Dendritic cells (DCs) phagocytose apoptotic cells and cross-present antigens derived from the dying cells to CD8+ T cells. Phagocytosis is restricted to the immature stage of DCs and is accompanied by the expression of the αvβ5 integrin and CD36. These receptors are downmodulated upon maturation. Although macrophages (Mφ) efficiently phagocytose apoptotic cells via many receptors, including αvβ3 and CD36, they do not cross-present antigens to CD8+ T cells. See related article in this issue by Albert et al., pp. 1359–1368.
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Type I Interferon Induces Inhibitory 16-kD CCAAT/ Enhancer Binding Protein (C/EBP)β, Repressing the HIV-1 Long Terminal Repeat in Macrophages: Pulmonary Tuberculosis Alters C/EBP Expression, Enhancing HIV-1 Replication
Involvement of Guanosine Triphosphatases and Phospholipase C-γ2 in Extracellular Signal–regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor
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