1-20 of 70715
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
The Journal of Experimental Medicine (2020) 217 (2): e20200046.
Published: 21 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (2): e20192335.
Published: 20 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (3): e20181757.
Published: 20 January 2020
Includes: Supplementary data
Images
Impact of injection and infection on macrophage phenotype in vitro.  (A)  P...
Published: 20 January 2020
Figure 1. Impact of injection and infection on macrophage phenotype in vitro. (A) Primary BMMøs from Ai6 mice were challenged with CEP-Cre-tdTomato, and at 24 hpi they were analyzed by flow cytometry for expression of tdTomato and ZsGreen. Populations were divided into fractions I (uninfected),... More
Images
Impact of injection and infection on BMMø phenotype  .  (A)  BMMøs from Ai6...
Published: 20 January 2020
Figure S1. Impact of injection and infection on BMMø phenotype . (A) BMMøs from Ai6 mice were challenged with CEP-Cre-tdTomato (CEP) or Pru-Cre-tdTomato (Pru), and fractions I–IV were assessed for pSTAT3. Bar graphs depict the MFI of pSTAT3 of cells from indicated fraction. Summary data from o... More
Images
Identification and analysis of macrophage populations from CEP-infected mic...
Published: 20 January 2020
Figure 2. Identification and analysis of macrophage populations from CEP-infected mice. (A) Ai6 mice were infected i.p. with 10 6 CEP-Cre-tdTomato, and at 1 dpi the PECs were analyzed by flow cytometry to identify resident LPM. The interactions of these subsets with CEP were analyzed by plotti... More
Images
Gene expression analysis of LPM from CEP-infected mice  .  (A)  Reads that ...
Published: 20 January 2020
Figure S2. Gene expression analysis of LPM from CEP-infected mice . (A) Reads that map to parasite transcriptome from sorted populations of uninfected (I), infected (III), and injected (IV) at 1 dpi with CEP. (B) Hierarchically clustered sorted samples from four replicated (rep) samples with... More
Images
Response of STAT6 −/−  and LysM-STAT3 mice to CEP infection.  (A)  To asses...
Published: 20 January 2020
Figure 3. Response of STAT6 −/− and LysM-STAT3 mice to CEP infection. (A) To assess the impact of infection on macrophage proliferation, Ai6 mice were injected i.p. with 10 6 CEP-Cre-tdTomato. At 1 dpi, LPM fractions I–IV were assessed by flow cytometry for expression of CD301b and Ki67. Repr... More
Images
Analysis of STAT6 −/−  and LysM-STAT3 mice during CEP infection  .  (A)  St...
Published: 20 January 2020
Figure S3. Analysis of STAT6 −/− and LysM-STAT3 mice during CEP infection . (A) Stat3 flox or LysM-STAT3 mice were infected i.p. with 10 5 CEP-Cre-tdTomato, and on 5 dpi parasite burden from the liver, lung, and PECs was measured by quantitative PCR. The amount of parasite DNA measured per... More
Images
Effect of depletion of ROP16 in CEP on macrophage polarization in vitro and...
Published: 20 January 2020
Figure 4. Effect of depletion of ROP16 in CEP on macrophage polarization in vitro and in vivo. (A) Primary Ai6 BMMøs were infected with CEP-Cre-tdTomato (CEP), CEP-Cre-tdTomato-Δ rop16 (Δ rop16 ), or CEP-Cre-tdTomato-Δ rop16 : rop III 16 (Δ rop16:rop III 16 ) parasites, and at 24 hpi, the abi... More
Images
Growth and control of CEP in BMMø is ROP16 independent  .  Resting BMMøs or...
Published: 20 January 2020
Figure S4. Growth and control of CEP in BMMø is ROP16 independent . Resting BMMøs or BMMøs stimulated with IFN-γ plus TNF for 10 h were infected with CEP or Δ rop16 , and 20–24 h later cytospins were used to calculate the percentage of cells infected and the numbers of parasites per infected ce... More
Images
Loss of ROP16 results in improved parasite control and enhanced T cell resp...
Published: 20 January 2020
Figure 5. Loss of ROP16 results in improved parasite control and enhanced T cell responses. (A) C57BL/6 mice were infected i.p. with 10 5 tachyzoites of CEP or Δ rop16 , and at 5 dpi, the percentage of infected PECs was determined by cytospin analysis. Summary data are representative of one of... More
Images
ROP16-dependent T cell response to CEP infection  .  (A and B)  To characte...
Published: 20 January 2020
Figure S5. ROP16-dependent T cell response to CEP infection . (A and B) To characterize the T cell response, splenocytes from CEP or Δ rop16 infected mice (10 dpi) were analyzed by flow cytometry for KLRG1 and CXCR3 on LFA1 hi or parasite-specific CD4 + (A) and CD8 + (B) T cells. Flow plot... More
Images
Images
The Aifantis lab, mid-2019, in the lobby of the new NYU Langone Research Bu...
Published: 20 January 2020
The Aifantis lab, mid-2019, in the lobby of the new NYU Langone Research Building. More
Journal Articles
The Journal of Experimental Medicine (2020) 217 (3): e20191226.
Published: 20 January 2020
Includes: Supplementary data
Images
The dissipation of electrons (Δ Y ) in metabolic transformations.  Δ Y  is ...
Published: 20 January 2020
Figure 1. The dissipation of electrons (Δ Y ) in metabolic transformations. Δ Y is calculated by Eq. 2 based on the Y values in Table 1 and Table S1 . (A) Δ Y in ATP generation. The inset is mitochondrial ATP generation. (B) Δ Y in the biosynthesis of nucleosides. Ribose can be gen... More
Images
Intracellular metabolic overview.  The metabolic pathways were organized ba...
Published: 20 January 2020
Figure S1. Intracellular metabolic overview. The metabolic pathways were organized based on Berg et al. (2011) . The red arrows show the irreversible direction of the reactions. The synthesis of each nucleotide is summarized in Fig. S2 and Table S3 . 1,3-BPG, 1,3-bisphosphoglycerate; 2-PG, 2... More
Images
De novo biosynthesis of nucleosides.  (A)  Oxidative PPP. See  Fig. S1  for...
Published: 20 January 2020
Figure S2. De novo biosynthesis of nucleosides. (A) Oxidative PPP. See Fig. S1 for the detailed processes. (B) Non-oxidative PPP. The upper box is the overall conversion of glucose to ribose-5-phosphate, and the detailed reactions are shown in the lower box. (C) De novo biosyntheses of nu... More
Images
Glucose – derived metabolites upon ETC dysfunction.  (A and B)  Glucose uti...
Published: 20 January 2020
Figure S3. Glucose – derived metabolites upon ETC dysfunction. (A and B) Glucose utilization and lactate secretion in HeLa cells cultured with [U- 13 C]-glucose under the conditions of hypoxia or inhibition by antimycin A (1 µM). (C) Schematic for glucose metabolism. (D and E) Mass isotopom... More