Issues

CD8⁺ cytotoxic T cells are essential to the mediation of glomerular injury in Heymann nephritis, a model of human membranous nephropathy. The photograph shows IgG deposition in the glomerular basement membrane of an isolated glomerulus from a rat with active Heymann nephritis. CD8⁺ T cell depletion prevented proteinuria and glomerular infiltration by activated T cells and macrophages, although there was the characteristic glomerular deposition of IgG and C3. Glomeruli were isolated by graded sieving, enzymatically permeabilized, and stained by indirect immunoperoxidase with anti–rat IgG κ antibody (MRC-OX12). See related article in this issue by Penny et al., pp. 1775–1784.