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Keiji Hirota
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Journal Articles

Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice

In Special Collection:
Barrier Immunity , Immunology Update Winter 2024
Daiya Ohara, Yusuke Takeuchi, Hitomi Watanabe, Yoonha Lee, Hiroki Mukoyama, Toshiaki Ohteki, Gen Kondoh, Keiji Hirota
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20230923.
https://doi.org/10.1084/jem.20230923
Published: 05 January 2024
View article titled, Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM<sup>+</sup> DCIR2<sup>+</sup> cDC2s in mice
Open the PDF for Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM<sup>+</sup> DCIR2<sup>+</sup> cDC2s in mice in another window
Includes: Supplementary data
Journal Articles

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

In Special Collection:
Thymus, T Cell Development, and Inborn Errors , Autoimmunity: From Novel Mechanisms to Treatments
Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anais Llamas-Covarrubias, Satoshi Tanaka, Lin Jin, Ee Lyn Lim, Hiromasa Morikawa, Yohko Kitagawa, Shuji Akizuki, Yoshinaga Ito, Chihiro Fujimori, Keiji Hirota, Tosei Murase, Motomu Hashimoto, Junichi Higo, Rose Zamoyska, Ryuzo Ueda, Daron M. Standley, Noriko Sakaguchi, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20220386.
https://doi.org/10.1084/jem.20220386
Published: 01 December 2022
View article titled, Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease
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Includes: Supplementary data
Journal Articles

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

Kuibeom Ko, Sayuri Yamazaki, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2012) 209 (2): 423.
https://doi.org/10.1084/jem.200509402092c
Published: 13 February 2012
View article titled, Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3<sup>+</sup>CD25<sup>+</sup>CD4<sup>+</sup> regulatory T cells
Open the PDF for Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3<sup>+</sup>CD25<sup>+</sup>CD4<sup>+</sup> regulatory T cells in another window
Journal Articles

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Motomu Hashimoto, Keiji Hirota, Hiroyuki Yoshitomi, Shinji Maeda, Shin Teradaira, Shuji Akizuki, Paz Prieto-Martin, Takashi Nomura, Noriko Sakaguchi, Jörg Köhl, Birgitta Heyman, Minoru Takahashi, Teizo Fujita, Tsuneyo Mimori, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (6): 1135–1143.
https://doi.org/10.1084/jem.20092301
Published: 10 May 2010
View article titled, Complement drives Th17 cell differentiation and triggers autoimmune arthritis
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Includes: Supplementary data
Journal Articles

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

Marc Veldhoen, Keiji Hirota, Jillian Christensen, Anne O'Garra, Brigitta Stockinger
Journal: Journal of Experimental Medicine
J Exp Med (2008) 206 (1): 43–49.
https://doi.org/10.1084/jem.20081438
Published: 29 December 2008
View article titled, Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
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Includes: Supplementary data
Journal Articles

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto, Shinji Maeda, Shin Teradaira, Naoshi Sugimoto, Tomoyuki Yamaguchi, Takashi Nomura, Hiromu Ito, Takashi Nakamura, Noriko Sakaguchi, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2007) 204 (12): 2803–2812.
https://doi.org/10.1084/jem.20071397
Published: 19 November 2007
View article titled, Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
Open the PDF for Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model in another window
Includes: Supplementary data
Journal Articles

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Keiji Hirota, Motomu Hashimoto, Hiroyuki Yoshitomi, Satoshi Tanaka, Takashi Nomura, Tomoyuki Yamaguchi, Yoichiro Iwakura, Noriko Sakaguchi, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2007) 204 (1): 41–47.
https://doi.org/10.1084/jem.20062259
Published: 16 January 2007
View article titled, T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17<sup>+</sup> Th cells that cause autoimmune arthritis
Open the PDF for T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17<sup>+</sup> Th cells that cause autoimmune arthritis in another window
Includes: Supplementary data
Journal Articles

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells

Kuibeom Ko, Sayuri Yamazaki, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2005) 202 (7): 885–891.
https://doi.org/10.1084/jem.20050940
Published: 26 September 2005
View article titled, Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3<sup> + </sup>CD25<sup> + </sup>CD4<sup> + </sup> regulatory T cells
Open the PDF for Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3<sup> + </sup>CD25<sup> + </sup>CD4<sup> + </sup> regulatory T cells in another window
Includes: Supplementary data
Journal Articles

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Hiroyuki Yoshitomi, Noriko Sakaguchi, Katsuya Kobayashi, Gordon D. Brown, Tomoyuki Tagami, Toshiko Sakihama, Keiji Hirota, Satoshi Tanaka, Takashi Nomura, Ichiro Miki, Siamon Gordon, Shizuo Akira, Takashi Nakamura, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2005) 201 (6): 949–960.
https://doi.org/10.1084/jem.20041758
Published: 21 March 2005
View article titled, A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
Open the PDF for A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice in another window
Includes: Supplementary data