Histologic section of dorsal skin from a representative C57BL/6 mouse. Sections were stained with a rabbit polyclonal histamine antibody and mast cells were visualized with a peroxidase-labeled sheep anti–rabbit second antibody (brown). Sections were counterstained with hematoxylin solution (blue). The prevalence of dermal mast cells in the skin of different mouse strains correlates with their susceptibility to systemic immunomodulation by UVB radiation. In addition, mast cell–deficient mice are resistant to immunomodulation, whereas dermal reconstitution with mast cells restores susceptibility. See related article in this issue by Hart et al., pp. 2045–2053.
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Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3
NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis
Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production
Brief Definitive Report