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Volume 191, Issue 2

17 January 2000

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Cover Image

Cover Image

Cover picture: B and T lineagederived Hodgkin and Reed-Sternberg cells from two cases of classical Hodgkin¹s disease were stained for expression of cytotoxic T cell markers using the immunoperoxidase (brown cells, B lineage) and the alkaline phosphatase (red cells, T lineage) methods. Original magnifications: x120. See related article in this issue by Müschen et al., .
Table of Contents
Editorial Board

ISSN 0022-1007

EISSN 1540-9538

In this Issue

Commentary
Article
Brief Definitive Report
Correction

Commentary

Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

Peter Lane

The Molecular and Cellular Origins of Hodgkin's Disease

Louis M. Staudt

Article

A Single Amino Acid Determines the Immunostimulatory Activity of Interleukin 10

Yaozhong Ding,Lihui Qin,Serguei V. Kotenko,Sidney Pestka,Jonathan S. Bromberg

Neonatal Tumor Necrosis Factor α Promotes Diabetes in Nonobese Diabetic Mice by Cd154-Independent Antigen Presentation to Cd8⁺ T Cells

E. Allison Green,F. Susan Wong,Koji Eshima,Conchi Mora,Richard A. Flavell

Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef: Generation of Multiple Definitive Major Histocompatibility Complex Class I Ligands by Proteasomes

Maria Lucchiari-Hartz,Peter M. van Endert,Grégoire Lauvau,Reinhard Maier,Andreas Meyerhans,Derek Mann,Klaus Eichmann,Gabriele Niedermann

The Role of Apoptosis in the Regulation of Hematopoietic Stem Cells: Overexpression of BCL-2 Increases Both Their Number and Repopulation Potential

Jos Domen,Samuel H. Cheshier,Irving L. Weissman

Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo

Clare M. Lloyd,Tracy Delaney,Trang Nguyen,Jane Tian,Carlos Martinez-A,Anthony J. Coyle,Jose-Carlos Gutierrez-Ramos

Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

Kanichiro Kobayashi,Naoyuki Takahashi,Eijiro Jimi,Nobuyuki Udagawa,Masamichi Takami,Shigeru Kotake,Nobuaki Nakagawa,Masahiko Kinosaki,Kyoji Yamaguchi,Nobuyuki Shima,Hisataka Yasuda,Tomonori Morinaga,Kanji Higashio,T. John Martin,Tatsuo Suda

Inhibition of Ca²⁺ Signaling by Mycobacterium tuberculosisIs Associated with Reduced Phagosome–Lysosome Fusion and Increased Survival within Human Macrophages

Zulfiqar A. Malik,Gerene M. Denning,David J. Kusner

Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene

Martin J.H. Nicklin,David E. Hughes,Jenny L. Barton,Jan M. Ure,Gordon W. Duff

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

Reiko Horai,Shinobu Saijo,Hidetoshi Tanioka,Susumu Nakae,Katsuko Sudo,Akihiko Okahara,Toshimi Ikuse,Masahide Asano,Yoichiro Iwakura

Activation of the p38 Mitogen-Activated Protein Kinase Pathway Arrests Cell Cycle Progression and Differentiation of Immature Thymocytes in Vivo

Nicole L. Diehl,Hervé Enslen,Karen A. Fortner,Chris Merritt,Nate Stetson,Colette Charland,Richard A. Flavell,Roger J. Davis,Mercedes Rincón

Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

Mark A. Daniels,Stephen C. Jameson

A Balance between Positive and Negative Signals in Cytotoxic Lymphocytes Regulates the Polarization of Lipid Rafts during the Development of Cell-Mediated Killing

Zhenkun Lou,Dragan Jevremovic,Daniel D. Billadeau,Paul J. Leibson

Tetracycline-controllable Selection of CD4⁺ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

Deborah Witherden,Nicolai van Oers,Caroline Waltzinger,Arthur Weiss,Christophe Benoist,Diane Mathis

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

Kazuko Murata,Naoto Ishii,Hiroshi Takano,Shigeto Miura,Lishomwa C. Ndhlovu,Masato Nose,Tetsuo Noda,Kazuo Sugamura

Brief Definitive Report

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

Hisaya Akiba,Yasushi Miyahira,Machiko Atsuta,Kazuyoshi Takeda,Chiyoko Nohara,Toshiro Futagawa,Hironori Matsuda,Takashi Aoki,Hideo Yagita,Ko Okumura

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

Norman Garceau,Yoko Kosaka,Sally Masters,John Hambor,Reiko Shinkura,Tasuku Honjo,Randolph J. Noelle

Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma

Markus Müschen,Klaus Rajewsky,Andreas Bräuninger,Audrey Sylvia Baur,Joost J. Oudejans,Axel Roers,Martin-Leo Hansmann,Ralf Küppers

Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's Lymphoma

Berit Jungnickel,Andrea Staratschek-Jox,Andreas Bräuninger,Tilmann Spieker,Jürgen Wolf,Volker Diehl,Martin-Leo Hansmann,Klaus Rajewsky,Ralf Küppers

In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4⁺ T Cell Independent

Qian Huang,Joan F.L. Richmond,Kimiko Suzue,Herman N. Eisen,Richard A. Young

Correction

Correction

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