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31 August 2009
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Cover Image
Cover Image
ON THE COVER
Photograph of balancing rocks by Heiko Brinkmann. Fluctuations in dendritic cell numbers cause reciprocal changes in T reg cells, thus helping to maintain homeostasis and prevent autoimmunity. Related article by Darasse-Jèze et al.
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ISSN 0022-1007
EISSN 1540-9538
In this Issue
In This Issue
People & Ideas
Ajit Varki: On the origin of maladies
Some say language makes us human, others say it's art or free will. Ajit Varki points out how our diseases set us apart from the apes.
Commentary
Brief Definitive Report
Article
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
Andrew M. Smith,Farooq Z. Rahman,Bu'Hussain Hayee,Simon J. Graham,Daniel J.B. Marks,Gavin W. Sewell,Christine D. Palmer,Jonathan Wilde,Brian M.J. Foxwell,Israel S. Gloger,Trevor Sweeting,Mark Marsh,Ann P. Walker,Stuart L. Bloom,Anthony W. Segal
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
Sarah M. McWhirter,Roman Barbalat,Kathryn M. Monroe,Mary F. Fontana,Mamoru Hyodo,Nathalie T. Joncker,Ken J. Ishii,Shizuo Akira,Marco Colonna,Zhijian J. Chen,Katherine A. Fitzgerald,Yoshihiro Hayakawa,Russell E. Vance
Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
Elaine Agius,Katie E. Lacy,Milica Vukmanovic-Stejic,Ann L. Jagger,Anna-Pia Papageorgiou,Sue Hall,John R. Reed,S. John Curnow,Judilyn Fuentes-Duculan,Christopher D. Buckley,Mike Salmon,Leonie S. Taams,James Krueger,John Greenwood,Nigel Klein,Malcolm H.A. Rustin,Arne N. Akbar
Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration
Rebekka Grundler,Laurent Brault,Christelle Gasser,Alex N. Bullock,Tobias Dechow,Sabine Woetzel,Vanda Pogacic,Antonello Villa,Sabine Ehret,Georgina Berridge,Anke Spoo,Christine Dierks,Andrea Biondi,Stefan Knapp,Justus Duyster,Juerg Schwaller
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
Matthew J. Robinson,Fabiola Osorio,Marcela Rosas,Rui P. Freitas,Edina Schweighoffer,Olaf Groß,J. Sjef Verbeek,Jürgen Ruland,Victor Tybulewicz,Gordon D. Brown,Luis Ferreira Moita,Philip R. Taylor,Caetano Reis e Sousa
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