An Fcγ receptor–transfected COS cell mediates phagocytosis of IgG-opsonized RBCs into phagosomes. COS cells transfected with Fcγ receptors were incubated with FITC-labeled RBCs opsonized with IgG to examine phagocytosis. In this photomicrograph the orange cytoplasm (ethidium bromide) of the COS cell contrasts with the green fluorescence of the FITC-labeled RBCs found inside vesicles. The COS cell system was further used to examine in detail the steps of the phagocytic process mediated by Fcγ receptors. See related article in this issue by Lowry et al., pp. 161–176.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture
Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6) Stimulates Extracellular Signal–regulated Kinase (ERK) Activity in CD40 Signaling Along a Ras-independent Pathway
Brief Definitive Report
Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes