The authors report the transcriptome of mouse retinal pigment epithelium/choroid tissue at single-cell resolution. A subset of choroidal endothelial cells expresses Indian Hedgehog, which targets mesenchymal stem cell–like cells regulating mast cell survival and the inflammatory response after damage.
Using an in vivo real-time approach, the authors show that local myeloid cells remove early CNS-invading T cells via an engulfment pathway that is dependent on N-acetyl-D-glucosamine (GlcNAc) and lectin. These results reveal a novel capacity of myeloid cells to counteract neuroinflammation.
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function
Human lung tumors engage in substantial mitochondrial metabolism. Here, Ward et al. demonstrate that nicotinamide nucleotide transhydrogenase (NNT) supports oxidative metabolism in NSCLC by mitigating Fe-S cluster oxidation.
Brief Definitive Report
This study unravels an unprecedented murine model of lethal metastatic prostate cancer, based on the combined deletion of Pten and Lkb1. Importantly, minimal activity of LKB1 is sufficient to hamper prostate cancer cell aggressiveness, thus redefining the relationship between gene dosage and tumor suppression.
Dominant-negative variants of STAT3 do not account for all cases of autosomal dominant hyper-IgE syndrome (HIES). Béziat et al. report HIES patients with dominant-negative variations of IL6ST, encoding the GP130 receptor, which normally recruits STAT3 upon stimulation with IL-6 and related cytokines.