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Matthias Geyer
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Journal Articles

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

In Special Collection:
Pattern Recognition Receptors and Beyond
Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert E. Hughes, Rusty Montgomery, Claudia P. Portillo, Paul Rubin, Taiz Salazar, Yan Wang, Shijun Yan, Barry A. Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V. Hochheiser, Hannes Buthmann, Dominic Ferber, Jane Torp, Wei Wang, Melanie Cranston, Chloe M. McKee, Thea J. Mawhinney, Emma C. McKay, Fehime K. Eroglu, Jasmin Kümmerle-Deschner, Alexander N.R. Weber, Bénédicte F. Py, Matthias Geyer, Rebecca C. Coll
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242403.
https://doi.org/10.1084/jem.20242403
Published: 02 September 2025
View article titled, Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action
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Includes: Supplementary data
Journal Articles

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation

In Special Collection:
Innate Immune Signaling: From Host Defense to Disease Pathogenesis , 2024: The Year in Experimental Medicine
Camille Cosson, Romane Riou, Danish Patoli, Tingting Niu, Amaury Rey, Marine Groslambert, Charlotte De Rosny, Elodie Chatre, Omran Allatif, Thomas Henry, Fabienne Venet, Florian Milhavet, Guilaine Boursier, Alexandre Belot, Yvan Jamilloux, Etienne Merlin, Agnès Duquesne, Gilles Grateau, Léa Savey, Alexandre Thibault Jacques Maria, Anne Pagnier, Solène Poutrel, Olivier Lambotte, Coralie Mallebranche, Samuel Ardois, Olivier Richer, Irène Lemelle, Frédéric Rieux-Laucat, Brigitte Bader-Meunier, Zahir Amoura, Isabelle Melki, Laurence Cuisset, Isabelle Touitou, Matthias Geyer, Sophie Georgin-Lavialle, Bénédicte F. Py
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20231200.
https://doi.org/10.1084/jem.20231200
Published: 26 March 2024
View article titled, Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation
Open the PDF for Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation in another window
Includes: Supplementary data
Journal Articles

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

In Special Collection:
Innate Immune Cells and Signaling 2023
Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D. Wuerth, Lisa D.J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kümmerer, Florian I. Schmidt
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (1): e20220837.
https://doi.org/10.1084/jem.20220837
Published: 31 October 2022
View article titled, P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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Includes: Supplementary data
Journal Articles

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Andrea Stutz, Carl-Christian Kolbe, Rainer Stahl, Gabor L. Horvath, Bernardo S. Franklin, Olivia van Ray, Rebecca Brinkschulte, Matthias Geyer, Felix Meissner, Eicke Latz
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (6): 1725–1736.
https://doi.org/10.1084/jem.20160933
Published: 02 May 2017
View article titled, NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
Open the PDF for NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain in another window
Includes: Supplementary data