Belén Plata-Gómez, Ping-Chih Ho
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (6): e20241102.
https://doi.org/10.1084/jem.20241102
Published: 11 April 2025
View article titled, Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment
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Journal Articles

Lymphatic transport in anti-tumor immunity and metastasis

In Special Collection:
JEM Cancer Collection 2025 , JEM Immunology Collection 2025
Mengzhu Sun, Julien Angelillo, Stéphanie Hugues
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (3): e20231954.
https://doi.org/10.1084/jem.20231954
Published: 19 February 2025
View article titled, Lymphatic transport in anti-tumor immunity and metastasis
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Journal Articles

Bridging the gap between tumor and disease: Innovating cancer and glioma models

In Special Collection:
JEM Cancer Collection 2025
Stefano M. Cirigliano, Howard A. Fine
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20220808.
https://doi.org/10.1084/jem.20220808
Published: 03 December 2024
View article titled, Bridging the gap between tumor and disease: Innovating cancer and glioma models
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Journal Articles

Genetic and environmental risks for clonal hematopoiesis and cancer

In Special Collection:
Immunology Update Winter 2025 , JEM Cancer Collection 2025
Stephanie Franco, Lucy A. Godley
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20230931.
https://doi.org/10.1084/jem.20230931
Published: 03 December 2024
View article titled, Genetic and environmental risks for clonal hematopoiesis and cancer
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Journal Articles

Aberrant pre-mRNA processing in cancer

In Special Collection:
JEM Cancer Collection 2025
Jeetayu Biswas, Leora Boussi, Eytan Stein, Omar Abdel-Wahab
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (11): e20230891.
https://doi.org/10.1084/jem.20230891
Published: 24 September 2024
View article titled, Aberrant pre-mRNA processing in cancer
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Journal Articles

The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes

In Special Collection:
Mechanisms and Models of Cancer 2024 , Tumor Metabolism 2025 , JEM Cancer Collection 2025 , Immunometabolism 2025
Mark Esposito, John K. Amory, Yibin Kang
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (9): e20240519.
https://doi.org/10.1084/jem.20240519
Published: 12 August 2024
View article titled, The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
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Journal Articles

Personalized cancer T-cell therapy takes the stage, mirroring vaccine success

Johanna Chiffelle, Alexandre Harari
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (8): e20240854.
https://doi.org/10.1084/jem.20240854
Published: 11 June 2024
View article titled, Personalized cancer T-cell therapy takes the stage, mirroring vaccine success
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Journal Articles

Radiotherapy and immunology

In Special Collection:
JEM Clinical Immunology Collection 2024 , Mechanisms and Models of Cancer 2024 , JEM Cancer Collection 2025
Liangliang Wang, Connor Lynch, Sean P. Pitroda, András Piffkó, Kaiting Yang, Amy K. Huser, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (7): e20232101.
https://doi.org/10.1084/jem.20232101
Published: 21 May 2024
View article titled, Radiotherapy and immunology
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Journal Articles

Hormonal basis of brain fog in cancer treatment

In Special Collection:
Neuroscience Collection 2024
Yuan Pan, Jian Hu
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (5): e20231942.
https://doi.org/10.1084/jem.20231942
Published: 10 April 2024
View article titled, Hormonal basis of brain fog in cancer treatment
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Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:
JEM Cancer Collection 2024 , Neuroscience Collection 2024
Morgan E. Freret, Adrienne Boire
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (4): e20212121.
https://doi.org/10.1084/jem.20212121
Published: 07 March 2024
View article titled, The anatomic basis of leptomeningeal metastasis
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Journal Articles

CAR-T cell manufacturing: Major process parameters and next-generation strategies

In Special Collection:
Cancer Immunotherapy Update 2024 , JEM Cancer Collection 2024
Melanie Ayala Ceja, Mobina Khericha, Caitlin M. Harris, Cristina Puig-Saus, Yvonne Y. Chen
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (2): e20230903.
https://doi.org/10.1084/jem.20230903
Published: 16 January 2024
View article titled, CAR-T cell manufacturing: Major process parameters and next-generation strategies
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Journal Articles

The PML hub: An emerging actor of leukemia therapies

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , JEM Cancer Collection 2024 , Myeloid Stem Cells and Leukemia 2024
Domitille Rérolle, Hugues de Thé
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2023) 220 (8): e20221213.
https://doi.org/10.1084/jem.20221213
Published: 29 June 2023
View article titled, The PML hub: An emerging actor of leukemia therapies
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