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Journal Articles

Advances toward structure-based drug discovery for inflammasome targets

Li Wang, Michael A. Crackower, Hao Wu
Journal: Journal of Experimental Medicine
J Exp Med (2021) 219 (1): e20211147.
DOI: https://doi.org/10.1084/jem.20211147
Published: 16 November 2021
View article titled, Advances toward structure-based drug discovery for inflammasome targets
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Journal Articles

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

In Special Collection:
The Inflammasomes: From Mechanism to Therapeutics
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (11): e20201656.
DOI: https://doi.org/10.1084/jem.20201656
Published: 23 September 2021
View article titled, BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Click here to open pdf in another window PDF for BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Includes: Supplementary data
Journal Articles

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Florian I. Schmidt, Alvin Lu, Jeff W. Chen, Jianbin Ruan, Catherine Tang, Hao Wu, Hidde L. Ploegh
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (5): 771–790.
DOI: https://doi.org/10.1084/jem.20151790
Published: 11 April 2016
View article titled, A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
Click here to open pdf in another window PDF for A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
Includes: Supplementary data