MOUSE-PROTECTIVE TITERS OF SERA OF VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES

Walter , Annabel W.; Schenkein , Edna L.; Sutliff , Wheelan D.

doi:10.1084/jem.83.4.321

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Article| April 01 1946

MOUSE-PROTECTIVE TITERS OF SERA OF VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES

Annabel W. Walter,

Annabel W. Walter

From the Bureau of Laboratories of the Department of Health of the City of New York, New York

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Edna L. Schenkein,

Edna L. Schenkein

From the Bureau of Laboratories of the Department of Health of the City of New York, New York

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Wheelan D. Sutliff

From the Bureau of Laboratories of the Department of Health of the City of New York, New York

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Author and Article Information

Annabel W. Walter

From the Bureau of Laboratories of the Department of Health of the City of New York, New York

Edna L. Schenkein

From the Bureau of Laboratories of the Department of Health of the City of New York, New York

Wheelan D. Sutliff

From the Bureau of Laboratories of the Department of Health of the City of New York, New York

Received: December 12 1945

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1946, by The Rockefeller Institute for Medical Research New York

1946

J Exp Med (1946) 83 (4): 321–328.

https://doi.org/10.1084/jem.83.4.321

1. Sera of human subjects immunized with pneumococci or their type-specific polysaccharides showed type-specific antibody by mouse protection tests as well as on determinations of the specifically precipitable nitrogen.

2. The ratio, mouse-protective units to antibody nitrogen, was less in human sera of low potency than in more potent human or animal sera.

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Copyright, 1946, by The Rockefeller Institute for Medical Research New York

1946

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MOUSE-PROTECTIVE TITERS OF SERA OF VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES

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