1. The administration of tartrate to adult rabbits was found to produce in some of them, a profound and widespread necrosis of the proximal convoluted tubular epithelium without affecting the other portions of the nephrons.

2. The markedly damaged kidneys were found to be almost completely devoid of pressor substance (renin), indicating that in the mammalian kidney, the epithelium of the proximal convoluted tubules is concerned in the formation or storage of renin.

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