The extracellular survival and development in vitro of the erythrocytic stages of Plasmodium lophurae were favored by the addition to the culture medium of l-malic acid and concentrates rich in coenzyme A. In a concentrated extract of duck erythrocytes supplemented with these two substances in addition to adenosinetriphosphate, sodium pyruvate, and certain other materials of like nature, only 5 to 10 per cent of the extracellular parasites had become abnormal after 3 days of cultivation.
STUDIES ON THE EXTRACELLULAR CULTIVATION OF AN INTRACELLULAR PARASITE (AVIAN MALARIA) : II. THE EFFECTS OF MALATE AND OF COENZYME A CONCENTRATES
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William Trager; STUDIES ON THE EXTRACELLULAR CULTIVATION OF AN INTRACELLULAR PARASITE (AVIAN MALARIA) : II. THE EFFECTS OF MALATE AND OF COENZYME A CONCENTRATES . J Exp Med 1 November 1952; 96 (5): 465–476. doi: https://doi.org/10.1084/jem.96.5.465
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