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2 August 2010
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Cover Image
ON THE COVER
miRNA-21 expression increases in the lungs of patients with idiopathic pulmonary fibrosis and mice with bleomycin-induced fibrosis, according to Liu et al. Ablating miR-21 expression—even after disease onset— attenuated the severity of lung fibrosis in mice. The image depicts an abstraction of lung architecture free of fibrosis or inflammation after miR-21 ablation. Artwork by Rachel Urkowitz ([email protected]).
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ISSN 0022-1007
EISSN 1540-9538
In this Issue
Review
Brief Definitive Report
B cell depletion reduces the development of atherosclerosis in mice
Hafid Ait-Oufella,Olivier Herbin,Jean-David Bouaziz,Christoph J. Binder,Catherine Uyttenhove,Ludivine Laurans,Soraya Taleb,Emily Van Vré,Bruno Esposito,José Vilar,Jérôme Sirvent,Jacques Van Snick,Alain Tedgui,Thomas F. Tedder,Ziad Mallat
Peroxisome proliferator–activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity
Shannon E. Dunn,Roopa Bhat,Daniel S. Straus,Raymond A. Sobel,Robert Axtell,Amanda Johnson,Kim Nguyen,Lata Mukundan,Marina Moshkova,Jason C. Dugas,Ajay Chawla,Lawrence Steinman
Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis
Andrea Cruz,Alexandra G. Fraga,Jeffrey J. Fountain,Javier Rangel-Moreno,Egídio Torrado,Margarida Saraiva,Daniela R. Pereira,Troy D. Randall,Jorge Pedrosa,Andrea M. Cooper,António G. Castro
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
Athena Chalaris,Nina Adam,Christian Sina,Philip Rosenstiel,Judith Lehmann-Koch,Peter Schirmacher,Dieter Hartmann,Joanna Cichy,Olga Gavrilova,Stefan Schreiber,Thomas Jostock,Vance Matthews,Robert Häsler,Christoph Becker,Markus F. Neurath,Karina Reiß,Paul Saftig,Jürgen Scheller,Stefan Rose-John
Article
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b
Shuning Zhang,Mike Rozell,Raj K. Verma,Diana I. Albu,Danielle Califano,Jeffrey VanValkenburgh,Akeel Merchant,Javier Rangel-Moreno,Troy D. Randall,Nancy A. Jenkins,Neal G. Copeland,Pentao Liu,Dorina Avram
Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity
Ravi S. Misra,Guixiu Shi,Miguel E. Moreno-Garcia,Anil Thankappan,Michael Tighe,Betty Mousseau,Kim Kusser,Shirly Becker-Herman,Kelly L. Hudkins,Robert Dunn,Marilyn R. Kehry,Thi-Sau Migone,Ann Marshak-Rothstein,Melvin Simon,Troy D. Randall,Charles E. Alpers,Denny Liggitt,David J. Rawlings,Frances E. Lund
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