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Volume 88, Issue 4
1 October 1948
Journal of Experimental Medicine Cover Image for Volume 88, Issue 4
Article| October 01 1948

STUDIES ON ACUTE DISSEMINATED ENCEPHALOMYELITIS PRODUCED EXPERIMENTALLY IN RHESUS MONKEYS. III

Elvin A. Kabat,
Elvin A. Kabat
From the Departments of Neurology, Bacteriology, and Pathology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, New York
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Abner Wolf,
Abner Wolf
From the Departments of Neurology, Bacteriology, and Pathology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, New York
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Ada E. Bezer
Ada E. Bezer
From the Departments of Neurology, Bacteriology, and Pathology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, New York
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Author and Article Information
Elvin A. Kabat
From the Departments of Neurology, Bacteriology, and Pathology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, New York
Abner Wolf
From the Departments of Neurology, Bacteriology, and Pathology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, New York
Ada E. Bezer
From the Departments of Neurology, Bacteriology, and Pathology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, New York
Received: July 06 1948
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1948, by The Rockefeller Institute for Medical Research New York
1948
J Exp Med (1948) 88 (4): 417–426.
https://doi.org/10.1084/jem.88.4.417
Article history
Received:
July 06 1948

The factor in brain tissue which induces acute disseminated encephalomyelitis, when injected into rhesus monkeys as an emulsion with adjuvants, has been found in human, monkey, rabbit, and chicken brain but is absent from frog and fish brain. It is unaffected by fixation of the brain in formalin, by boiling, and by treatment with ultrasound. It is present in the spinal cord of 3 day old rabbits but does not appear in the rabbit cerebrum until about the 12th day of life; in this respect it parallels the laying down of myelin. Attempts to produce the encephalomyelitis passively with large quantities of serum or of cell exudates, and suspensions of cells from spleen and lymph node from monkeys with encephalomyelitis, were unsuccessful.

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Copyright, 1948, by The Rockefeller Institute for Medical Research New York
1948
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