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K F Austen
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Journal Articles

Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood.

N Ghildyal, D S Friend, R L Stevens, K F Austen, C Huang, J F Penrose, A Sali, M F Gurish
Journal: Journal of Experimental Medicine
J Exp Med (1996) 184 (3): 1061–1073.
https://doi.org/10.1084/jem.184.3.1061
Published: 01 September 1996
View article titled, Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood.
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Journal Articles

Sorting out the cytokines of asthma.

J M Drazen, J P Arm, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1996) 183 (1): 1–5.
https://doi.org/10.1084/jem.183.1.1
Published: 01 January 1996
View article titled, Sorting out the cytokines of asthma.
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Journal Articles

The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase.

M Murakami, K F Austen, J P Arm
Journal: Journal of Experimental Medicine
J Exp Med (1995) 182 (1): 197–206.
https://doi.org/10.1084/jem.182.1.197
Published: 01 July 1995
View article titled, The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase.
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Journal Articles

Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate.

J A Boyce, D Friend, R Matsumoto, K F Austen, W F Owen
Journal: Journal of Experimental Medicine
J Exp Med (1995) 182 (1): 49–57.
https://doi.org/10.1084/jem.182.1.49
Published: 01 July 1995
View article titled, Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate.
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Journal Articles

Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates.

K K Eklund, N Ghildyal, K F Austen, D S Friend, V Schiller, R L Stevens
Journal: Journal of Experimental Medicine
J Exp Med (1994) 180 (1): 67–73.
https://doi.org/10.1084/jem.180.1.67
Published: 01 July 1994
View article titled, Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates.
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Journal Articles

Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand.

M F Gurish, N Ghildyal, H P McNeil, K F Austen, S Gillis, R L Stevens
Journal: Journal of Experimental Medicine
J Exp Med (1992) 175 (4): 1003–1012.
https://doi.org/10.1084/jem.175.4.1003
Published: 01 April 1992
View article titled, Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand.
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Journal Articles

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

W F Owen, M E Rothenberg, J Petersen, P F Weller, D Silberstein, A L Sheffer, R L Stevens, R J Soberman, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1989) 170 (1): 343–348.
https://doi.org/10.1084/jem.170.1.343
Published: 01 July 1989
View article titled, Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.
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Journal Articles

Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts.

W F Owen, Jr, M E Rothenberg, D S Silberstein, J C Gasson, R L Stevens, K F Austen, R J Soberman
Journal: Journal of Experimental Medicine
J Exp Med (1987) 166 (1): 129–141.
https://doi.org/10.1084/jem.166.1.129
Published: 01 July 1987
View article titled, Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts.
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Journal Articles

Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells.

K Otsu, T Nakano, Y Kanakura, H Asai, H R Katz, K F Austen, R L Stevens, S J Galli, Y Kitamura
Journal: Journal of Experimental Medicine
J Exp Med (1987) 165 (3): 615–627.
https://doi.org/10.1084/jem.165.3.615
Published: 01 March 1987
View article titled, Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells.
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Journal Articles

Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.

R P MacDermott, R E Schmidt, J P Caulfield, A Hein, G T Bartley, J Ritz, S F Schlossman, K F Austen, R L Stevens
Journal: Journal of Experimental Medicine
J Exp Med (1985) 162 (6): 1771–1787.
https://doi.org/10.1084/jem.162.6.1771
Published: 01 December 1985
View article titled, Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.
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Journal Articles

IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells.

E Razin, J M Mencia-Huerta, R L Stevens, R A Lewis, F T Liu, E Corey, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1983) 157 (1): 189–201.
https://doi.org/10.1084/jem.157.1.189
Published: 01 January 1983
View article titled, IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells.
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Journal Articles

Mast cell mediator release as a function of cyclic AMP-dependent protein kinase activation.

C M Winslow, R A Lewis, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1981) 154 (4): 1125–1133.
https://doi.org/10.1084/jem.154.4.1125
Published: 01 October 1981
View article titled, Mast cell mediator release as a function of cyclic AMP-dependent protein kinase activation.
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Journal Articles

Functional characterization of synthetic leukotriene B and its stereochemical isomers.

R A Lewis, E J Goetzl, J M Drazen, N A Soter, K F Austen, E J Corey
Journal: Journal of Experimental Medicine
J Exp Med (1981) 154 (4): 1243–1248.
https://doi.org/10.1084/jem.154.4.1243
Published: 01 October 1981
View article titled, Functional characterization of synthetic leukotriene B and its stereochemical isomers.
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Journal Articles

Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.

M D Kazatchkine, D T Fearon, J E Silbert, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1979) 150 (5): 1202–1215.
https://doi.org/10.1084/jem.150.5.1202
Published: 01 November 1979
View article titled, Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.
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Journal Articles

Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.

J M Weiler, R W Yurt, D T Fearon, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1978) 147 (2): 409–421.
https://doi.org/10.1084/jem.147.2.409
Published: 01 February 1978
View article titled, Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.
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Journal Articles

Structural determinants of the eosinophil: chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis.

E J Goetzl, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1976) 144 (6): 1424–1437.
https://doi.org/10.1084/jem.144.6.1424
Published: 01 December 1976
View article titled, Structural determinants of the eosinophil: chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis.
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Journal Articles

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

D T Fearon, K F Austen
Journal: Journal of Experimental Medicine
J Exp Med (1975) 142 (4): 856–863.
https://doi.org/10.1084/jem.142.4.856
Published: 01 October 1975
View article titled, Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.
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Journal Articles

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : III. EFFECT OF CARBON MONOXIDE, CYANIDE, SALICYLALDOXIME, AND IONIC STRENGTH

K. F. Austen, W. E. Brocklehurst
Journal: Journal of Experimental Medicine
J Exp Med (1961) 114 (1): 29–42.
https://doi.org/10.1084/jem.114.1.29
Published: 01 July 1961
View article titled, ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : <subtitle>III. E<sc>FFECT OF</sc> C<sc>ARBON</sc> M<sc>ONOXIDE</sc>, C<sc>YANIDE</sc>, S<sc>ALICYLALDOXIME, AND</sc> I<sc>ONIC</sc> S<sc>TRENGTH </sc></subtitle>
Open the PDF for ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : <subtitle>III. E<sc>FFECT OF</sc> C<sc>ARBON</sc> M<sc>ONOXIDE</sc>, C<sc>YANIDE</sc>, S<sc>ALICYLALDOXIME, AND</sc> I<sc>ONIC</sc> S<sc>TRENGTH </sc></subtitle> in another window
Journal Articles

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : II. ENHANCEMENT OF THE ANAPHYLACTIC RELEASE OF HISTAMINE AND SLOW REACTING SUBSTANCE BY CERTAIN DIBASIC ALIPHATIC ACIDS AND INHIBITION BY MONOBASIC FATTY ACIDS

K. F. Austen, W. E. Brocklehurst
Journal: Journal of Experimental Medicine
J Exp Med (1961) 113 (3): 541–557.
https://doi.org/10.1084/jem.113.3.541
Published: 01 March 1961
View article titled, ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : <subtitle>II. E<sc>NHANCEMENT OF THE</sc> A<sc>NAPHYLACTIC</sc> R<sc>ELEASE OF</sc> H<sc>ISTAMINE AND</sc> S<sc>LOW</sc> R<sc>EACTING</sc> S<sc>UBSTANCE BY</sc> C<sc>ERTAIN</sc> D<sc>IBASIC</sc> A<sc>LIPHATIC</sc> A<sc>CIDS AND</sc> I<sc>NHIBITION BY</sc> M<sc>ONOBASIC</sc> F<sc>ATTY</sc> A<sc>CIDS </sc></subtitle>
Open the PDF for ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : <subtitle>II. E<sc>NHANCEMENT OF THE</sc> A<sc>NAPHYLACTIC</sc> R<sc>ELEASE OF</sc> H<sc>ISTAMINE AND</sc> S<sc>LOW</sc> R<sc>EACTING</sc> S<sc>UBSTANCE BY</sc> C<sc>ERTAIN</sc> D<sc>IBASIC</sc> A<sc>LIPHATIC</sc> A<sc>CIDS AND</sc> I<sc>NHIBITION BY</sc> M<sc>ONOBASIC</sc> F<sc>ATTY</sc> A<sc>CIDS </sc></subtitle> in another window
Journal Articles

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : I. EFFECT OF PEPTIDASE SUBSTRATES AND INHIBITORS

K. F. Austen, W. E. Brocklehurst
Journal: Journal of Experimental Medicine
J Exp Med (1961) 113 (3): 521–539.
https://doi.org/10.1084/jem.113.3.521
Published: 01 March 1961
View article titled, ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : <subtitle>I. E<sc>FFECT OF</sc> P<sc>EPTIDASE</sc> S<sc>UBSTRATES AND</sc> I<sc>NHIBITORS </sc></subtitle>
Open the PDF for ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : <subtitle>I. E<sc>FFECT OF</sc> P<sc>EPTIDASE</sc> S<sc>UBSTRATES AND</sc> I<sc>NHIBITORS </sc></subtitle> in another window