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5 September 2000
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Cover Image
Cover Image
Cover picture: A tumor necrosis factor (TNF)-sensitive cell line, L929 (top left: untreated control), exhibits an increase in intracellular ceramide that correlates with an atypical apoptosis (morphologic hallmarks of apoptosis despite a lack of caspase activity) in response to TNF (top right). When these cells overexpress acid ceramidase, the apoptotic features are strongly reduced (bottom right; bottom left shows the same cells without TNF). Thus, the inhibition of ceramide production by acid ceramidase increases survival of TNF-treated L929 cells, indicating that intracellular ceramide may be a major inducer of TNF-dependent cell death. See related article in this issue by Strelow et al, pp. 601-611. - PDF Icon PDF LinkTable of Contents
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ISSN 0022-1007
EISSN 1540-9538
In this Issue
Article
B Cells of HIV-1–Infected Patients Bind Virions through Cd21–Complement Interactions and Transmit Infectious Virus to Activated T Cells
Susan Moir,Angela Malaspina,Yuexia Li,Tae-Wook Chun,Tomeka Lowe,Joseph Adelsberger,Michael Baseler,Linda A. Ehler,Shuying Liu,Richard T. Davey, Jr.,Jo Ann M. Mican,Anthony S. Fauci
Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor: Formation of a Functional Heteromeric Complex Requires Interleukin 7 Receptor
Linda S. Park,Unja Martin,Kirsten Garka,Brian Gliniak,James P. Di Santo,Werner Muller,David A. Largaespada,Neal G. Copeland,Nancy A. Jenkins,Andrew G. Farr,Steven F. Ziegler,Philip J. Morrissey,Raymond Paxton,John E. Sims
Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor
John E. Sims,Douglas E. Williams,Philip J. Morrissey,Kirsten Garka,Diane Foxworthe,Virginia Price,Sherree L. Friend,Andrew Farr,Mary A. Bedell,Nancy A. Jenkins,Neal G. Copeland,Kenneth Grabstein,Raymond J. Paxton
Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells
Judith R. Abrams,Susan L. Kelley,Elizabeth Hayes,Toyoko Kikuchi,Michael J. Brown,Sewon Kang,Mark G. Lebwohl,Cynthia A. Guzzo,Brian V. Jegasothy,Peter S. Linsley,James G. Krueger
Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors
Marie-Caroline Dieu-Nosjean,Catherine Massacrier,Bernhard Homey,Béatrice Vanbervliet,Jean-Jacques Pin,Alain Vicari,Serge Lebecque,Colette Dezutter-Dambuyant,Daniel Schmitt,Albert Zlotnik,Christophe Caux
Brief Definitive Report
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment: Epithelial Expression of Tissue-Specific Chemokines as an Organizing Principle in Regional Immunity
Eric J. Kunkel,James J. Campbell,Guttorm Haraldsen,Junliang Pan,Judie Boisvert,Arthur I. Roberts,Ellen C. Ebert,Mark A. Vierra,Stuart B. Goodman,Mark C. Genovese,Andy J. Wardlaw,Harry B. Greenberg,Christina M. Parker,Eugene C. Butcher,David P. Andrew,William W. Agace
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