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In This Issue

Two strikes lead to leukemia

Heather L. Van Epps
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Defenseless against the common cold

Heather L. Van Epps
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Too old to help

Heather L. Van Epps
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Clean living staves off autoimmunity

Heather L. Van Epps
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Commentary

Signaling for NKT cell development : the SAP–FynT connection

Christine Borowski,Albert Bendelac
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T cell aging : naive but not young

Janko Nikolich-Žugich
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Identifying genes that regulate bone remodeling as potential therapeutic targets

Stephen M. Krane
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Brief Definitive Report

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

Laura Haynes,Sheri M. Eaton,Eve M. Burns,Troy D. Randall,Susan L. Swain
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Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells

Tamiko R. Katsumoto,Jennifer Duda,Andrew Kim,Zabihullah Wardak,Glenn Dranoff,D. Wade Clapp,Kevin Shannon
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Article

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α

Junko Sasaki,Takehiko Sasaki,Masakazu Yamazaki,Kunie Matsuoka,Choji Taya,Hiroshi Shitara,Shunsuke Takasuga,Miki Nishio,Katsunori Mizuno,Teiji Wada,Hideyuki Miyazaki,Hiroshi Watanabe,Ryota Iizuka,Shuichi Kubo,Shigeo Murata,Tomoki Chiba,Tomohiko Maehama,Koichi Hamada,Hiroyuki Kishimoto,Michael A. Frohman,Keiji Tanaka,Josef M. Penninger,Hiromichi Yonekawa,Akira Suzuki,Yasunori Kanaho
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Platelet activation leads to activation and propagation of the complement system

Ian del Conde,Miguel A. Crúz,Hui Zhang,José A. López,Vahid Afshar-Kharghan
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A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia–like syndrome in BXH-2 mice

Karine Turcotte,Susan Gauthier,Ashleigh Tuite,Alaka Mullick,Danielle Malo,Philippe Gros
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Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

Alasdair Leslie,Daniel Kavanagh,Isobella Honeyborne,Katja Pfafferott,Charles Edwards,Tilly Pillay,Louise Hilton,Christina Thobakgale,Danni Ramduth,Rika Draenert,Sylvie Le Gall,Graz Luzzi,Anne Edwards,Christian Brander,Andrew K. Sewell,Sarah Moore,James Mullins,Corey Moore,Simon Mallal,Nina Bhardwaj,Karina Yusim,Rodney Phillips,Paul Klenerman,Bette Korber,Photini Kiepiela,Bruce Walker,Philip Goulder
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CD44 is a determinant of inflammatory bone loss

Silvia Hayer,Günter Steiner,Birgit Görtz,Erika Reiter,Makiyeh Tohidast-Akrad,Michael Amling,Oskar Hoffmann,Kurt Redlich,Jochen Zwerina,Karl Skriner,Frank Hilberg,Erwin F. Wagner,Josef S. Smolen,Georg Schett
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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

Satoshi Uematsu,Shintaro Sato,Masahiro Yamamoto,Tomonori Hirotani,Hiroki Kato,Fumihiko Takeshita,Michiyuki Matsuda,Cevayir Coban,Ken J. Ishii,Taro Kawai,Osamu Takeuchi,Shizuo Akira
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Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis

Amir Abdollahi,Minglun Li,Gong Ping,Christian Plathow,Sophie Domhan,Fabian Kiessling,Leslie B. Lee,Gerald McMahon,Hermann-Josef Gröne,Kenneth E. Lipson,Peter E. Huber
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Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

Peter A.B. Wark,Sebastian L. Johnston,Fabio Bucchieri,Robert Powell,Sarah Puddicombe,Vasile Laza-Stanca,Stephen T. Holgate,Donna E. Davies
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A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Hiroyuki Yoshitomi,Noriko Sakaguchi,Katsuya Kobayashi,Gordon D. Brown,Tomoyuki Tagami,Toshiko Sakihama,Keiji Hirota,Satoshi Tanaka,Takashi Nomura,Ichiro Miki,Siamon Gordon,Shizuo Akira,Takashi Nakamura,Shimon Sakaguchi
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The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein–induced bone formation

Mikihiko Morinobu,Tetsuya Nakamoto,Kazunori Hino,Kunikazu Tsuji,Zhong-Jian Shen,Kazuhisa Nakashima,Akira Nifuji,Haruyasu Yamamoto,Hisamaru Hirai,Masaki Noda
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Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors

Sheila Dias,Hamilton Silva, Jr.,Ana Cumano,Paulo Vieira
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In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

Leonie S. van Rijt,Steffen Jung,Alex KleinJan,Nanda Vos,Monique Willart,Catherine Duez,Henk C. Hoogsteden,Bart N. Lambrecht
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Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1

Dominique Gatto,Thomas Pfister,Andrea Jegerlehner,Stephen W. Martin,Manfred Kopf,Martin F. Bachmann
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Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence

Julianne Stack,Ismar R. Haga,Martina Schröder,Nathan W. Bartlett,Geraldine Maloney,Patrick C. Reading,Katherine A. Fitzgerald,Geoffrey L. Smith,Andrew G. Bowie
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Correction

Correction

Hyun-Joo Nam,Florence Poy,Haruo Saito,Christin A. Frederick
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