ON THE COVER
Argonaute 2 (Ago2) is involved in the generation of certain miRNAs and in miRNA-mediated gene silencing. Schaefer et al. find that ablation of Ago2 in dopamine 2 receptor–expressing medium spiny neurons alleviates cocaine addiction in mice. The pseudocolored image depicts normal morphology of medium spiny neurons in the brains of mice lacking Ago2 in these cells. Artwork by Joshua Graver (email@example.com).
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Brief Definitive Report
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation