Section of a lung from a mouse given a protein extract of Aspergillus fumigatus intranasally three times per week is shown, with a dense inflammatory infiltrate in the connective tissue between a small vessel (right) and a bronchiole (left). The infiltrate consists predominantly of eosinophils with a smaller population of lymphocytes and macrophages. In the upper right corner, an alveolar airspace is present that contains several eosinophils, lymphocytes, and macrophages. The authors demonstrate that the seven transmembrane–spanning, G protein–coupled receptor for leukotriene B4 (LTB4) is upregulated in the lung after Aspergillus challenge. Hematoxylin and eosin staining was performed by Dr. Matt van de Rijn. See related article in this issue by Huang et al., 1063–1074.
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Translation of a Retained Intron in Tyrosinase-related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage
The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope
Mast Cells Can Secrete Vascular Permeability Factor/ Vascular Endothelial Cell Growth Factor and Exhibit Enhanced Release after Immunoglobulin E–dependent Upregulation of Fcε Receptor I Expression
The Envelope Glycoprotein Ectodomains Determine the Efficiency of CD4+ T Lymphocyte Depletion in Simian– Human Immunodeficiency Virus–Infected Macaques
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