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Journal Articles

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development

In Special Collection:

B Cells, T Cells, Vaccines 2019

Lijuan Zhao, Richard L. Frock, Zhou Du, Jiazhi Hu, Liang Chen, Michael S. Krangel, Frederick W. Alt

J Exp Med (2016) 213 (9): 1921–1936.

https://doi.org/10.1084/jem.20160670

Published: 15 August 2016

View article titled, Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development

Includes: Supplementary data

Journal Articles

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Cristian Boboila, Catherine Yan, Duane R. Wesemann, Mila Jankovic, Jing H. Wang, John Manis, Andre Nussenzweig, Michel Nussenzweig, Frederick W. Alt

J Exp Med (2013) 210 (3): 641.

https://doi.org/10.1084/jem.200924492103c

Published: 11 March 2013

View article titled, Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Journal Articles

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Duane R. Wesemann, Jennifer M. Magee, Cristian Boboila, Dinis Pedro Calado, Michael P. Gallagher, Andrew J. Portuguese, John P. Manis, Xiaolong Zhou, Mike Recher, Klaus Rajewsky, Luigi D. Notarangelo, Frederick W. Alt

J Exp Med (2011) 208 (13): 2733–2746.

https://doi.org/10.1084/jem.20111155

Published: 05 December 2011

View article titled, Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Journal Articles

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

Beena Patricia Jeevan-Raj, Isabelle Robert, Vincent Heyer, Adeline Page, Jing H. Wang, Florence Cammas, Frederick W. Alt, Régine Losson, Bernardo Reina-San-Martin

J Exp Med (2011) 208 (8): 1649–1660.

https://doi.org/10.1084/jem.20110118

Published: 11 July 2011

View article titled, Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

Includes: Supplementary data

Journal Articles

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Shan Zha, Craig H. Bassing, Takaomi Sanda, James W. Brush, Harin Patel, Peter H. Goff, Michael M. Murphy, Suprawee Tepsuporn, Richard A. Gatti, A. Thomas Look, Frederick W. Alt

J Exp Med (2010) 207 (7): 1369–1380.

https://doi.org/10.1084/jem.20100285

Published: 21 June 2010

View article titled, ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Includes: Supplementary data

Journal Articles

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

J Exp Med (2010) 207 (7): 1541–1554.

https://doi.org/10.1084/jem.20091927

Published: 14 June 2010

View article titled, Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

Includes: Supplementary data

Journal Articles

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Lisa S. Westerberg, Parool Meelu, Marisa Baptista, Michelle A. Eston, David A. Adamovich, Vinicius Cotta-de-Almeida, Brian Seed, Michael K. Rosen, Peter Vandenberghe, Adrian J. Thrasher, Christoph Klein, Frederick W. Alt, Scott B. Snapper

J Exp Med (2010) 207 (6): 1145–1152.

https://doi.org/10.1084/jem.20091245

Published: 31 May 2010

View article titled, Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Includes: Supplementary data

Journal Articles

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Cristian Boboila, Catherine Yan, Duane R. Wesemann, Mila Jankovic, Jing H. Wang, John Manis, Andre Nussenzweig, Michel Nussenzweig, Frederick W. Alt

J Exp Med (2010) 207 (2): 417–427.

https://doi.org/10.1084/jem.20092449

Published: 08 February 2010

View article titled, Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Includes: Supplementary data

Journal Articles

A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

Tirtha Chakraborty, Thomas Perlot, Ramesh Subrahmanyam, Anant Jani, Peter H. Goff, Yu Zhang, Irina Ivanova, Frederick W. Alt, Ranjan Sen

J Exp Med (2009) 206 (5): 1019–1027.

https://doi.org/10.1084/jem.20081621

Published: 04 May 2009

View article titled, A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

Includes: Supplementary data

Journal Articles

Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

Dominik Schenten, Sven Kracker, Gloria Esposito, Sonia Franco, Ulf Klein, Michael Murphy, Frederick W. Alt, Klaus Rajewsky

J Exp Med (2009) 206 (2): 477–490.

https://doi.org/10.1084/jem.20080669

Published: 09 February 2009

View article titled, Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

Includes: Supplementary data

Journal Articles

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Jing H. Wang, Frederick W. Alt, Monica Gostissa, Abhishek Datta, Michael Murphy, Marat B. Alimzhanov, Kristen M. Coakley, Klaus Rajewsky, John P. Manis, Catherine T. Yan

J Exp Med (2008) 205 (13): 3079–3090.

https://doi.org/10.1084/jem.20082271

Published: 08 December 2008

View article titled, Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Includes: Supplementary data

Journal Articles

AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development

Makiko Takizawa, Helena Tolarová, Zhiyu Li, Wendy Dubois, Susan Lim, Elsa Callen, Sonia Franco, Maria Mosaico, Lionel Feigenbaum, Frederick W. Alt, André Nussenzweig, Michael Potter, Rafael Casellas

J Exp Med (2008) 205 (9): 1949–1957.

https://doi.org/10.1084/jem.20081007

Published: 04 August 2008

View article titled, AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development

Includes: Supplementary data

Journal Articles

Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching

Ali A. Zarrin, Peter H. Goff, Kate Senger, Frederick W. Alt

J Exp Med (2008) 205 (7): 1567–1572.

https://doi.org/10.1084/jem.20080451

Published: 09 June 2008

View article titled, Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching

Includes: Supplementary data

Journal Articles

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

Sonia Franco, Michael M. Murphy, Gang Li, Tiffany Borjeson, Cristian Boboila, Frederick W. Alt

J Exp Med (2008) 205 (3): 557–564.

https://doi.org/10.1084/jem.20080044

Published: 03 March 2008

View article titled, DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

Includes: Supplementary data

Journal Articles

Correction

Iannis Aifantis, Craig H. Bassing, Annette I. Garbe, Katie Sawai, Frederick W. Alt, Harald von Boehmer

J Exp Med (2006) 203 (7): 1831.

https://doi.org/10.1084/jem.20051711060606c

Published: 12 June 2006

View article titled, Correction

Journal Articles

The Eδ enhancer controls the generation of CD4⁻CD8⁻ αβTCR-expressing T cells that can give rise to different lineages of αβ T cells

Iannis Aifantis, Craig H. Bassing, Annette I. Garbe, Katie Sawai, Frederick W. Alt, Harald von Boehmer

J Exp Med (2006) 203 (6): 1543–1550.

https://doi.org/10.1084/jem.20051711

Published: 05 June 2006

View article titled, The Eδ enhancer controls the generation of CD4−CD8− αβTCR-expressing T cells that can give rise to different lineages of αβ T cells

Journal Articles

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

Keiko Fujikawa, Ana V. Miletic, Frederick W. Alt, Roberta Faccio, Tracie Brown, Jeremy Hoog, Jessica Fredericks, Shinzo Nishi, Shirly Mildiner, Sheri L. Moores, Joan Brugge, Fred S. Rosen, Wojciech Swat

J Exp Med (2003) 198 (10): 1595–1608.

https://doi.org/10.1084/jem.20030874

Published: 17 November 2003

View article titled, Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

Includes: Supplementary data

Journal Articles

Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

Darryll D. Dudley, JoAnn Sekiguchi, Chengming Zhu, Moshe J. Sadofsky, Scott Whitlow, Jeffrey DeVido, Robert J. Monroe, Craig H. Bassing, Frederick W. Alt

J Exp Med (2003) 198 (9): 1439–1450.

https://doi.org/10.1084/jem.20030627

Published: 27 October 2003

View article titled, Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

Includes: Supplementary data

Journal Articles

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer

Thomas Enzler, Silke Gillessen, John P. Manis, David Ferguson, James Fleming, Frederick W. Alt, Martin Mihm, Glenn Dranoff

J Exp Med (2003) 197 (9): 1213–1219.

https://doi.org/10.1084/jem.20021258

Published: 05 May 2003

View article titled, Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer

Includes: Supplementary data

Journal Articles

Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells

Sean Rooney, Frederick W. Alt, David Lombard, Scott Whitlow, Mark Eckersdorff, James Fleming, Sebastian Fugmann, David O. Ferguson, David G. Schatz, JoAnn, JoAnn Sekiguchi

J Exp Med (2003) 197 (5): 553–565.

https://doi.org/10.1084/jem.20021891

Published: 03 March 2003

View article titled, Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells

Includes: Supplementary data

NARROW

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development

Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

Correction

The Eδ enhancer controls the generation of CD4⁻CD8⁻ αβTCR-expressing T cells that can give rise to different lineages of αβ T cells

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer

Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells

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