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In This Issue

Pesticide-induced proliferation

Amy Maxmen
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Spying on antigen hand-offs

Amy Maxmen
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IL-17's tumor team

Amy Maxmen
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Healthy hearts lay off LOX

Amy Maxmen
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Mend that gut, STAT!

Amy Maxmen
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People & Ideas

HIV, prayer, and vintage cars: Danny Douek talks shop

Amy Maxmen

If a scientist is defined as a person who acquires knowledge methodologically, Douek fits the bill in every way.

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Brief Definitive Report

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

Lin Wang,Tangsheng Yi,Marcin Kortylewski,Drew M. Pardoll,Defu Zeng,Hua Yu
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Geethanjali Pickert,Clemens Neufert,Moritz Leppkes,Yan Zheng,Nadine Wittkopf,Moritz Warntjen,Hans-Anton Lehr,Sebastian Hirth,Benno Weigmann,Stefan Wirtz,Wenjun Ouyang,Markus F. Neurath,Christoph Becker
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Agricultural pesticide exposure and the molecular connection to lymphomagenesis

Julie Agopian,Jean-Marc Navarro,Anne-Claire Gac,Yannick Lecluse,Mélanie Briand,Pierre Grenot,Pascal Gauduchon,Philippe Ruminy,Pierre Lebailly,Bertrand Nadel,Sandrine Roulland
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Visualizing B cell capture of cognate antigen from follicular dendritic cells

Kazuhiro Suzuki,Irina Grigorova,Tri Giang Phan,Lisa M. Kelly,Jason G. Cyster
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The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

Cameron S. Brandt,Myriam Baratin,Eugene C. Yi,Jacob Kennedy,Zeren Gao,Brian Fox,Betty Haldeman,Craig D. Ostrander,Tomonori Kaifu,Christian Chabannon,Alessandro Moretta,Robert West,WenFeng Xu,Eric Vivier,Steven D. Levin
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The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

Christian Koble,Bruno Kyewski
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Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis

Divya Purushothaman,Apurva Sarin
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Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells

Rebekka Geiger,Thomas Duhen,Antonio Lanzavecchia,Federica Sallusto
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Article

Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression

John D. Campbell,Karen F. Buckland,Sarah J. McMillan,Jennifer Kearley,William L.G. Oldfield,Lawrence J. Stern,Hans Grönlund,Marianne van Hage,Catherine J. Reynolds,Rosemary J. Boyton,Stephen P. Cobbold,A. Barry Kay,Daniel M. Altmann,Clare M. Lloyd,Mark Larché
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T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

Yuhong Yang,Jeffrey Weiner,Yue Liu,Alan J. Smith,David J. Huss,Ryan Winger,Haiyan Peng,Petra D. Cravens,Michael K. Racke,Amy E. Lovett-Racke
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Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure

Yosuke Kayama,Tohru Minamino,Haruhiro Toko,Masaya Sakamoto,Ippei Shimizu,Hidehisa Takahashi,Sho Okada,Kaoru Tateno,Junji Moriya,Masataka Yokoyama,Aika Nojima,Michihiro Yoshimura,Kensuke Egashira,Hiroyuki Aburatani,Issei Komuro
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Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Afam Okoye,Haesun Park,Mukta Rohankhedkar,Lia Coyne-Johnson,Richard Lum,Joshua M. Walker,Shannon L. Planer,Alfred W. Legasse,Andrew W. Sylwester,Michael Piatak, Jr.,Jeffrey D. Lifson,Donald L. Sodora,Francois Villinger,Michael K. Axthelm,Joern E. Schmitz,Louis J. Picker
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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

M. Paula Longhi,Christine Trumpfheller,Juliana Idoyaga,Marina Caskey,Ines Matos,Courtney Kluger,Andres M. Salazar,Marco Colonna,Ralph M. Steinman
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Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Wei Cao,Laura Bover,Minkwon Cho,Xiaoxia Wen,Shino Hanabuchi,Musheng Bao,David B. Rosen,Yi-Hong Wang,Joanne L. Shaw,Qiumei Du,Chun Li,Naoko Arai,Zhengbin Yao,Lewis L. Lanier,Yong-Jun Liu
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A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice

James R. Conner,Irina I. Smirnova,Alexander Poltorak
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Correction

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

Sara González-García,Marina García-Peydró,Enrique Martín-Gayo,Esteban Ballestar,Manel Esteller,Rafael Bornstein,José Luis de la Pompa,Adolfo A. Ferrando,María L. Toribio
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Cholera toxin inhibits IL-12 production and CD8α+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

Andrea la Sala,Jianping He,Leopoldo Laricchia-Robbio,Stefania Gorini,Akiko Iwasaki,Michael Braun,George S. Yap,Alan Sher,Keiko Ozato,Brian Kelsall
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