Issues

Section of a lung from a mouse given a protein extract of Aspergillus fumigatus intranasally three times per week is shown, with a dense inflammatory infiltrate in the connective tissue between a small vessel (right) and a bronchiole (left). The infiltrate consists predominantly of eosinophils with a smaller population of lymphocytes and macrophages. In the upper right corner, an alveolar airspace is present that contains several eosinophils, lymphocytes, and macrophages. The authors demonstrate that the seven transmembrane–spanning, G protein–coupled receptor for leukotriene B₄ (LTB₄) is upregulated in the lung after Aspergillus challenge. Hematoxylin and eosin staining was performed by Dr. Matt van de Rijn. See related article in this issue by Huang et al., 1063–1074.