1. Injection of a solution of peptone directly into the artery of the leg of a dog is followed by an abrupt increase in leg volume. This is of short duration and is quickly followed, usually in less than ½ minute, by a decrease in the volume of the limb below that previous to the injection. 2. The phases of the leg volume curve bear a fairly definite relation to the changes in arterial pressure. 3. These results, therefore, indicate that the long continued low arterial pressure in peptone shock, and probably in anaphylactic shock, may be hastened but is not maintained by peripheral dilatation, and suggest that there is an impounding of the blood in some other part of the body.

1. Glycerol extracts of liver, spleen, and kidney contain an ereptic ferment capable of splitting peptone into amino-acids. 2. Poisoning by phosphorus appears to reduce the ereptic power of the liver, and to a less extent that of the kidneys. 3. Poisoning by chloroform appears to have no appreciable effect upon the ereptase content of the liver, spleen, or kidneys. 4. Feeding of sugar to normal animals has little or no effect upon the ereptic power of the liver, spleen, or kidneys. 5. Feeding of sugar before and after poisoning with phosphorus appears to prevent the reduction of ereptic power of the liver.

1. Clear, filtered glycerol extracts of chopped liver, spleen, and kidney contain an ester-splitting ferment. 2. The esterase content of extracts of the liver and spleen of normal dogs is reasonably constant. 3. The amount of esterase in the liver does not appear to vary to any great extent from the normal, in poisoning with chloroform and phosphorus. 4. Feeding large quantities of sugar and increasing the amount of glycogen in the liver is accompanied by a marked increase in the esterase content of that organ. This increase is also evident in phosphorus-poisoned animals which have been fed large amounts of sugar. 5. The feeding of sugar does not prevent the increase in esterase in the blood serum of animals poisoned with phosphorus. 6. The esterolytic power of extracts of the kidney varies considerably in different dogs.

1. In peptone shock there is a marked, precipitate fall in arterial pressure. At the same time there is a fall in venous pressure. 2. In experimental fat embolism, ( a ) the fall in blood pressure is always gradual; ( b ) approximately 1 cc. of oil for each pound of body weight must be injected before a lasting fall in arterial pressure is produced; ( c ) it makes only a slight difference whether this amount is injected in small doses at a time or in relatively large quantities; and ( d ) when the arterial pressure falls, but not till then, the venous pressure rises. 3. In peptone shock, dyspnea, by its suction and force-pump action upon the reservoir of stagnating blood in the liver, brings more blood to the heart and causes a rise in arterial pressure. By repeatedly inducing short periods of dyspnea at frequent intervals, permanently beneficial results are obtained and the life of the animal can be saved. 4. In experimental fat embolism, dyspnea will cause a rise in blood pressure. But permanently beneficial results have not been obtained by this method. If dyspnea is found to bring permanent improvement in surgical shock, it is indirect evidence that this condition is not due to fat embolism. Respiratory suction is probably not responsible for the rise in blood pressure in experimental fat embolism. It seems more likely that the dyspnea in some way facilitates the passage of blood through the embarrassed pulmonary circulation. Artificial respiration with a bellows will also frequently cause a rise in blood pressure in experimental fat embolism. 5. In peptone shock the respiration is usually not affected, although there is some evidence that the respiratory center may be in a state of increased irritability. In experimental fat embolism, in some animals a violent dyspnea develops spontaneously. This is usually accompanied by edema of the lungs. In other instances, an apnea occurs, even before the blood pressure has begun to decline.

1. Spores of the Bacillus welchii group of bacteria were found on 100 per cent of the uniforms of Belgian soldiers who had come directly from the trenches, and in the meshes of all the samples examined of the new cloth from which the uniforms were made. 2. In fifteen out of twenty fresh war wounds members of this group of bacteria were found. Of the fifteen patients, only three later developed gas gangrene. Once the spores of Bacillus welchii have been carried into a wound the deep-lying lacerated muscle tissue appears to be the most important factor in the onset of gas gangrene. 3. Bacillus welchii is able to grow and produce gas in broth containing up to 40 per cent saccharose. Some strains were able to multiply and produce gas in 50 per cent saccharose broth; but none of those examined were able to grow when the concentration of the sugar reached 60 per cent. 4. The bubbling of pure oxygen through milk or dextrose broth cultures of Bacillus welchii has a definite depressor action on the production of gas. This does not appear to be-due to a reduced number of organisms in the culture.