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Jürgen Ruland
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Journal Articles

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

In Special Collection:
JEM Hematologic Malignancies Collection 2021
Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (2): e20200517.
https://doi.org/10.1084/jem.20200517
Published: 14 October 2020
View article titled, Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia
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Includes: Supplementary data
Journal Articles

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer

Julia Varga, Adele Nicolas, Valentina Petrocelli, Marina Pesic, Abdelrahman Mahmoud, Birgitta E. Michels, Emre Etlioglu, Diego Yepes, Björn Häupl, Paul K. Ziegler, Katrin Bankov, Peter J. Wild, Stefan Wanninger, Hind Medyouf, Henner F. Farin, Sabine Tejpar, Thomas Oellerich, Jürgen Ruland, Christian W. Siebel, Florian R. Greten
Journal: Journal of Experimental Medicine
J Exp Med (2020) 217 (10): e20191515.
https://doi.org/10.1084/jem.20191515
Published: 04 August 2020
View article titled, AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer
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Includes: Supplementary data
Journal Articles

The Nlrp3 inflammasome regulates acute graft-versus-host disease

Dragana Jankovic, Jayanthi Ganesan, Michael Bscheider, Natalie Stickel, Felix C. Weber, Greta Guarda, Marie Follo, Dietmar Pfeifer, Aubry Tardivel, Kristina Ludigs, Abdellatif Bouazzaoui, Katrin Kerl, Julius C. Fischer, Tobias Haas, Annette Schmitt-Gräff, Anand Manoharan, Leonard Müller, Jürgen Finke, Stefan F. Martin, Oliver Gorka, Christian Peschel, Jürgen Ruland, Marco Idzko, Justus Duyster, Ernst Holler, Lars E. French, Hendrik Poeck, Emmanuel Contassot, Robert Zeiser
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (10): 1899–1910.
https://doi.org/10.1084/jem.20130084
Published: 26 August 2013
View article titled, The Nlrp3 inflammasome regulates acute graft-versus-host disease
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Journal Articles

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

Konstanze Pechloff, Julian Holch, Uta Ferch, Marc Schweneker, Kristina Brunner, Markus Kremer, Tim Sparwasser, Leticia Quintanilla-Martinez, Ursula Zimber-Strobl, Berthold Streubel, Andreas Gewies, Christian Peschel, Jürgen Ruland
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (5): 1031–1044.
https://doi.org/10.1084/jem.20092042
Published: 03 May 2010
View article titled, The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma
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Includes: Supplementary data
Journal Articles

The adaptor molecule CARD9 is essential for tuberculosis control

Anca Dorhoi, Christiane Desel, Vladimir Yeremeev, Lydia Pradl, Volker Brinkmann, Hans-Joachim Mollenkopf, Karin Hanke, Olaf Gross, Jürgen Ruland, Stefan H.E. Kaufmann
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (4): 777–792.
https://doi.org/10.1084/jem.20090067
Published: 29 March 2010
View article titled, The adaptor molecule CARD9 is essential for tuberculosis control
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Includes: Supplementary data
Journal Articles

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets

Michael W. Tusche, Lesley A. Ward, Frances Vu, Doug McCarthy, Miguel Quintela-Fandino, Jurgen Ruland, Jennifer L. Gommerman, Tak W. Mak
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (12): 2671–2683.
https://doi.org/10.1084/jem.20091802
Published: 16 November 2009
View article titled, Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets
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Includes: Supplementary data
Journal Articles

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

Uta Ferch, Bernhard Kloo, Andreas Gewies, Vera Pfänder, Michael Düwel, Christian Peschel, Daniel Krappmann, Jürgen Ruland
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (12): 2851.
https://doi.org/10.1084/jem.20091167102109c
Published: 02 November 2009
View article titled, Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells
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Journal Articles

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

Uta Ferch, Bernhard Kloo, Andreas Gewies, Vera Pfänder, Michael Düwel, Christian Peschel, Daniel Krappmann, Jürgen Ruland
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (11): 2313–2320.
https://doi.org/10.1084/jem.20091167
Published: 19 October 2009
View article titled, Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells
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Journal Articles

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Matthew J. Robinson, Fabiola Osorio, Marcela Rosas, Rui P. Freitas, Edina Schweighoffer, Olaf Groß, J. Sjef Verbeek, Jürgen Ruland, Victor Tybulewicz, Gordon D. Brown, Luis Ferreira Moita, Philip R. Taylor, Caetano Reis e Sousa
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (9): 2037–2051.
https://doi.org/10.1084/jem.20082818
Published: 24 August 2009
View article titled, Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
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Includes: Supplementary data
Journal Articles

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation

Kerstin Werninghaus, Anna Babiak, Olaf Groß, Christoph Hölscher, Harald Dietrich, Else Marie Agger, Jörg Mages, Attila Mocsai, Hanne Schoenen, Katrin Finger, Falk Nimmerjahn, Gordon D. Brown, Carsten Kirschning, Antje Heit, Peter Andersen, Hermann Wagner, Jürgen Ruland, Roland Lang
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (1): 89–97.
https://doi.org/10.1084/jem.20081445
Published: 12 January 2009
View article titled, Adjuvanticity of a synthetic cord factor analogue for subunit <em>Mycobacterium tuberculosis</em> vaccination requires FcRγ–Syk–Card9–dependent innate immune activation
Open the PDF for Adjuvanticity of a synthetic cord factor analogue for subunit <em>Mycobacterium tuberculosis</em> vaccination requires FcRγ–Syk–Card9–dependent innate immune activation in another window
Includes: Supplementary data