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Issues

ISSN 0022-1007
EISSN 1540-9538
In this Issue

Insights

Brief Definitive Report

Healthy, uninfected individuals harbor HIV-specific naive and memory CD4+ T cells, and many memory T cell epitopes are similar in sequence to peptides expressed by natural commensal bacteria, suggesting potential cross-reactivity.

Rapid eosinophil accumulation around nematode species occurs via leukotriene induction, which is necessary for nematode-induced eosinophil accumulation in the lung.

NK cells lacking proapoptotic factor Bim show impaired contraction phase after MCMV infection, leading to impaired memory cell maturation and a less effective responses to viral rechallenge.

S1PR2 and CXCR5 cooperatively regulate localization of Tfh cells in GCs to support GC responses.

Adherent neutrophils responding to chemoattractants release TNF in proximity of endothelial cell junctions to mediate microvascular leakage.

Article

Fdg5 identifies bone marrow cells with potent hematopoietic stem cell activity.

Independent of its known role in NF-κB transcription, the HOIL-1L containing LUBAC is required for assembly and activation of the NLRP3 inflammasome via linear ubiquitination of ASC.

First case of a human RASGRP2 mutation affecting Rap1 activation in platelets and causing severe bleeding.

CD1c self-reactive T cells recognize a novel class of self-lipids that are accumulated on leukemia cells.

CDK4 activation/RB phosphorylation occurs in 50% of indolent but high-risk follicular lymphomas and implies susceptibility to dual CDK4 and BCL2 inhibition.

IFN-γ directly triggers degranulation and death of Paneth cells, which do not respond to microbial stimulation in primary culture.

DOCK5 is a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation.

Lymphotoxin expressed by RORγt+ innate lymphoid cells is critical for natural killer cell development.

Agonistic anti–4-1BB suppresses autoimmune and allergic inflammation via binding to Galectin-9, which facilitates 4-1BB aggregation, signaling, and functional activity.

IL-17A stimulates cardiac fibroblasts to produce inflammatory mediators critical for the recruitment and differentiation of myeloid cells during inflammatory dilated cardiomyopathy.

Human myelin oligodendrocyte glycoprotein is decorated with fucosylated N-glycans that are recognized by DC-SIGN+ DCs and microglia that control immune homeostasis.

β2 Integrin–mediated systemic release of neutrophil extracellular traps is a novel mechanism of immunopathology associated with hantavirus infection.

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