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Journal Articles
The Journal of Experimental Medicine (2020) 217 (2): e20200046.
Published: 21 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (3): e20191226.
Published: 20 January 2020
Includes: Supplementary data
Images
The dissipation of electrons (Δ Y ) in metabolic transformations.  Δ Y  is ...
Published: 20 January 2020
Figure 1. The dissipation of electrons (Δ Y ) in metabolic transformations. Δ Y is calculated by Eq. 2 based on the Y values in Table 1 and Table S1 . (A) Δ Y in ATP generation. The inset is mitochondrial ATP generation. (B) Δ Y in the biosynthesis of nucleosides. Ribose can be gen... More
Images
Intracellular metabolic overview.  The metabolic pathways were organized ba...
Published: 20 January 2020
Figure S1. Intracellular metabolic overview. The metabolic pathways were organized based on Berg et al. (2011) . The red arrows show the irreversible direction of the reactions. The synthesis of each nucleotide is summarized in Fig. S2 and Table S3 . 1,3-BPG, 1,3-bisphosphoglycerate; 2-PG, 2... More
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De novo biosynthesis of nucleosides.  (A)  Oxidative PPP. See  Fig. S1  for...
Published: 20 January 2020
Figure S2. De novo biosynthesis of nucleosides. (A) Oxidative PPP. See Fig. S1 for the detailed processes. (B) Non-oxidative PPP. The upper box is the overall conversion of glucose to ribose-5-phosphate, and the detailed reactions are shown in the lower box. (C) De novo biosyntheses of nu... More
Images
Glucose – derived metabolites upon ETC dysfunction.  (A and B)  Glucose uti...
Published: 20 January 2020
Figure S3. Glucose – derived metabolites upon ETC dysfunction. (A and B) Glucose utilization and lactate secretion in HeLa cells cultured with [U- 13 C]-glucose under the conditions of hypoxia or inhibition by antimycin A (1 µM). (C) Schematic for glucose metabolism. (D and E) Mass isotopom... More
Images
Glutamine - derived metabolites upon ETC dysfunction.  (A  –  F)  Mass isot...
Published: 20 January 2020
Figure S4. Glutamine - derived metabolites upon ETC dysfunction. (A – F) Mass isotopomer analysis of succinate, α-ketoglutarate, citrate, acetyl-CoA, malate, and aspartate in HeLa or 4T1 cells cultured with [U- 13 C]-glutamine under the condition of hypoxia or inhibition by antimycin A (1 µM)... More
Images
Glutamine-initiated lipogenesis upon ETC dysfunction.  (A)  Mass isotopomer...
Published: 20 January 2020
Figure 3. Glutamine-initiated lipogenesis upon ETC dysfunction. (A) Mass isotopomer analysis of acetyl-CoA in HeLa cells cultured with [U- 13 C]-glutamine for 8 h under the condition of hypoxia or inhibition by antimycin A (1 µM). (B) Labeled carbons in fatty acids in HeLa cells cultured with... More
Images
Glutamate flux to proline rescues cell proliferation under ETC dysfunction....
Published: 20 January 2020
Figure 4. Glutamate flux to proline rescues cell proliferation under ETC dysfunction. (A) A model to show that cells adapt to ETC dysfunction by metabolically excreting electrons. (B) Electron consumption of conversion of pyruvate, oxaloacetate, and glutamate to lactate and proline. (C) Wes... More
Images
Electron accumulation drives glutamine-initiated proline biosynthesis and l...
Published: 20 January 2020
Figure 5. Electron accumulation drives glutamine-initiated proline biosynthesis and lipogenesis. (A) 105 metabolites in HeLa cells significantly changed by hypoxia or antimycin A. Cells were treated under hypoxia or with antimycin A (1 µM) for 8 h. Metabolites were measured by LC-MS ( n = 6). ... More
Images
Hypoxia and antimycin A induce similar changes in metabolites but not in ge...
Published: 20 January 2020
Figure S5. Hypoxia and antimycin A induce similar changes in metabolites but not in gene expressions. (A) Metamapp visualization of metabolic changes in HeLa cells under the condition of hypoxia or inhibition by antimycin A (1 µM). Red nodes represent metabolites with increased signal intensity ... More
Images
Glutamine – derived proline biosynthesis and lipogenesis compensate each ot...
Published: 20 January 2020
Figure 6. Glutamine – derived proline biosynthesis and lipogenesis compensate each other under hypoxia. Δ Y /GMR refers to the overall Δ Y value for the equivalent of each glutamate-associated metabolic reaction. (A) A model to show the glutamate-initiated palmitate biosynthesis. (B) A mode... More
Images
Blocking proline biosynthesis sensitizes in vivo tumor to lipogenesis inhib...
Published: 20 January 2020
Figure 7. Blocking proline biosynthesis sensitizes in vivo tumor to lipogenesis inhibition. (A) Potential targets to block electron-consuming metabolic pathways. (B and C ) Simultaneous inhibition of P5CS, ACC1, and HMGR synergistically suppressed tumor growth in vivo. P5CS is the key enzyme... More
Images
Inhibiting proline biosynthesis and lipogenesis synergistically suppressed ...
Published: 20 January 2020
Figure 8. Inhibiting proline biosynthesis and lipogenesis synergistically suppressed in vivo tumor growth. (A) A schematic describes generation of a floxed (loxP flanked P5CS exon 4) mouse, P5CS fl/fl , using CRISPR/Cas9. (B) A schematic shows generation of a P5CS exon 4–deleted mouse, ... More
Journal Articles
The Journal of Experimental Medicine (2020) 217 (2): e20192335.
Published: 20 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (3): e20181757.
Published: 20 January 2020
Includes: Supplementary data
Images
Impact of injection and infection on macrophage phenotype in vitro.  (A)  P...
Published: 20 January 2020
Figure 1. Impact of injection and infection on macrophage phenotype in vitro. (A) Primary BMMøs from Ai6 mice were challenged with CEP-Cre-tdTomato, and at 24 hpi they were analyzed by flow cytometry for expression of tdTomato and ZsGreen. Populations were divided into fractions I (uninfected),... More
Images
Impact of injection and infection on BMMø phenotype  .  (A)  BMMøs from Ai6...
Published: 20 January 2020
Figure S1. Impact of injection and infection on BMMø phenotype . (A) BMMøs from Ai6 mice were challenged with CEP-Cre-tdTomato (CEP) or Pru-Cre-tdTomato (Pru), and fractions I–IV were assessed for pSTAT3. Bar graphs depict the MFI of pSTAT3 of cells from indicated fraction. Summary data from o... More
Images
Identification and analysis of macrophage populations from CEP-infected mic...
Published: 20 January 2020
Figure 2. Identification and analysis of macrophage populations from CEP-infected mice. (A) Ai6 mice were infected i.p. with 10 6 CEP-Cre-tdTomato, and at 1 dpi the PECs were analyzed by flow cytometry to identify resident LPM. The interactions of these subsets with CEP were analyzed by plotti... More
Images
Gene expression analysis of LPM from CEP-infected mice  .  (A)  Reads that ...
Published: 20 January 2020
Figure S2. Gene expression analysis of LPM from CEP-infected mice . (A) Reads that map to parasite transcriptome from sorted populations of uninfected (I), infected (III), and injected (IV) at 1 dpi with CEP. (B) Hierarchically clustered sorted samples from four replicated (rep) samples with... More