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Cell Biology of Infection and the Immune Response 2018

Microbial pathogens have evolved diverse strategies to ensure their survival and replication, while host cells have complex mechanisms to detect infection and neutralize invaders. Understanding how cells mount an effective and measured immune response and the complex interactions between host and pathogens - for viruses, bacteria, and other microbes to evade the host's immune response and for the host to detect, target, and eliminate the infection - is essential to understand the basis of various human diseases and develop appropriate treatments.

In this special collection, JCB Board member Craig Roy and Senior Scientific Editor Melina Casadio explore recent exciting JCB articles that delve into the cell biology and immunobiology of host/pathogen interactions. These papers include some of our most downloaded articles about the mechanisms of pathogen invasion and replication, innate immune signaling, and the determinants of the adaptive immune response. We hope you'll enjoy this collection and look forward to your feedback on social media. Image courtesy of Leptin et al. See: Dynamics of in vivo ASC speck formation.


virus, Immunology, pathogen, immune response, bacteria, cancer, infection, microbiology, inflammation

Special Collection Image
Eduardo P. Amaral; Diego L. Costa; Sivaranjani Namasivayam; Nicolas Riteau; Olena Kamenyeva; Lara Mittereder; Katrin D. Mayer-Barber; Bruno B. Andrade; Alan Sher
DOI: 10.1084/jem.20181776
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