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Journal Articles

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

D Pende, R Biassoni, C Cantoni, S Verdiani, M Falco, C di Donato, L Accame, C Bottino, A Moretta, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1996) 184 (2): 505–518.
https://doi.org/10.1084/jem.184.2.505
Published: 01 August 1996
View articletitled, The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.
Open the PDF for The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. in another window
Journal Articles

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

R Biassoni, C Cantoni, M Falco, S Verdiani, C Bottino, M Vitale, R Conte, A Poggi, A Moretta, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1996) 183 (2): 645–650.
https://doi.org/10.1084/jem.183.2.645
Published: 01 February 1996
View articletitled, The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.
Open the PDF for The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. in another window
Journal Articles

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

A Moretta, S Sivori, M Vitale, D Pende, L Morelli, R Augugliaro, C Bottino, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1995) 182 (3): 875–884.
https://doi.org/10.1084/jem.182.3.875
Published: 01 September 1995
View articletitled, Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.
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Journal Articles

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.

A Moretta, M Vitale, S Sivori, C Bottino, L Morelli, R Augugliaro, M Barbaresi, D Pende, E Ciccone, M Lopez-Botet, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1994) 180 (2): 545–555.
https://doi.org/10.1084/jem.180.2.545
Published: 01 August 1994
View articletitled, Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.
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Journal Articles

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

A Moretta, M Vitale, C Bottino, A M Orengo, L Morelli, R Augugliaro, M Barbaresi, E Ciccone, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1993) 178 (2): 597–604.
https://doi.org/10.1084/jem.178.2.597
Published: 01 August 1993
View articletitled, P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.
Open the PDF for P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. in another window
Journal Articles

CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta.

A Moretta, A Poggi, D Pende, G Tripodi, A M Orengo, N Pella, R Augugliaro, C Bottino, E Ciccone, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1991) 174 (6): 1393–1398.
https://doi.org/10.1084/jem.174.6.1393
Published: 01 December 1991
View articletitled, CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta.
Open the PDF for CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta. in another window
Journal Articles

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

A Moretta, C Bottino, D Pende, G Tripodi, G Tambussi, O Viale, A Orengo, M Barbaresi, A Merli, E Ciccone
Journal: Journal of Experimental Medicine
J Exp Med (1990) 172 (6): 1589–1598.
https://doi.org/10.1084/jem.172.6.1589
Published: 01 December 1990
View articletitled, Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.
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Journal Articles

A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function.

A Moretta, G Tambussi, C Bottino, G Tripodi, A Merli, E Ciccone, G Pantaleo, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1990) 171 (3): 695–714.
https://doi.org/10.1084/jem.171.3.695
Published: 01 March 1990
View articletitled, A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function.
Open the PDF for A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function. in another window
Journal Articles

Human peripheral blood lymphocytes bearing T cell receptor gamma/delta. Expression of CD8 differentiation antigen correlates with the expression of the 55-kD, C gamma 2-encoded gamma chain.

A Moretta, C Bottino, E Ciccone, G Tambussi, M C Mingari, S Ferrini, G Casorati, P Varese, O Viale, N Migone
Journal: Journal of Experimental Medicine
J Exp Med (1988) 168 (6): 2349–2354.
https://doi.org/10.1084/jem.168.6.2349
Published: 01 December 1988
View articletitled, Human peripheral blood lymphocytes bearing T cell receptor gamma/delta. Expression of CD8 differentiation antigen correlates with the expression of the 55-kD, C gamma 2-encoded gamma chain.
Open the PDF for Human peripheral blood lymphocytes bearing T cell receptor gamma/delta. Expression of CD8 differentiation antigen correlates with the expression of the 55-kD, C gamma 2-encoded gamma chain. in another window
Journal Articles

Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor.

C Bottino, G Tambussi, S Ferrini, E Ciccone, P Varese, M C Mingari, L Moretta, A Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1988) 168 (2): 491–505.
https://doi.org/10.1084/jem.168.2.491
Published: 01 August 1988
View articletitled, Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor.
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Journal Articles

A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s).

E Ciccone, S Ferrini, C Bottino, O Viale, I Prigione, G Pantaleo, G Tambussi, A Moretta, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1988) 168 (1): 1–11.
https://doi.org/10.1084/jem.168.1.1
Published: 01 July 1988
View articletitled, A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s).
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Journal Articles

Human cytolytic cell clones lacking surface expression of T cell receptor alpha/beta or gamma/delta. Evidence that surface structures other than CD3 or CD2 molecules are required for signal transduction.

G Pantaleo, M R Zocchi, S Ferrini, A Poggi, G Tambussi, C Bottino, L Moretta, A Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1988) 168 (1): 13–24.
https://doi.org/10.1084/jem.168.1.13
Published: 01 July 1988
View articletitled, Human cytolytic cell clones lacking surface expression of T cell receptor alpha/beta or gamma/delta. Evidence that surface structures other than CD3 or CD2 molecules are required for signal transduction.
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Journal Articles

Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture.

E Ciccone, O Viale, C Bottino, D Pende, N Migone, G Casorati, G Tambussi, A Moretta, L Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1988) 167 (4): 1517–1522.
https://doi.org/10.1084/jem.167.4.1517
Published: 01 April 1988
View articletitled, Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture.
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Journal Articles

A novel 120-kD surface antigen expressed by a subset of human lymphocytes. Evidence that lymphokine-activated killer cells express this molecule and use it in their effector function.

M R Zocchi, C Bottino, S Ferrini, L Moretta, A Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1987) 166 (2): 319–326.
https://doi.org/10.1084/jem.166.2.319
Published: 01 August 1987
View articletitled, A novel 120-kD surface antigen expressed by a subset of human lymphocytes. Evidence that lymphokine-activated killer cells express this molecule and use it in their effector function.
Open the PDF for A novel 120-kD surface antigen expressed by a subset of human lymphocytes. Evidence that lymphokine-activated killer cells express this molecule and use it in their effector function. in another window
Journal Articles

Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery.

S Ferrini, C Bottino, R Biassoni, A Poggi, R P Sekaly, L Moretta, A Moretta
Journal: Journal of Experimental Medicine
J Exp Med (1987) 166 (1): 277–282.
https://doi.org/10.1084/jem.166.1.277
Published: 01 July 1987
View articletitled, Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery.
Open the PDF for Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery. in another window