1. Dehydration, if sufficiently prolonged, favors the accumulation of hemoglobin or its derivatives in the kidneys of rabbits, principally casts formed in the distal convoluted tubules.
2. Once pigment casts have been produced in the distal convoluted tubules, there is obstruction, with atrophy and dilatation of the tubules proximal to the obstruction.
3. When the involvement is sufficiently extensive, there is elevation of the non-protein nitrogen and some animals die because of renal failure.