CF tests with Type 2 poliomyelitis antigen (MEF1) were performed on the pre- and postinfection sera of 20 cynomolgus monkeys which developed paralytic, non-paralytic, or inapparent infection following oral administration of a Type 2 strain of virus (Y-SK). All the monkeys developed neutralizing antibody, and 17 developed CF antibody in an original serum dilution titer of 1:4 or greater. The 3 monkeys which did not develop this level of CF antibody were in a group of 7 which died within 8 days after onset of paralysis. The CF titers were as high at 2 to 6 days after onset of paralysis in the other 4 moribund or dead monkeys as in the surviving animals tested 4 weeks after the first dose of virus and the CF titers were of the same order of magnitude in the groups with paralytic, non-paralytic, or inapparent infection. The Type 2 poliomyelitis CF titers developed in monkeys as a result of infection with homotypic virus were not greater than those found in human beings infected with heterotypic Type 1 poliomyelitis strains.
HOMOTYPIC COMPLEMENT-FIXING ANTIBODY IN MONKEYS INFECTED WITH TYPE 2 POLIOMYELITIS VIRUS BY THE ORAL ROUTE
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Jordi Casals, Peter K. Olitsky, Albert B. Sabin; HOMOTYPIC COMPLEMENT-FIXING ANTIBODY IN MONKEYS INFECTED WITH TYPE 2 POLIOMYELITIS VIRUS BY THE ORAL ROUTE . J Exp Med 1 July 1952; 96 (1): 55–58. doi: https://doi.org/10.1084/jem.96.1.55
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