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Journal Articles

TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways

In Special Collection:

Cancer Immunotherapy Update 2024

Waipan Chan, Yuqi M. Cao, Xiang Zhao, Edward C. Schrom, Dongya Jia, Jian Song, Leah V. Sibener, Shen Dong, Ricardo A. Fernandes, Clinton J. Bradfield, Margery Smelkinson, Juraj Kabat, Jyh Liang Hor, Grégoire Altan-Bonnet, K. Christopher Garcia, Ronald N. Germain

J Exp Med (2023) 220 (12): e20231242.

https://doi.org/10.1084/jem.20231242

Published: 05 October 2023

View article titled, TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways

Includes: Supplementary data

Journal Articles

TGF-β regulates the stem-like state of PD-1⁺ TCF-1⁺ virus-specific CD8 T cells during chronic infection

Yinghong Hu, William H. Hudson, Haydn T. Kissick, Christopher B. Medina, Antonio P. Baptista, Chaoyu Ma, Wei Liao, Ronald N. Germain, Shannon J. Turley, Nu Zhang, Rafi Ahmed

J Exp Med (2022) 219 (10): e20211574.

https://doi.org/10.1084/jem.20211574

Published: 18 August 2022

View article titled, TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection

Includes: Supplementary data

Journal Articles

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

In Special Collection:

JEM Cancer Collection 2020

Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, Madhusudhanan Sukumar, Zhiya Yu, Jane Hu-Li, Takeshi Kawabe, Arunakumar Gangaplara, Rigel J. Kishton, Amanda N. Henning, Suman K. Vodnala, Ronald N. Germain, William E. Paul, Nicholas P. Restifo

J Exp Med (2019) 216 (11): 2619–2634.

https://doi.org/10.1084/jem.20181218

Published: 12 August 2019

View article titled, Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

Includes: Supplementary data

Journal Articles

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses

Luis M. Franco, Manasi Gadkari, Katherine N. Howe, Jing Sun, Lela Kardava, Parag Kumar, Sangeeta Kumari, Zonghui Hu, Iain D.C. Fraser, Susan Moir, John S. Tsang, Ronald N. Germain

J Exp Med (2019) 216 (2): 384–406.

https://doi.org/10.1084/jem.20180595

Published: 23 January 2019

View article titled, Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses

Includes: Supplementary data

Journal Articles

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

Ismail Sayin, Andrea J. Radtke, Laura A. Vella, Wenjie Jin, E. John Wherry, Marcus Buggert, Michael R. Betts, Ramin S. Herati, Ronald N. Germain, David H. Canaday

J Exp Med (2018) 215 (6): 1531–1542.

https://doi.org/10.1084/jem.20171940

Published: 16 May 2018

View article titled, Spatial distribution and function of T follicular regulatory cells in human lymph nodes

Includes: Supplementary data

Journal Articles

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

Michael Y. Gerner, Kerry A. Casey, Wolfgang Kastenmuller, Ronald N. Germain

J Exp Med (2017) 214 (10): 3105–3122.

https://doi.org/10.1084/jem.20170335

Published: 28 August 2017

View article titled, Dendritic cell and antigen dispersal landscapes regulate T cell immunity

Includes: Supplementary data

Journal Articles

Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells

Masashi Watanabe, Chiharu Fujihara, Andrea J. Radtke, Y. Jeffrey Chiang, Sumeena Bhatia, Ronald N. Germain, Richard J. Hodes

J Exp Med (2017) 214 (9): 2795–2810.

https://doi.org/10.1084/jem.20161955

Published: 02 August 2017

View article titled, Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells

Includes: Supplementary data

Journal Articles

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity

Andrew G. Levine, Saskia Hemmers, Antonio P. Baptista, Michail Schizas, Mehlika B. Faire, Bruno Moltedo, Catherine Konopacki, Marc Schmidt-Supprian, Ronald N. Germain, Piper M. Treuting, Alexander Y. Rudensky

J Exp Med (2017) 214 (3): 609–622.

https://doi.org/10.1084/jem.20161318

Published: 27 January 2017

View article titled, Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity

Journal Articles

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis

Wai Po Chong, Nicholas van Panhuys, Jun Chen, Phyllis B. Silver, Yingyos Jittayasothorn, Mary J. Mattapallil, Ronald N. Germain, Rachel R. Caspi

J Exp Med (2015) 212 (10): 1739–1752.

https://doi.org/10.1084/jem.20141678

Published: 07 September 2015

View article titled, NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis

Includes: Supplementary data

Journal Articles

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

Qian Zhang, Christopher G. Dove, Jyh Liang Hor, Heardley M. Murdock, Dara M. Strauss-Albee, Jordan A. Garcia, Judith N. Mandl, Rachael A. Grodick, Huie Jing, Devon B. Chandler-Brown, Timothy E. Lenardo, Greg Crawford, Helen F. Matthews, Alexandra F. Freeman, Richard J. Cornall, Ronald N. Germain, Scott N. Mueller, Helen C. Su

J Exp Med (2014) 211 (13): 2549–2566.

https://doi.org/10.1084/jem.20141307

Published: 24 November 2014

View article titled, DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

Includes: Supplementary data

Journal Articles

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

Masaru Ishii, Junichi Kikuta, Yutaka Shimazu, Martin Meier-Schellersheim, Ronald N. Germain

J Exp Med (2010) 207 (13): 2793–2798.

https://doi.org/10.1084/jem.20101474

Published: 06 December 2010

View article titled, Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

Includes: Supplementary data

Journal Articles

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

Marcello Chieppa, Maria Rescigno, Alex Y.C. Huang, Ronald N. Germain

J Exp Med (2006) 203 (13): 2841–2852.

https://doi.org/10.1084/jem.20061884

Published: 04 December 2006

View article titled, Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

Includes: Supplementary data

Journal Articles

Natural killer cell behavior in lymph nodes revealed by static and real-time imaging

Marc Bajénoff, Béatrice Breart, Alex Y.C. Huang, Hai Qi, Julie Cazareth, Veronique M. Braud, Ronald N. Germain, Nicolas Glaichenhaus

J Exp Med (2006) 203 (3): 619–631.

https://doi.org/10.1084/jem.20051474

Published: 27 February 2006

View article titled, Natural killer cell behavior in lymph nodes revealed by static and real-time imaging

Includes: Supplementary data

Journal Articles

Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

Clemens Scheinecker, Rebecca McHugh, Ethan M. Shevach, Ronald N. Germain

J Exp Med (2002) 196 (8): 1079–1090.

https://doi.org/10.1084/jem.20020991

Published: 21 October 2002

View article titled, Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

Includes: Supplementary data

Journal Articles

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

Kayo Inaba, Shannon Turley, Tomonori Iyoda, Fumiya Yamaide, Susumu Shimoyama, Caetano Reis e Sousa, Ronald N. Germain, Ira Mellman, Ralph M. Steinman

J Exp Med (2000) 191 (6): 927–936.

https://doi.org/10.1084/jem.191.6.927

Published: 13 March 2000

View article titled, The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

Journal Articles

Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

Flora Castellino, Philip E. Boucher, Katrin Eichelberg, Mark Mayhew, James E. Rothman, Alan N. Houghton, Ronald N. Germain

J Exp Med (1999) 191 (11): 1957–1964.

https://doi.org/10.1084/jem.191.11.1957

Published: 06 June 1999

View article titled, Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

Journal Articles

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8⁺ T Cells after Gene Gun Immunization

Angel Porgador, Kari R. Irvine, Akiko Iwasaki, Brian H. Barber, Nicholas P. Restifo, Ronald N. Germain

J Exp Med (1998) 188 (6): 1075–1082.

https://doi.org/10.1084/jem.188.6.1075

Published: 21 September 1998

View article titled, Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

Journal Articles

Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands

Behazine Combadière, Caetano Reis e Sousa, Ronald N. Germain, Michael J. Lenardo

J Exp Med (1998) 187 (3): 349–355.

https://doi.org/10.1084/jem.187.3.349

Published: 02 February 1998

View article titled, Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands

Journal Articles

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

Caetano Reis e Sousa, Sara Hieny, Tanya Scharton-Kersten, Dragana Jankovic, Hugues Charest, Ronald N. Germain, Alan Sher

J Exp Med (1997) 186 (11): 1819–1829.

https://doi.org/10.1084/jem.186.11.1819

Published: 01 December 1997

View article titled, In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

Journal Articles

Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4⁺ T Cells

Yasushi Itoh, Ronald N. Germain

J Exp Med (1997) 186 (5): 757–766.

https://doi.org/10.1084/jem.186.5.757

Published: 29 August 1997

View article titled, Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells

NARROW

TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways

TGF-β regulates the stem-like state of PD-1⁺ TCF-1⁺ virus-specific CD8 T cells during chronic infection

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

Natural killer cell behavior in lymph nodes revealed by static and real-time imaging

Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8⁺ T Cells after Gene Gun Immunization

Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4⁺ T Cells

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