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Alexander N.R. Weber
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Journal Articles

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

In Special Collection:
Pattern Recognition Receptors and Beyond
Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert E. Hughes, Rusty Montgomery, Claudia P. Portillo, Paul Rubin, Taiz Salazar, Yan Wang, Shijun Yan, Barry A. Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V. Hochheiser, Hannes Buthmann, Dominic Ferber, Jane Torp, Wei Wang, Melanie Cranston, Chloe M. McKee, Thea J. Mawhinney, Emma C. McKay, Fehime K. Eroglu, Jasmin Kümmerle-Deschner, Alexander N.R. Weber, Bénédicte F. Py, Matthias Geyer, Rebecca C. Coll
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20242403.
https://doi.org/10.1084/jem.20242403
Published: 02 September 2025
View article titled, Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action
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Includes: Supplementary data
Journal Articles

Cracking the NLRP3 code: Pioneering precision medicine for inflammation

Alexander N.R. Weber, Maria Mateo Tortola, Jasmin B. Kuemmerle-Deschner
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20240221.
https://doi.org/10.1084/jem.20240221
Published: 27 March 2024
View article titled, Cracking the NLRP3 code: Pioneering precision medicine for inflammation
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Journal Articles

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

In Special Collection:
The Inflammasomes: From Mechanism to Therapeutics
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (11): e20201656.
https://doi.org/10.1084/jem.20201656
Published: 23 September 2021
View article titled, BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Open the PDF for BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity in another window
Includes: Supplementary data