Lysine-ϵ-C14-labeled plasma proteins produced by the normal rat and the isolated perfused rat liver have been fractionated by preparative zone electrophoresis. The isolated perfused liver incorporates lysine-ϵ-C14 into the plasma albumin, alpha globulin, and beta globulin (including fibrinogen) fractions. No significant C14 incorporation into the trichloracetic acid-precipitable proteins of the gamma globulin fraction was observed.

Presumptive evidence indicates that the alpha globulins turn over more rapidly than any other major plasma protein fraction.

The increased production of gamma globulins in liver disease is discussed.

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