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Issues

Volume 205, Issue 6
9 June 2008
Issue Cover
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  • Cover Image

    Cover Image

    issue cover

    ON THE COVER
    Image (provided by Pietro M. Motta and Tomonori Naguro / Photo Researchers, Inc) shows a colored high resolution scanning electron micrograph of two lysosomes in a pancreatic acinar cell. When the lysosomal membrane protein TRP-ML1 is mutated, the lysosome internalizes endosomal lipid cargo but fails to digest it, causing a lipid pile-up (top). Related story by Miedel et al.
    See page 1477

  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 0022-1007
EISSN 1540-9538

In This Issue

Gut-friendly B cells?
Hema Bashyam
View Articletitled, Gut-friendly B cells?
Balanced T cell subsets for good health
Hema Bashyam
View Articletitled, Balanced T cell subsets for good health
Retraining macrophages to kill tumors
Hema Bashyam
View Articletitled, Retraining macrophages to kill tumors
No exit strategy for lipids
Hema Bashyam
View Articletitled, No exit strategy for lipids
Endothelial cells instigate sepsis
Hema Bashyam
View Articletitled, Endothelial cells instigate sepsis

People & Ideas

Vamsi Mootha: Taking an inventory of mitochondria
Hema Bashyam
View Articletitled, Vamsi Mootha: Taking an inventory of mitochondria

Commentary

Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice
David Tarlinton
View Articletitled, Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice
IKKβ/NF-κB and the miscreant macrophage
Anjuli M. Timmer,Victor Nizet
View Articletitled, IKKβ/NF-κB and the miscreant macrophage

Brief Definitive Report

“Re-educating” tumor-associated macrophages by targeting NF-κB
Thorsten Hagemann,Toby Lawrence,Iain McNeish,Kellie A. Charles,Hagen Kulbe,Richard G. Thompson,Stephen C. Robinson,Frances R. Balkwill
View Articletitled, “Re-educating” tumor-associated macrophages by targeting NF-κB
An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation
Carol Ho Yan Fong,Magali Bebien,Arnaud Didierlaurent,Ruth Nebauer,Tracy Hussell,David Broide,Michael Karin,Toby Lawrence
View Articletitled, An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis
George Plitas,Bryan M. Burt,Hoang M. Nguyen,Zubin M. Bamboat,Ronald P. DeMatteo
View Articletitled, Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis
Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
Elizabeth Rose Walsh,Nisebita Sahu,Jennifer Kearley,Ebony Benjamin,Boo Hyon Kang,Alison Humbles,Avery August
View Articletitled, Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8
Jan Kranich,Nike Julia Krautler,Ernst Heinen,Magdalini Polymenidou,Claire Bridel,Anita Schildknecht,Christoph Huber,Marie H. Kosco-Vilbois,Rolf Zinkernagel,Gino Miele,Adriano Aguzzi
View Articletitled, Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

Article

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis
Xiaobing Ye,Jianqiang Ding,Xiaozhou Zhou,Guoqian Chen,Shu Fang Liu
View Articletitled, Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis
Cornelia Hömig-Hölzel,Caroline Hojer,Julia Rastelli,Stefano Casola,Lothar J. Strobl,Werner Müller,Leticia Quintanilla-Martinez,Andreas Gewies,Jürgen Ruland,Klaus Rajewsky,Ursula Zimber-Strobl
View Articletitled, Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis
Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infants
Sandra Weller,Maria Mamani-Matsuda,Capucine Picard,Corinne Cordier,Damiana Lecoeuche,Frédéric Gauthier,Jean-Claude Weill,Claude-Agnès Reynaud
View Articletitled, Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM<sup>+</sup>IgD<sup>+</sup>CD27<sup>+</sup> B cell repertoire in infants
A unique B2 B cell subset in the intestine
Yasuyo Shimomura,Atsuhiro Ogawa,Mayumi Kawada,Ken Sugimoto,Emiko Mizoguchi,Hai-Ning Shi,Shiv Pillai,Atul K. Bhan,Atsushi Mizoguchi
View Articletitled, A unique B2 B cell subset in the intestine
Proteasomal degradation restricts the nuclear lifespan of AID
Said Aoufouchi,Ahmad Faili,Carole Zober,Orietta D'Orlando,Sandra Weller,Jean-Claude Weill,Claude-Agnès Reynaud
View Articletitled, Proteasomal degradation restricts the nuclear lifespan of AID
Development and characterization of IL-21–producing CD4+ T cells
Akira Suto,Daisuke Kashiwakuma,Shin-ichiro Kagami,Koichi Hirose,Norihiko Watanabe,Kotaro Yokote,Yasushi Saito,Toshinori Nakayama,Michael J. Grusby,Itsuo Iwamoto,Hiroshi Nakajima
View Articletitled, Development and characterization of IL-21–producing CD4<sup>+</sup> T cells
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
Matthias Lochner,Lucie Peduto,Marie Cherrier,Shinichiro Sawa,Francina Langa,Rosa Varona,Dieter Riethmacher,Mustapha Si-Tahar,James P. Di Santo,Gérard Eberl
View Articletitled, In vivo equilibrium of proinflammatory IL-17<sup>+</sup> and regulatory IL-10<sup>+</sup> Foxp3<sup>+</sup> RORγt<sup>+</sup> T cells
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
Benjamin J. Thompson,Vladimir Jankovic,Jie Gao,Silvia Buonamici,Alan Vest,Jennifer May Lee,Jiri Zavadil,Stephen D. Nimer,Iannis Aifantis
View Articletitled, Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
Martin Holdener,Edith Hintermann,Monika Bayer,Antje Rhode,Evelyn Rodrigo,Gudrun Hintereder,Eric F. Johnson,Frank J. Gonzalez,Josef Pfeilschifter,Michael P. Manns,Matthias von G. Herrath,Urs Christen
View Articletitled, Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies
Maria Jose Uria,Qian Zhang,Yanwen Li,Angel Chan,Rachel M. Exley,Bridget Gollan,Hannah Chan,Ian Feavers,Andy Yarwood,Raquel Abad,Ray Borrow,Roland A. Fleck,Barbara Mulloy,Julio A. Vazquez,Christoph M. Tang
View Articletitled, A generic mechanism in <em>Neisseria meningitidis</em> for enhanced resistance against bactericidal antibodies
Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
David Frommhold,Andreas Ludwig,M. Gabriele Bixel,Alexander Zarbock,Inna Babushkina,Melitta Weissinger,Sandra Cauwenberghs,Lesley G. Ellies,Jamey D. Marth,Annette G. Beck-Sickinger,Michael Sixt,Bärbel Lange-Sperandio,Alma Zernecke,Ernst Brandt,Christian Weber,Dietmar Vestweber,Klaus Ley,Markus Sperandio
View Articletitled, Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
Franca Gerosa,Barbara Baldani-Guerra,Lyudmila A. Lyakh,Giovanna Batoni,Semih Esin,Robin T. Winkler-Pickett,Maria Rita Consolaro,Mario De Marchi,Daniela Giachino,Angela Robbiano,Marco Astegiano,Angela Sambataro,Robert A. Kastelein,Giuseppe Carra,Giorgio Trinchieri
View Articletitled, Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
A crucial role for HVEM and BTLA in preventing intestinal inflammation
Marcos W. Steinberg,Olga Turovskaya,Raziya B. Shaikh,Gisen Kim,Declan F. McCole,Klaus Pfeffer,Kenneth M. Murphy,Carl F. Ware,Mitchell Kronenberg
View Articletitled, A crucial role for HVEM and BTLA in preventing intestinal inflammation
Membrane traffic and turnover in TRP-ML1–deficient cells: a revised model for mucolipidosis type IV pathogenesis
Mark T. Miedel,Youssef Rbaibi,Christopher J. Guerriero,Grace Colletti,Kelly M. Weixel,Ora A. Weisz,Kirill Kiselyov
View Articletitled, Membrane traffic and turnover in TRP-ML1–deficient cells: a revised model for mucolipidosis type IV pathogenesis
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling
Wangsen Cao,Clare Bao,Elizaveta Padalko,Charles J. Lowenstein
View Articletitled, Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

Correction

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
Silvia Piconese,Barbara Valzasina,Mario P. Colombo
View Articletitled, OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
Chang Hoon Lee,Mark Melchers,Hongsheng Wang,Ted A. Torrey,Rebecca Slota,Chen-Feng Qi,Ji Young Kim,Patricia Lugar,Hee Jeong Kong,Lila Farrington,Boris van der Zouwen,Jeff X. Zhou,Vassilios Lougaris,Peter E. Lipsky,Amrie C. Grammer,Herbert C. Morse, III
View Articletitled, Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis
Xiaobing Ye,Jianqiang Ding,Xiaozhou Zhou,Guoqian Chen,Shu Fang Liu
View Articletitled, Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

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