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    CD8+ cytotoxic T cells are essential to the mediation of glomerular injury in Heymann nephritis, a model of human membranous nephropathy. The photograph shows IgG deposition in the glomerular basement membrane of an isolated glomerulus from a rat with active Heymann nephritis. CD8+ T cell depletion prevented proteinuria and glomerular infiltration by activated T cells and macrophages, although there was the characteristic glomerular deposition of IgG and C3. Glomeruli were isolated by graded sieving, enzymatically permeabilized, and stained by indirect immunoperoxidase with anti–rat IgG κ antibody (MRC-OX12). See related article in this issue by Penny et al., pp. 1775–1784.

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ISSN 0022-1007
EISSN 1540-9538
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