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John Q. Trojanowski
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Journal Articles

α-Synuclein modulates tau spreading in mouse brains

In Special Collection:
Neurodegenerative Diseases: Biology & Therapeutics , Neurodegenerative Diseases: Emerging Mechanisms and Therapeutic Opportunities
Fares Bassil, Emily S. Meymand, Hannah J. Brown, Hong Xu, Timothy O. Cox, Shankar Pattabhiraman, Chantal M. Maghames, Qihui Wu, Bin Zhang, John Q. Trojanowski, Virginia M.-Y. Lee
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (1): e20192193.
https://doi.org/10.1084/jem.20192193
Published: 22 October 2020
View article titled, α-Synuclein modulates tau spreading in mouse brains
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Includes: Supplementary data
Journal Articles

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau

In Special Collection:
Neurodegeneration and Neuroinflammation 2020
Sneha Narasimhan, Lakshmi Changolkar, Dawn M. Riddle, Alexandra Kats, Anna Stieber, Sarah A. Weitzman, Bin Zhang, Zhiyong Li, Erik D. Roberson, John Q. Trojanowski, Virginia M.Y. Lee
Journal: Journal of Experimental Medicine
J Exp Med (2019) 217 (2): e20190783.
https://doi.org/10.1084/jem.20190783
Published: 11 December 2019
View article titled, Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
Open the PDF for Human tau pathology transmits glial tau aggregates in the absence of neuronal tau in another window
Includes: Supplementary data
Journal Articles

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

In Special Collection:
Neurodegeneration and Neuroinflammation
Heidi Martini-Stoica, Allysa L. Cole, Daniel B. Swartzlander, Fading Chen, Ying-Wooi Wan, Lakshya Bajaj, David A. Bader, Virginia M.Y. Lee, John Q. Trojanowski, Zhandong Liu, Marco Sardiello, Hui Zheng
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (9): 2355–2377.
https://doi.org/10.1084/jem.20172158
Published: 14 August 2018
View article titled, TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
Open the PDF for TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading in another window
Includes: Supplementary data
Journal Articles

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

Jing L. Guo, Sneha Narasimhan, Lakshmi Changolkar, Zhuohao He, Anna Stieber, Bin Zhang, Ronald J. Gathagan, Michiyo Iba, Jennifer D. McBride, John Q. Trojanowski, Virginia M.Y. Lee
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (12): 2635–2654.
https://doi.org/10.1084/jem.20160833
Published: 17 October 2016
View article titled, Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
Open the PDF for Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice in another window
Includes: Supplementary data
Journal Articles

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

Nolwen L. Rey, Jennifer A. Steiner, Nazia Maroof, Kelvin C. Luk, Zachary Madaj, John Q. Trojanowski, Virginia M.-Y. Lee, Patrik Brundin
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (9): 1759–1778.
https://doi.org/10.1084/jem.20160368
Published: 08 August 2016
View article titled, Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
Open the PDF for Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease in another window
Includes: Supplementary data
Journal Articles

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

Kelvin C. Luk, Victoria M. Kehm, Bin Zhang, Patrick O’Brien, John Q. Trojanowski, Virginia M.Y. Lee
Journal: Journal of Experimental Medicine
J Exp Med (2012) 209 (5): 975–986.
https://doi.org/10.1084/jem.20112457
Published: 16 April 2012
View article titled, Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Open the PDF for Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice in another window
Includes: Supplementary data