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A Reply from HHMI

Tom Cech,Jack Dixon,Avice Meehan,Josie Briggs,Carl Rhodes
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Oral tolerance: is it all retinoic acid?

Harald von Boehmer
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Response to HHMI from Mike Rossner (Executive Director, The Rockefeller University Press) and Ira Mellman (Editor in Chief, the Journal of Cell Biology):

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In This Issue

How inflammation signals heart trouble

Hema Bashyam
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EBV covers its tracks

Hema Bashyam
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CpGs relieve arthritis

Hema Bashyam
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All B cells need is BAFF

Hema Bashyam
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New mutations stabilize NOTCH1

Hema Bashyam
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From the Archive

Receptor editing: How B cells stay tolerant

Hema Bashyam
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Brief Definitive Report

Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia

Changlian Zhu,Xiaoyang Wang,Johanna Deinum,Zhiheng Huang,Jianfeng Gao,Nazanine Modjtahedi,Martha R. Neagu,Michael Nilsson,Peter S. Eriksson,Henrik Hagberg,Jeremy Luban,Guido Kroemer,Klas Blomgren
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Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer

Yoshinori Naoe,Ruka Setoguchi,Kaori Akiyama,Sawako Muroi,Masahiko Kuroda,Farah Hatam,Dan R. Littman,Ichiro Taniuchi
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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Janine L. Coombes,Karima R.R. Siddiqui,Carolina V. Arancibia-Cárcamo,Jason Hall,Cheng-Ming Sun,Yasmine Belkaid,Fiona Powrie
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All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

Micah J. Benson,Karina Pino-Lagos,Mario Rosemblatt,Randolph J. Noelle
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Article

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Cheng-Ming Sun,Jason A. Hall,Rebecca B. Blank,Nicolas Bouladoux,Mohamed Oukka,J. Rodrigo Mora,Yasmine Belkaid
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An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

Jae-Ho Cho,Onur Boyman,Hee-Ok Kim,Bumsuk Hahm,Mark P. Rubinstein,Chris Ramsey,David M. Kim,Charles D. Surh,Jonathan Sprent
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Naive CD8+ T cells differentiate into protective memory-like cells after IL-2–anti–IL-2 complex treatment in vivo

Daisuke Kamimura,Michael J. Bevan
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Jennifer O'Neil,Jonathan Grim,Peter Strack,Sudhir Rao,Deanne Tibbitts,Christopher Winter,James Hardwick,Markus Welcker,Jules P. Meijerink,Rob Pieters,Giulio Draetta,Rosalie Sears,Bruce E. Clurman,A. Thomas Look
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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

Benjamin J. Thompson,Silvia Buonamici,Maria Luisa Sulis,Teresa Palomero,Tomas Vilimas,Giuseppe Basso,Adolfo Ferrando,Iannis Aifantis
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IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cells

Yui-Hsi Wang,Pornpimon Angkasekwinai,Ning Lu,Kui Shin Voo,Kazuhiko Arima,Shino Hanabuchi,Andreas Hippe,Chris J. Corrigan,Chen Dong,Bernhard Homey,Zhengbin Yao,Sun Ying,David P. Huston,Yong-Jun Liu
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Phenotypic and functional features of human Th17 cells

Francesco Annunziato,Lorenzo Cosmi,Veronica Santarlasci,Laura Maggi,Francesco Liotta,Benedetta Mazzinghi,Eliana Parente,Lucia Filì,Simona Ferri,Francesca Frosali,Francesco Giudici,Paola Romagnani,Paola Parronchi,Francesco Tonelli,Enrico Maggi,Sergio Romagnani
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A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

Andrew D. Hislop,Maaike E. Ressing,Daphne van Leeuwen,Victoria A. Pudney,Daniëlle Horst,Danijela Koppers-Lalic,Nathan P. Croft,Jacques J. Neefjes,Alan B. Rickinson,Emmanuel J.H.J. Wiertz
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Signaling through FcγRIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation

Hozefa S. Bandukwala,Bryan S. Clay,Jiankun Tong,Purvi D. Mody,Judy L. Cannon,Rebecca A. Shilling,J. Sjef Verbeek,Joel V. Weinstock,Julian Solway,Anne I. Sperling
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MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection

Katharina Brandl,George Plitas,Bernd Schnabl,Ronald P. DeMatteo,Eric G. Pamer
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The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection

Charaf Benarafa,Gregory P. Priebe,Eileen Remold-O'Donnell
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Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk

Hsin-Jung Wu,Heloisa Sawaya,Bryce Binstadt,Margot Brickelmaier,Amanda Blasius,Leonid Gorelik,Umar Mahmood,Ralph Weissleder,John Carulli,Christophe Benoist,Diane Mathis
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Organ-dependent in vivo priming of naive CD4+,but not CD8+,T cells by plasmacytoid dendritic cells

Anita Sapoznikov,Jens A.A. Fischer,Tami Zaft,Rita Krauthgamer,Andrzej Dzionek,Steffen Jung
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Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man

Maren Luchtefeld,Heribert Schunkert,Monika Stoll,Tina Selle,Rachel Lorier,Karsten Grote,Christian Sagebiel,Kumaravelu Jagavelu,Uwe J.F. Tietge,Ulrike Assmus,Konrad Streetz,Christian Hengstenberg,Marcus Fischer,Björn Mayer,Karen Maresso,Nour Eddine El Mokhtari,Stefan Schreiber,Werner Müller,Udo Bavendiek,Christina Grothusen,Helmut Drexler,Christian Trautwein,Ulrich Broeckel,Bernhard Schieffer
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The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

Takeshi Egawa,Robert E. Tillman,Yoshinori Naoe,Ichiro Taniuchi,Dan R. Littman
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BAFF and MyD88 signals promote a lupuslike disease independent of T cells

Joanna R. Groom,Carrie A. Fletcher,Stacey N. Walters,Shane T. Grey,Sally V. Watt,Mathew J. Sweet,Mark J. Smyth,Charles R. Mackay,Fabienne Mackay
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Human hepatic stem cells from fetal and postnatal donors

Eva Schmelzer,Lili Zhang,Andrew Bruce,Eliane Wauthier,John Ludlow,Hsin-lei Yao,Nicholas Moss,Alaa Melhem,Randall McClelland,William Turner,Michael Kulik,Sonya Sherwood,Tommi Tallheden,Nancy Cheng,Mark E. Furth,Lola M. Reid
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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

Petra Langerak,Anders O.H. Nygren,Peter H.L. Krijger,Paul C.M. van den Berk,Heinz Jacobs
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Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

Justin Paul,Sidney Strickland,Jerry P. Melchor
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