ON THE COVER
The mucin Muc5ac is essential for the expulsion of Trichuris muris and other gut-dwelling nematodes. The image shows mucus-producing goblet cells (fuchsia) in the intestine. Artwork by Rachel Urkowitz (firstname.lastname@example.org).
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Brief Definitive Report
By transactivating expression of miRNAs that repress expression of the ZEB1 and ZEB2 transcription factors, p53 inhibits the epithelial–mesenchymal transition.
Langerhans cells suppress the immune response to low-dose Leishmania major infection in part by inducing regulatory T cells.
The mucin Muc5ac is essential for the expulsion of Trichuris muris and other gut-dwelling nematodes.
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
IL7R-activating mutations identified in B-ALL and T-ALL patient leukemic cells facilitate cytokine-independent growth.
Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion
Trypanosoma cruzi takes advantage of a sphingomyelinase-dependent plasma membrane repair pathway to gain access to host cells.
HSCs lacking the guanosine nucleotide-binding protein Gimap5, which stabilizes expression of the Mcl-1 Bcl2 family protein, exhibit impaired survival and long-term repopulation capacity.
Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain
Inducible alterations in expression of cyclinD1 and cdk4 in the adult mouse hippocampus allow temporal control and manipulation of neurogenesis.
Newly identified tissue-resident vascular precursor cells are recruited into growing vessels and contribute to vasculogenesis in adult mice.
Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
A monoclonal anti-CD160 antibody inhibits the growth of new vessels in pathological ocular and tumor neoangiogenesis but not in healthy tissues.
T-bet acts as a functional repressor in association with Bcl-6 to antagonize SOCS1, SOCS3, TCF-1, and late-stage IFN-γ to regulate Th1 development.
Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses
Homing of conventional T cells to NALT is primarily dependent on L-selectin–PNAd interactions, whereas homing of regulatory T cells also depends on PSGL1- and CD44-mediated adhesion.
Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology
Interleukin-10 acts directly on CD45RBlo but not CD45RBhi cells to control colitis upon transfer into Rag1-deficient recipients.
N-linked glycans on class II MHC molecules are required for the presentation of glycoantigens, but not peptide antigens.
Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity
By dynamically remodeling the cortical actin network, ezrin and moesin control BCR microcluster formation, organization, and integrity.
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
Host macrophages protect against graft-versus-host disease in part by engulfing donor T cells and inhibiting their proliferation.
By engaging CD36 on murine macrophages, thrombospondin-1 prevents excessive macrophage VEGF-C production and corneal neovascularization.
KLF13 sustains thymic memory-like CD8+ T cells in BALB/c mice by regulating IL-4–generating invariant natural killer T cells
Transcription factor KLF13 regulates the elevated numbers of iNKT cells in the BALB/c versus C57BL/6 thymus that results in production of sufficient levels of IL-4 to generate memory-like CD8+ T cells.
Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
MCMV-infected cells are recognized by multiple MHC class I–restricted Ly49-activating receptors in genetically distinct mouse strains.